Nephrotic
syndrome is a condition that is often caused by any of a group of diseases
that damage the kidneys’ filtering system, the glomeruli. The structure of
the glomeruli prevents most protein from getting filtered through into the
urine. Normally, a person loses less than 150 mg of protein in the urine
in a 24-hour period. The loss of more than 3 grams of protein during a
24-hour period leads to the diagnosis of nephrotic syndrome.
The nephrotic syndrome is not itself a disease. But
it can be the first sign of a disease that damages the kidney's tiny
blood-filtering units, called glomeruli, where urine is made.
Natural Treatment for Nephrotic Syndrome
At this time I am not aware of any specific natural treatment for
nephrotic syndrome except for the two herbs listed below:
Nephrotic Syndrome treatment with natural supplements
Antifibrotic effect of the Chinese herbs,
Astragalus mongholicus and
Angelica sinensis (
Dong Quai ), in a rat model of chronic puromycin aminonucleoside
nephrosis.
Life Sci. 2004 Feb 13;74(13):1645-58.
Nephrotic syndrome has long been treated in China with two herbs,
Astragalus mongholicus and Angelica sinensis, which may have antifibrotic
effects. Rats with chronic puromycin-induced nephrosis were
treated with Astragalus and Angelica 3 mL/d (n = 7) or enalapril 10
mg/kg/d (n = 7). Normal control rats (n = 7) received saline rather than
puromycin, and an untreated control group (n = 7) received puromycin but
no treatment. After 12 weeks, stained sections of the glomerulus and
tubulointerstitium were evaluated for injury. Immunohistochemistry
staining measured extracellular matrix components, transforming growth
factor-beta1 (TGFbeta1), osteopontin, ED-1-positive cells, and alpha-actin.
TGFbeta1 mRNA was assessed by in situ hybridization. Renin, ACE activity,
angiotensin, and aldosterone were measured by radioimmunoassay or
colorimetry. In the untreated rats, chronic renal injury progressed to
marked fibrosis at 12 weeks. Astragalus and Angelica significantly reduced
deterioration of renal function and histologic damage. Expressions of type
III and IV collagen, fibronectin, and laminin also decreased
significantly. This anti-fibrotic effect was similar to that of enalapril.
The herbs had no effect on the renin-angiotensin system but did reduce the
number of ED-1-positive, and alpha-actin positive cells and expression of
osteopontin compared to untreated controls. The combination of Astragalus
and Angelica retarded the progression of renal fibrosis and deterioration
of renal function with comparable effects of enalapril. These effects were
not caused by blocking the intrarenal renin-angiotensin system, but
associated with suppression of the overexpression of TGFbeta1 and
osteopontin, reduction of infiltrating macrophages, and less activation of
renal intrinsic cells [corrected].
Nephrotic Syndrome in Child
Nephrotic syndrome in a child can occur at any age but is more
common between the ages of 1 and 6 years. A child with the nephrotic
syndrome has high levels of protein in the urine, swelling resulting from
buildup of salt and water, and low levels of protein in the blood.
Nephrotic Syndrome Treatment
Nephrotic syndrome can now be treated with a low-salt diet,
diuretics to reduce edema, and statins to normalize serum lipid
concentrations. Natural supplements are an interesting, but untested
approach to reduce
cholesterol and lipid problems in patients with nephrotic syndrome.
Patients with nephrotic syndrome are prone to deep vein thrombophlebitis,
renal vein thrombosis, and pulmonary emboli. Depending on the condition,
additional treatment may include corticosteroids, angiotensin-converting
enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs),
cyclosporine, cytotoxic agents, or mycophenolate.
Symptom of Nephrotic Syndrome
In addition to proteinuria, there are three main symptoms of
nephrotic syndrome associated with protein leaking into the urine:
Hypoalbuminemia (low level of albumin in the blood); Edema (swelling); and
Hypercholesterolemia (high level of cholesterol in the blood).
Nephrotic Syndrome questions
Q. Do you think lipoic
acid is helpful for nephrotic syndrome?
A. I have not seen such research.