What conditions is it helpful
Nexium is used to treat ulcers, gastroesophageal reflux disease (GERD or heartburn), erosive esophagitis, and other conditions involving excessive stomach acid production.
Who should not take it?
Before taking Nexium, tell your doctor if you have ever had any type of liver disease. You may not be able to take Nexium, or you may require a dosage adjustment or special monitoring.
Nexium, pregnancy and
Nexium is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby, however sometimes information comes our years later that a particular drug is more harmful than initially thought. Doctors are not sure whether Nexium passes into breast milk. Do not take Nexium without first talking to your doctor if you are breast-feeding a baby.
How to take this medication
It is recommended to take each Nexium dosage with a full glass of water. It should be taken at least one hour before a meal. Do not break or chew the Nexium capsules since they are formulated to release slowly in the body. There are no restrictions on food, beverages, or activities while taking Nexium.
Recommended adult Nexium dosage for treatment of esophagitis is 20 mg or 40 mg one capsule daily 4 to 8 weeks (unless otherwise directed by your doctor).
What happens if a person misses a Nexium dosage?
This is not a crucial problem, just skip the missed Nexium dosage and take only your next regularly scheduled dosage. Do not take twice as much.
What are the symptoms of Nexium overdose?
Symptoms of an Nexium overdose include drowsiness, shortness of breath, tremor and loss of coordination.
Side effects of Nexium, danger, safety, risk
Nexium began to be used in 2001. It takes many years to find out the full range of side effects of Nexium or other drugs. Serious adverse reactions could be an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives). Other Nexium side effects reported include headache, diarrhea, nausea, flatulence, abdominal pain, or constipation; or dry mouth. Some studies indicate headache is common. The most common Nexium side effects appear to be gastrointestinal. This medication can interfere with the absorption of certain drugs. By preventing high acidity in the stomach, it is theoretically possible that chronic use of this drug may lead to a higher rate of gastrointestinal infections since not enough acid is available to kill germs in the stomach.
Curr Drug Saf. 2011. Hypomagnesaemia / hypokalemia associated with the use of esomeprazole. Low magnesium and potassium levels in the blood.
Taking a heartburn medication such as AstraZeneca's Nexium increases the risk of diarrhea blamed on the Clostridium difficile bacteria. Nexium reduces gastric acid, allowing for bacteria to multiply in the digestive system. Clostridium is the third-most common type of infectious diarrhea in patients aged 75 and older. Exposure to Clostridium difficile bacteria, which causes infection and inflammation of the intestine, previously occurred mostly during hospital stays, but cases have increasingly been contracted in community settings. While antibiotics formerly blamed for outbreaks of the illness have declined in use, the acid-blocking drugs have become steadily more popular to treat ulcers and conditions such as gastric reflux disease.
Nexium and bone fracture
PPIs may be associated with bone fracture. Prolonged use of proton pump inhibitors such as Nexium, particularly at high doses, is linked to increased risk of hip fracture in the elderly.
questions from users
I took Nexium everyday for over 9 months. Now i have severe symptoms of IBS. I have major gas, rumbling in the stomach, diarrhea and burping a warm sulfur like taste. I'm assuming the Nexium killed all the healthy bacteria, so I'm getting some probiotics from CVS to take to restore the healthy bacteria.
Ten months ago
I was hospitalized for a bleeding ulcer. Following a heart attack five years ago
I was prescribed a daily regimen of 81mg of aspirin which was the cause of the
ulcer. I was advised to take 40 mg of of Nexium daily for as long as I was
taking aspirin. I have osteoporosis and I understand that Calcium Citrate does
not need acid to make it bioavailable. I hope that this is correct. In addition
to this what are the long term dangers of continuing to take Nexium and are the
risks from long term nexium usage reduced if I switched to 20mg daily.
Reducing the dosage is likely to reduce the long term risks.
I have been taking
40 mg per day four years ago. About two years ago I have been having balance
problems when walking and some kind of fatigue in my lower legs. Can this be a
side effect of Nexium ?
It is possible but there are other reasons for balance problems and especially fatigue. A reliable way to know is to stop the medication to see if the symptoms go away and to restart it to see if the symptoms return.
I have been taking nexium 40 mg for 12 years. I open the capsule and swallow the granules since I cannot swallow pills or capsules. I chew tablets and open capsules. Two months ago I suddenly developed painful edema in my feet, ankles, and lower legs. All radiological and blood tests have been negative.
Nexium and drug interactions
It is possible that Nexium may interfere with digoxin (Lanoxin, Lanoxicaps); itraconazole (Sporanox) or ketoconazole (Nizoral); or iron (Feosol, Mol-Iron, Fergon, Femiron, others).
Can I stop using Nexium if I feel
Since most drugs have side effects in the long run, if your symptoms were not serious and you feel better, it may be a good idea to stop it if your doctor thinks your condition is fully treated. Sometimes doctors put patients on medicines and do not reevaluate often enough whether the patient still needs the medicines.
How is Nexium available?
Nexium is available is 20 mg and Nexium 40 mg dosage, delayed release. Nexium (esomeprazole magnesium, AstraZeneca) delayed-release capsules were approved in 2006 for use in children ages 12 to 17 for the short-term treatment of gastroesophageal reflux disease (GERD).
Nexium for children
In 2008, Nexium drug was approved by the FDA for treating excess stomach acid in children aged 1 to 11 years.
The FDA approved Nexium, Astra's top seller and the world's second-biggest prescription medicine, in two forms -- a delayed response capsule and a liquid. Nexium was approved in a dose of 10 milligrams, or 20 milligrams daily, for children aged between 1 and 11 -- half the dosage for patients aged 12 to 17.
Comments: Long term safety of Nexium in children is not clearly understood.
Nexium ads on TV claim that it relieves heartburn and esophagitis. The ads mention that headache, diarrhea, and abdominal pain are Nexium side effects. The phone number is listed as 800-purplepill. The website is purple pill dot com.
Q. Are there natural alternatives to Nexium?
A. I am not aware of a natural source of a proton pump inhibitor, but there are some supplements used for ulcer that are worth a try.
Q. My fiance was diagnosed with Barretts Esophagus in 2006. Since then his specialist has prescribed him with 80mg of Nexium a day. Recently my fiance has been feeling very ill with Nexium side effects. Major headaches, diarrhea, nausea, dizziness and tightness in his throat, making it difficult to swallow. Then we went to visit the specialist last week for an Upper GI to see what the problem was. Thankfully his Barretts is gone, but the doctor said to keep taking the same dosage of Nexium. My fiance still could not function normally, so he on his own stopped taking the Nexium and started to eat foods with low levels of acid and started to feel much better. His father died of cancer in the esophagus.
Thanks for sharing this Nexium side effect experience with us. We are surprised
about Barrett's esophagus syndrome being gone, we wonder if the initial
diagnosis was correct.
Q. What was it
you said about the unwanted side effects of Nexium? That it take years to know
what all of these side effects will be? Well, now were paying the bill for that
asinine method of determining the safety of a drug. I'm referring to the article
in The New York Times, December 27, 2006 "Study Finds a Link Between Some
Heartburn Drugs and Hip Injuries in People Over 50". You Medicos should know
that about the human system. You can't take from one part of the human system
without paying back to another. Were you getting paid from Astra Zenica pharma
that makes Nexium for touting the benefits?
A. Many times in my life I have made a quick judgment about someone without first understanding them in a fuller way. You may wish to spend more time on my website reading a number of different pages and you will realize your last statement in your email was quite off the mark.
Q. I believe I
suffered an overdose of Nexium medication. I have been diagnosed with oscillopsia, ataxia,
severe difficulty swallowing, I have a swollen membrane in the inner ear,
frequent headaches and my blood platelet count is now 88.
My doctor has said this was all caused by a virus of unknown origin, yet, when
my blood was tested, I showed no signs of a virus or a bacterial infection. He
then diagnosed opsoclonus myoclonus ataxia, had me COMPLETELY tested for that,
and according to the tests, I'm fine. I have no brain issues (CT scan and MRI),
I have no genetic disorders, no cancers, I am a perfectly healthy 44 year old
woman other than the obvious issues. Is there any type of test or testing that
would prove Nexium is what has caused this? If so, do you know if there is any
way to fix me?
A. Sorry, this is outside of my range of knowledge.
Q. I am a neurologist and the individual above needs a full neurological work up, but certainly should be checked for Whipple's disease and remote effect of neural crest tumors. I hope you can pass on this information to her so she can see a competent neurologist.
Q. I read your
page regarding Nexium usage, but something I haven't been able to find
information on is long term Nexium use. I've been taking Nexium everyday for the
past 3 years, since I was diagnosed with a hiatal hernia. If I go off it for a
week, my stomach hurts, I have diarrhea, and can eat hardly anything, but I am
afraid to keep taking the drug indefinitely. My father died of stomach and
esophageal cancer, so the whole issue scares me. Do you have any information
regarding my concern about long term safety or side effects of Nexium medication
A. Not enough long term human research with Nexium is available to know the full extent of Nexium side effects. Until we learn more, the best option is to take occasional breaks as tolerated and to use the lowest dosage that works. Taking occasional breaks may reduce potential long term Nexium side effects.
Q. Is it true
that long term use of Nexium can cause pernicious anemia due to malabsorption of
A. Yes, it is possible that Nexium drug use can lead to reduced absorption of protein bound vitamin B12 but taking vitamin B12 supplements should not be a problem.
Q. I have been
taking Nexium drug for 8 years or more. I really can't recall how long. I had
either irritable bowel syndrome or acid reflux my throat hurt and this seemed to
do the trick. I take 40 mg per day every day. Now I can drink orange juice and
coffee and hot sauce with no effects. None of these were possible before. I do
have an occasional migraine maybe 3 times a year not more and they could be
stress. I am a 49 year old male and have never broken a bone although very
active all my life. I only drink about 24 oz of milk a day due to being recently
diabetic. Am I in danger of osteoporosis at this age? Do I need to limit my use
although my doctor has never indicated to do so? How can I help the medical
profession understand long term use of this drug?
A. Osteoporosis usually occurs later in life and is more likely in women than in men. Sometime in the next few years your doctor may order a bone density test if he or she feels you need it due to being on Nexium medication for many years. Research regarding Nexium and osteoporosis is still in its early stages.
I stumbled upon
the website when I was looking at Nexium alternatives and was wondering if you
have any info on H. Pylori, gastritis treatment with supplements and herbs, and
diet? I didn't see it on your website but if you could refer me to a trusted
source, I would appreciate it. To add to the info on Nexium use and side effects
that you have: I had terrible side effects, besides diahrrea at 40 mg a day
which where prescribed to treat astrophic gastritis, even when reduced to 20 mg
had a very suppressed, flat mood: very disabling, hard to function. My GI said
it is not common but occurs in small percentage of patients. I tried B
supplements and it works a little better but not well enough. When evaluating
the benefits of taking Nexium, I didn't feel it was benefiting me enough for me
to continue taking them especially that my symptoms are not as disabling as when
I take the drug. Thanks so much. great info on the web and if you get a chance
to forward me some info on H. Pylori, it would be much appreciated! Keep up the
good work, it is always refreshing to see MD who is not completely closed to the
See helicobacter pylori for information on natural therapy.
I was hoping to
ask a fast question. I have been eating medjool dates and date rolls for the
past two months almost daily. All of a sudden when I eat them I get massive
stomach cramps that won't go away unless I take copius amounts of acidophilus.
Could it be the magnesium held in these is starting to bother me or some other
property held within? They did not bother me at all the first 6 weeks of
consuming them. My Dr. put me on Nexium but I would think it doubtful that these
dates could have caused some kind of ulcer. I eat other food normally with no
problem. I hope you can help give an opinion.
It is not possible to know without doing a full history and medical examination and review of routine tests, but it is unlikely that the magnesium is causing problems. Dates are high in fructose.
I have been
taking Nexium for four months for GERD; it works wonderfully, but the side
effects, including depression and joint pain are too much to handle. Since going
off it, my acid reflux is better than before, but still bothers me sometime. Of
course my favorite foods are coffee, red wine, chocolate and garlic; that
probably doesn't help. I'm a sixty-seven year old man of normal weight and in
otherwise great health. Do you have any suggestions for herbal alternatives?
See the article on this site regarding GERD.
I have a
question about the prolonged use of Nexium. Here is the background on me: I’m a
56-year old female in good health. About a year ago I started having problems
swallowing. It wasn’t a classic example of GERD exactly; it was more that food
would not go down easily. I frequently found myself choking or coughing until
the food would go down. This of course lead to my seeing a GI who ordered an
esophagram followed by an endoscopy — both were done last November. The
endoscopy revealed Barret’s esophagus and also a superficial ulcer in my
stomach. I was put on Nexium, 40 mg and told to come back for a repeat endoscopy
in February, 2010 which I did. The second procedure revealed that the Barrett’s
esophagus / ulcer was fully healed as well as the stomach ulcer. My dosage was
reduced to 20 mg. I feel fine and have no repeats/issues with food not going
down, with digestion, or with any of the side effects mentioned (diarrhea,
tiredness, headache, etc.). In fact, I feel quite good! My doctor said to come
back in a year for another endoscopy and to re-evaluate my need for nexium.
Questions: I’d like to know if I should continue with the nexium, as proscribed,
or if it is possible to take it less frequently, or perhaps not at all? This is
the only medication I have ever taken on a regular basis my entire life. I have
no other chronic ailments or issues. My doctor says I will probably be taking
this medication for the rest of my life. Is this a fair assessment? For the
record, my father also suffers from heartburn and gastric reflux. He is 85. Is
this a condition I most likely inherited? I believe my grandmother, his mother,
also had ulcers and digestive issues. I’d appreciate your feedback.
This is not a decision I can make for you since I am not your physician but you could take a look at the pages on this site on Barrett's and ulcer.