Noxafil antifungal medication
August 17 2017 by
Ray Sahelian, M.D.

Noxafil (posaconazole) is used to prevent fungal infections caused by certain molds and yeast-like fungus called Aspergillus and Candida. Noxafil is used in patients who have weakened immune systems following bone marrow transplants and for patients with a condition (decreased white blood cell counts) that makes it difficult for the body to fight infections following chemotherapy for cancer.

Noxafil side effects, adverse reactions
The safety and efficacy of Noxafil were evaluated in clinical trials consisting of 1,844 patients between 13 and 82 years of age. In two, randomized, controlled studies of patients who had compromised immunity and were at high risk for invasive fungal infections, those patients who received Noxafil had comparable or lower rates of invasive Aspergillus and Candida infections than those patients who received other antifungal medications.
   The most common adverse reactions were nausea, vomiting, diarrhea, rash, a decrease in potassium blood levels and platelet counts, and abnormalities in liver function tests. Infrequent Noxafil side effects include QTc prolongation (abnormal heart rhythm) and liver function impairment.

Expert Opin Drug Safety. 2013. Safety of posaconazole. The increasing number of invasive fungal infections among immunocompromised hosts is a significant clinical issue. Diagnosis of IFI, choosing among the available antifungal drugs, and the high morbidity/mortality associated with IFI pose clinical challenges for healthcare providers. Besides efficacy, a thorough knowledge of the pharmacokinetics, drug-drug interactions and safety profile of the antifungal drugs is critical for appropriate drug selection. Among the commonly used triazoles, the recently released posaconazole is relatively less well investigated in terms of its safety. With expanding clinical use of posaconazole, the present review examines the safety of the drug and its propensity for drug-drug interaction. This paper mainly discusses the safety profile, its adverse effects and drug-drug interaction. Posaconazole is generally safe and well tolerated. Lack of an intravenous formulation and unpredictable bioavailability of the suspension form are significant factors limiting the widespread use of posaconazole.

Take Noxafil with a meal
Noxafil must be taken with a full meal to allow adequate absorption of the drug into the body so it can take effect. Noxafil has been shown to interact with several prescription medications, including drugs that suppress the immune system, and these reactions may be serious.

The triazole antifungal posaconazole was first approved as an oral suspension formulation. Despite pharmacokinetic target attainment and clinical efficacy in premarketing trials, postmarketing analyses indicated unpredictable bioavailability resulting in subtherapeutic concentrations and reports of breakthrough fungal infections.

Noxafil is manufactured by Schering-Plough Corporation, Kenilworth, NJ.