Noxafil antifungal medication
August 17 2017 by Ray Sahelian, M.D.
Noxafil (posaconazole) is used to prevent fungal infections caused by certain molds and yeast-like fungus called Aspergillus and Candida. Noxafil is used in patients who have weakened immune systems following bone marrow transplants and for patients with a condition (decreased white blood cell counts) that makes it difficult for the body to fight infections following chemotherapy for cancer.
Noxafil side effects, adverse reactions
The safety and efficacy of Noxafil were evaluated in clinical trials consisting of 1,844 patients between 13 and 82 years of age. In two, randomized, controlled studies of patients who had compromised immunity and were at high risk for invasive fungal infections, those patients who received Noxafil had comparable or lower rates of invasive Aspergillus and Candida infections than those patients who received other antifungal medications.
The most common adverse reactions were nausea, vomiting, diarrhea, rash, a decrease in potassium blood levels and platelet counts, and abnormalities in liver function tests. Infrequent Noxafil side effects include QTc prolongation (abnormal heart rhythm) and liver function impairment.
Expert Opin Drug Safety. 2013. Safety of posaconazole. The
increasing number of invasive fungal infections among immunocompromised
hosts is a significant clinical issue. Diagnosis of IFI, choosing among the
available antifungal drugs, and the high morbidity/mortality associated with IFI
pose clinical challenges for healthcare providers. Besides efficacy, a thorough
knowledge of the pharmacokinetics, drug-drug interactions and safety profile of
the antifungal drugs is critical for appropriate drug selection. Among the
commonly used triazoles, the recently released posaconazole is relatively less
well investigated in terms of its safety. With expanding clinical use of
posaconazole, the present review examines the safety of the drug and its
propensity for drug-drug interaction. This paper mainly discusses the safety
profile, its adverse effects and drug-drug interaction. Posaconazole is
generally safe and well tolerated. Lack of an intravenous formulation and
unpredictable bioavailability of the suspension form are significant factors
limiting the widespread use of posaconazole.
Take Noxafil with a meal
Noxafil must be taken with a full meal to allow adequate absorption of the drug into the body so it can take effect. Noxafil has been shown to interact with several prescription medications, including drugs that suppress the immune system, and these reactions may be serious.
The triazole antifungal posaconazole was first approved as
an oral suspension formulation. Despite pharmacokinetic target attainment and
clinical efficacy in premarketing trials, postmarketing analyses indicated
unpredictable bioavailability resulting in subtherapeutic concentrations and
reports of breakthrough fungal infections.
Noxafil is manufactured by Schering-Plough Corporation, Kenilworth, NJ.