Oroxylum Indicum herb
January 20 2016 by Ray Sahelian, M.D.

Indian Trumpetflower seed extract --  Mu Hu Die -- Common name -- Midnight Horror. This is an herb used in Chinese medicine.

Benefits
Lab studies show the seeds of oroxylum indicum to have anti-tumor potential.

Food Chem Toxicol. December 2013. Modulation of liver function, antioxidant responses, insulin resistance and glucose transport by Oroxylum indicum stem bark in STZ induced diabetic rats.

Chemical Composition
The seeds of oroxylum have a high content of flavonoids, including baicalein and chrysin.

Specifically oroxin B, chrysin, baicalein, neglectein, quercetin-3-O-β-D-galactopy ranoside, quercetin-7-O-β-D-glucopyranoside, 2α,3β-dihydroxylluPeol, lupeol, rengyol, β-sitosterol, and stigmasterol.

Historical Uses
Oroxylum indicum has been used for cough and wheeze

Research
Studies of the anti cancer potential of plants used in Bangladeshi folk medicine.
J Ethnopharmacology. 2005.
The present study evaluated the anticancer potential of 11 plants used in Bangladeshi folk medicine. The extracts were tested for cytotoxicity using the brine shrimp lethality assay, sea urchin eggs assay, hemolysis assay and MTT assay using tumor cell lines. The extract of Oroxylum indicum showed the highest toxicity on all tumor cell lines tested. The extract of Aegle marmelos exhibited toxicity on all used assays, but in a lower potency than Oroxylum indicum. In conclusion, among all tested extracts, only the extracts of Oroxylum indicum, Moringa oleifera and Aegles marmelos could be considered as potential sources of anticancer compounds. Further studies are necessary for chemical characterization of the active principles and more extensive biological evaluations.

Comparison of high-speed counter-current chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum.
J Chromatography A. 2005.
Analytical Milli high-speed counter-current chromatography (HSCCC) was used for the selection and optimization of the two-phase solvent system to separate flavonoids from the extracts of the seeds of Oroxylum indicum. Four flavonoids were isolated by preparative HSCCC: baicalein-7-O-diglucoside (25.0 mg, 92% purity), baicalein-7-o-glucoside (50.4 mg; 95% purity), baicalein (75 mg; purity 98%) and chrysin (100 mg; purity 98%).

Isolation and identification of four flavonoid constituents from the seeds of Oroxylum indicum by high-speed counter-current chromatography.
J Chromatogr A. 2003.
Four flavonoids, chrysin, baicalein, baicalein-7-O-glucoside, baicalein-7-O-diglucoside (Oroxylin B) and one unknown flavonoid have been isolated and purified for the first time in the seeds of Oroxylum indicum.

Q. Does 5-htp nutrient or coq10 cardiovascular pill interfere with this herb?
   A. I have not seen any such studies to know for sure.

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