Natural osteoarthritis treatment
The most commonly used alternative or
complementary nutrients for osteoarthritis are glucosamine and chondroitin. Several other
nutrients and herbs may potentially help reduce symptoms. Devil's claw, cat's
claw, ginger, nettle, rosehip, turmeric, willow bark, Indian frankincense and
vegetable extracts of avocado or soybean oils are all among the herbal medicines
traditionally used to treat osteoarthritis and additional research is required
to determine their overall effectiveness.
Joint Power Rx
- A formula with powerful herbs and nutrients by Ray Sahelian, M.D.
Because osteoarthritis is so debilitating, glucosamine and chondroitin alone are often not enough. This powerful osteoarthritis formula includes several additional herbal extracts and nutrients that play a role in joint health.
Joint Power
Rx Supplement Facts:
Serving Size: 4 Capsules
Servings Per Container: 30 (1 month supply)
Glucosamine
sulfate (from shellfish)
is helpful
in osteoarthritis particularly if combined with other nutrients.
Chondroitin
sulfate
is a major constituent of
cartilage providing structure, holding water and
nutrients, and allowing other molecules to move through cartilage.
MSM appears to be a promising nutrient in osteoarthritis
and possibly certain types of allergies. A new study finds the combination
of MSM and glucosamine to having synergistic effects in osteoarthritis.
CMO complex is also known as
cetyl myristoleate. Many formulas over the counter promoted for joint
health include CMO.
Boswellia serrata
extract
has been found helpful in knee osteoarthritis.
Curcumin extract
from the turmeric root.
Cat's claw extract
herb
from South America.
Devil's claw extract
herb from South America.
Grape seed extract
supplement
Sea cucumber
extract
There are a number of nutritional supplements that should be considered, either alone or together. These include the basic vitamins such as vitamins C and D, along with important omega-3 anti-inflammatory fatty acids such as those found in fish oils, EPA and DHA. SAM-e, a nutrient often used as a natural antidepressant, may offer some benefits but I suggest you keep the dosage low to avoid insomnia. Pomegranate, ginger and curcumin (the active extract from turmeric, found in curry spice) are foods and spices to consider adding to one's diet on a regular basis. Additional beneficial nutrients and herbs are found in Joint Power Rx, a formula that has many of the ingredients important to maintain joint health. These nutrients can be helpful in dogs and other animals with degenerative joint problems. Treatment and prevention of a degenerative joint condition is different than that of rheumatoid arthritis. Osteoarthritis is the common form of arthritis associated with aging, while rheumatoid arthritis is an autoimmune disorder in which the immune system mistakenly attacks the lining of the joints, leading to inflammation, pain and stiffness.
Chondroitin sulfate or sulphate
Back in the mid 1990s the America
public became aware of effective nutritional alternatives to standard medical
drugs for the treatment of osteoarthritis. Glucosamine was the first nutrient
that became popular. Since then, many other nutrients and herbs have been
promoted, including chondroitin sulfate, a major constituent of
cartilage providing structure, holding water, and allowing other molecules to
move through cartilage—an important property, as there is no blood supply to
cartilage. In degenerative joint disease, such as osteoarthritis, there is a
loss of chondroitin sulfate as the cartilage erodes. In a study
performed at University of Genova Medical School, in Italy, 12 individuals with
arthritis of the hands were treated with 800 mg/day of chondroitin sulfate plus
naproxen, and compared to 12 others who were given naproxen only. Naproxen is an
anti-inflammatory medicine similar to Motrin and sold over the counter as Aleve.
X-rays of the hands were done at the start of the study and again after 24
months. In both groups, degeneration of joints showed a general tendency to
increase over time, however, the damage was much lower in those treated with
chondroitin sulfate plus naproxen than in patients taking naproxen alone.
Dr. Sahelian says: Although chondroitin by itself did
not stop the continuing damage to joints, it did slow the progression of the
osteoarthritis. Glucosamine supplements are known to enhance joint health in those
with arthritis, and it seems reasonable to take both supplements. The most common dose of glucosamine is 1500 mg a day
while that of chondroitin is 500 to 1000 mg per day.
Effects of an Oral Administration of
Glucosamine Chondroitin Quercetin Glucoside on the Synovial Fluid
Properties in Patients with Osteoarthritis and Rheumatoid Arthritis.
Biosci Biotechnol Biochem. 2009.
The effects of an orally administered combination of a glucosamine
chondroitin quercetin glucoside supplement on the synovial fluid
properties of patients with osteoarthritis and rheumatoid arthritis were
investigated. Forty-six osteoarthritis and twenty-two rheumatoid
arthritis patients were administered with the glucosamine chondroitin
quercetin supplement orally for 3 months. The
osteoarthritis patients showed a significant improvement in pain
symptoms, daily activities (walking and climbing up and down stairs),
and changes in the synovial fluid properties with respect to the protein
concentration, molecular size of hyaluronic acid, and chondroitin
6-sulphate concentration. However, no such effects
were observed in the rheumatoid arthritis patients. These results suggest
that the glucosamine chondroitin quercetin supplement exerted a special
effect on improving the synovial fluid properties in osteoarthritis
patients. The dosage was 1200 mg glucosamine hydrochloride,
300 mg shark cartilage (consisting of about 100 mg of chondroitin), and
45 mg of quercetin.
Intermittent treatment of knee
osteoarthritis with oral chondroitin sulfate: a one-year, randomized,
double-blind, multicenter study versus placebo.
Osteoarthritis Cartilage. 2004.
A total of 120 patients
with symptomatic knee osteoarthritis were randomized into two groups
receiving either 800mg chondroitin sulfate or placebo per day for two
periods of 3 months during 1 year. Primary efficacy outcome was Lequesne's
algo-functional index (AFI); secondary outcome parameters included VAS,
walking time, global judgment, and paracetamol consumption. AFI decreased significantly
by 36% in the chondroitin sulfate group after 1 year as compared to 23% in
the placebo group. Radiological progression at month 12 showed significantly
decreased joint space width in the placebo group with no change in the chondroitin sulfate group. Tolerability was good with only minor adverse
events identically observed in both groups. This study
provides evidences that oral chondroitin sulfate decreased pain and
improved knee function. The 3-month intermittent administration of
800mg/day of oral chondroitin sulfate twice a year does support the
prolonged effect known with symptom-modifying agents for osteoarthritis.
Fish oils, omega-3 fatty acids
A multicenter study of the effect of dietary supplementation with fish oil
omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis.
J Am Vet Med Assoc. 2010. Pet Nutrition Center, Hill's Pet
Nutrition Inc, PO Box 1658, Topeka, KS, USA.
To determine the effects of feeding a diet supplemented with fish oil omega-3
fatty acids on carprofen dosage in dogs with osteoarthritis. Results suggest
that in dogs with chronic osteoarthritis receiving carprofen because of signs of
pain, feeding a diet supplemented with fish oil omega-3 fatty acids may allow
for a reduction in carprofen dosage.
Glucosamine and
MSM work better together for arthritis
The combination of glucosamine and methylsulfonylmethane
-- better known as MSM -- appears to be
more effective against osteoarthritis than either nutrient alone. Although the individual
nutrients did improve pain and swelling in patients' affected joints, the
combined therapy was more effective than MSM or glucosamine alone in reducing these symptoms and improving the
function of joints. In a clinical trial conducted at at the Institute of
Medical Sciences in Hyderabad, India, 118 patients with mild to moderate osteoarthritis
were treated three times daily with either 500 milligrams of glucosamine, 500
milligrams of MSM, a combination of both, or an inactive
placebo. After 12 weeks of treatment, the average pain score had fallen from
1.7 to 0.6 in the glucosamine-only group. In MSM-only participants, it fell
from 1.5 to 0.7. However, in the combination group, it fell from 1.7 to 0.3. The
researchers also found that the combination treatment had a faster effect on
pain and inflammation compared to glucosamine alone. All of the treatments were
well tolerated. Clinical Drug Investigations, June 2004.
Does glucosamine by itself help osteoarthritis ?
The studies have been mixed. Some have shown glucosamine by itself is a natural remedy for osteoarthritis while other studies
have come to the conclusion that glucosamine by itself is not much help. I
prefer using glucosamine along with chondroitin, msm, cmo, and other nutrients.
Is MSM a good natural osteoarthritis treatment?
Anecdotal reports indicate that MSM may be helpful
as a natural osteoarthritis treatment but I have not seen few human studies to
confirm this treatment.
Pomegranate benefit
Pomegranate
fruit extracts can block enzymes that contribute to osteoarthritis according to
a Case Western Reserve University School of Medicine study published in the
September 2005 issue of the Journal of Nutrition. The study looked at the
ability of an extract of pomegranate fruit against Interleukin-1b (IL-1b), a
pro-inflammatory protein molecule that plays a key role in cartilage degradation
in osteoarthritis.
Vitamin C
I am a 65 year old male bothered by osteoarthritis symptoms. I have taken
Vitamin C in the 1-2 gram range for many years. I have been researching
osteoarthritis diets and remedies online and discovered new sites that say
research on guinea pigs show high doses of vitamin C worsen osteoarthritis. Do
you have any advice on this?
I have not seen such studies in humans. Most people can take 100
to 1000 mg of vitamin C daily without major side effects. In fact, one study
shows some benefit.
The effects of vitamin C supplementation on
incident and progressive knee osteoarthritis: a longitudinal study.
Public Health Nutr. 2010. Peregoy J, Wilder FV.1 Department of
Epidemiology, College of Public Health, University of South Florida, Clearwater,
FL, USA.
To evaluate the association between vitamin C supplementation and the
incidence and progression of radiographic knee osteoarthritis (OA). Prospective
cohort study. Male and female participants aged 40 years and above. Individuals
without baseline knee OA who self-reported vitamin C supplement usage were 11 %
less likely to develop knee OA than were those individuals who self-reported no
vitamin C supplement usage.
Vitamin D may be of benefit
Boston researchers report a link between low
serum levels of vitamin D and decreased knee function in patients with
osteoarthritis of the knee. At the annual meeting of the American College of
Rheumatology in San Antonio, researchers presented findings from 221 subjects
recruited from the Boston VA Medical Center. All had knee arthritis and reported
knee pain on most days in the month before they joined the study. The
investigators measured blood levels of vitamin D at the start and again after 15
and 30 months. They compared change in vitamin D levels with changes in knee
pain, physical function and muscle strength during the 30-month study period.
Low levels were associated with higher levels of pain and disability and to a
lesser extent muscle weakness. The researchers also found that about 50 percent
of the population were deficient in vitamin D.
Exercise and
osteoarthritis symptoms
Moderate exercise can help older adults with osteoarthritis ease
their pain and fatigue. Strength training, for instance weight training,
can help ease pain and improve physical functioning in people with
osteoarthritis of the knee.
Adults who suffer from knee osteoarthritis may want to go without shoes
when they can. Walking in shoes increases loads on knee and hip joints
in patients with osteoarthritis of the knee.
Other products
formulated by Ray Sahelian, M.D. and found at
Advance
Physician Formulas online vitamin store:
Mind Power Rx for healthy brain
function and memory
with DMAE and
Ginkgo biloba.
Prostate Power Rx for optimal prostate health with
saw palmetto extract.
Eyesight Rx for healthy vision, results sometimes seen within
hours.
5-HTP 50 mg for
serotonin
support.
Acetyl-l-Carnitine 300 mg - mind
and memory support, antioxidant.
CoQ10 60 mg for healthy energy metabolism and heart
function.
Tongkat Ali 400 mg -
herbal libido enhancer from Malaysia.
Mangosteen - contains powerful xanthones.
Serrapeptase - blood clot dissolver.
Metabolic causes
of osteoarthritis
The exact physiological causes of osteoarthritis are not fully understood. Multiple
factors (e.g., heredity, trauma, and obesity) interact to cause this disorder.
Any event that changes the environment of the chondrocyte has the potential to cause
it. Although usually occurring as a primary disorder, osteoarthritis can occur
secondary to other processes. The pathophysiology involves a combination of mechanical,
cellular, and biochemical processes. The interaction of these processes leads to changes
in the composition and mechanical properties of the articular
cartilage. Cartilage is
composed of water, collagen, and proteoglycans. In healthy cartilage, continual internal
remodeling occurs as the chondrocytes replace macromolecules lost through degradation.
This process becomes disrupted in osteoarthritis, leading to increased degenerative
changes and an abnormal repair response.
For overweight people hobbled by knee osteoarthritis,
losing even one pound can diminish the stress the knees take with every step.
Osteoarthritis symptom
The following are some osteoarthritis symptoms:
Aching pain, stiffness, or difficulty moving the joint.
The pain often gets worse with overuse and may occur in the evening. In late
stages of osteoarthritis, the pain can occur at rest.
Osteoarthritis of Fingers : Bone enlargements in the
fingertips (first joint) are common. These are called Heberden nodes. They are
usually not painful.
Hip osteoarthritis : The hips are major weight-bearing
joints. Involvement of the hips may be seen more in men. Farmers, construction
workers, and firefighters have been found to have an increased incidence of hip
osteoarthritis. Heavy physical workload contributes to osteoarthritis of the hip
and knee. Repetitive squatting and kneeling may promote knee osteoarthritis.
Spine Osteoarthritis : this can cause bone spurs or osteophytes, which can pinch nerves and cause pain and potentially weakness in
the arms or legs.
Osteoarthritis pain usually worsens when the temperature drops or when the barometric pressure increases. Some sufferers say their pain is better in climates that are warm and sunny. It's not fully clear why temperature and barometric pressure might influence joint pain. Cold temperatures may, for instance, affect joint range of motion, or the flow of the synovial fluid that lubricates the joints.
What is the standard medical
osteoarthritis treatment?
Acetaminophen and nonsteroidal
anti-inflammatory drugs, such as ibuprofen, remain first-line traditional medications for the
treatment of osteoarthritis. Naproxen, also sold as Aleve, might increase risk
of heart attack or stroke. Osteoarthritis medications such as
cyclooxygenase-2 inhibitors (COX-2) with the brand name Vioxx and Celebrex were
thought to offer a safe alternative, but now we realize that they can be
dangerous. Salsalate (Disalcid) or
choline magnesium trisalicylate (Trilisate) are good osteoarthritis medicine
alternatives. Complementary medication for osteoarthritis use has increased.
Recent studies indicate that common
osteoarthritis medications such as acetaminophen may not be effective after all.
Long-term, habitual use of the painkiller acetaminophen
-- known as paracetamol in many parts of the world -- may cause a decline
in kidney function in some people, according to a study of middle-aged
women. Overall, one in 10 of the 1,700 women studied over 11 years
experienced a 30 percent decline in their kidney's filtration function.
Acetaminophen, which is sold under the brand name Tylenol by a subsidiary
of Johnson & Johnson and is also marketed generically, was alone among
commonly used painkillers to show an association with kidney impairment.
Approximately one third of all hospitalizations and
deaths related to gastrointestinal bleeding can be attributed to the use of
aspirin or nonsteroidal anti-inflammatory agents (NSAIDs) painkillers like
ibuprofen. Moreover, up to one third of these painkiller-related incidents may
be due to low-dose aspirin. Based on data from previous studies, the use of
externally applied NSAIDs -- a group of anti-inflammatory drugs that
includes ibuprofen and ketoprofen -- don't help patients with osteoarthritis
over the long term. After 2 weeks, these so-called topical NSAIDs are no
better than inactive "placebo" lotions for the treatment of
osteoarthritis.
Joint Cracking
Your mother always said, "Don't crack your knuckles - you'll get
arthritis." Well, she was off the mark. Cracking joints is not detrimental to
bone health. On the contrary, it may actually help ward off joint trouble. Dr.
Tyler Cymet and colleagues from Johns Hopkins University in Baltimore determined
the incidence of osteoarthritis in 100 men and women whose average age was 59.
They compared the incidence in those who cracked their joints and those who
didn't. Osteoarthritis occurred significantly more often in those who said they
never cracked their joints. People who said they cracked their neck, or their
back, hips or knees, had less osteoarthritis than those who didn't.
Diagnosis and lab tests
The principal disease hallmarks for assessment of osteoarthritis are
still clinical observation and x-ray findings. However, the efficacy of
therapeutic interventions is complicated by the time required to observe
radiographic signs, useful for both diagnosis and assessment. Thus, laboratory
markers have received growing attention in recent years, in an attempt to
improve diagnosis, assessment of disease activity and severity, and evaluation
of therapeutic effects. Many biomarkers have been proposed, in particular those
reflecting cartilage and bone turnover and synovitis. Among these, COMP,
antigenic keratan sulphate, hyaluronan, YKL-40, type III collagen N-propeptide,
and urinary glucosyl-galactosyl pyridinoline appear to be the most promising.
However, serum or urinary determinations of these molecules are difficult to
interpret adequately due to their complex metabolism. New ultrasensitive methods
for C-reactive protein
have improved the usefulness of this marker, especially in the assessment of
disease activity. Routine examination of synovial fluid is still essential for
diagnosis and includes leukocyte count and crystal detection; specialized
testing includes the evaluation of the levels of markers of local inflammation
such as metalloproteinases and cytokines, which appear to be crucial to the
pathogenesis of osteoarthritis.
Meniscus damage as cause
The meniscus performs an important function in the joint and
removing it (either in part or whole) enhances the rate of structural
change within the joint leading to osteoarthritis. During knee surgery,
keeping the meniscus is better for patients with osteoarthritis. In the
absence of symptoms such as a locked knee, it is preferable to keep as
much of the meniscus as possible.
Exercise and movement
People suffering from creaky knees may want to give Tai Chi a try.
Researchers have found that practicing the Chinese mind-body exercise
leads to improvements in pain, function and even mental health for
people with osteoarthritis of the knee. Some of these benefits persisted
for a full year after the study began -- months after people had stopped
doing the exercises. Arthritis & Rheumatism, 2009.
Older people with osteoarthritis are more likely to hang on to good physical function if they exercise on a regular basis. In a two-year study of more than 5,700 older adults with osteoarthritis, researchers at Northwestern University in Chicago found that men and women who were consistently active were less likely to develop physical limitations that interfered with their day-to-day lives.
Osteoarthritis Research Update
In a study published in the New England Journal of Medicine,
glucosamine plus chondroitin sulfate did not provide significant relief from
osteoarthritis pain among all participants. However, a smaller subgroup of study
participants with moderate-to-severe pain showed significant relief with the
combined supplements. Researchers led by rheumatologist Daniel O. Clegg, MD, of
the University of Utah, School of Medicine, Salt Lake City, conducted the 4-year
study known as the Glucosamine / chondroitin Arthritis Intervention Trial (GAIT)
at 16 sites across the United States.GAIT enrolled nearly 1,600 participants
with documented osteoarthritis of the knee. Participants were randomly assigned
to receive one of five treatments daily for 24 weeks: glucosamine alone (1,500
mg), chondroitin sulfate alone (1,200 mg), glucosamine and chondroitin sulfate
combined (same doses), a placebo, or celecoxib (200 mg). Celecoxib is an
FDA-approved drug for the management of osteoarthritis pain and served as a
positive control for the study. (A positive control is a treatment that
investigators expect participants to respond to in a predictable way; it helps
validate study results.) A positive response to treatment was defined as a 20
percent or greater reduction in pain at week 24 compared to the start of the
study. The researchers found that participants taking celecoxib experienced
statistically significant pain relief, as expected, versus placebo -- about 70
percent of those taking celecoxib versus 60% taking placebo had a 20% or greater
pain reduction. For all participants, there were no significant differences
between the other treatments tested and placebo. However, for participants in
the moderate-to-severe pain subgroup, glucosamine combined with chondroitin
sulfate provided statistically significant pain relief compared to placebo --
about 79% in this group had a 20% or greater pain reduction compared to 54% for
placebo. In the subgroup of participants with mild pain, glucosamine and
chondroitin sulfate together or alone did not provide statistically significant
relief compared to placebo. On entering the study, a participant's level of pain
was assessed as either mild or moderate to severe using standard pain assessment
tools and scales, such as the Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC). Of the 1,583 study participants, 78% were in the
mild pain subgroup and the other 22% were in the moderate-to-severe pain
subgroup. Level of pain was evaluated at weeks 4, 8, 16, and 24 using the WOMAC
scale and other tools. In addition to taking their daily study treatment,
participants could take up to 4,000 mg of acetaminophen daily for pain, except
for the 24 hours before they were assessed by study staff. Few side effects from
any of the treatments were reported. Those reported were generally mild, such as
upset stomach, and distributed evenly across the treatment groups. The GAIT team
continues their research with a smaller study to see whether glucosamine and
chondroitin sulfate can alter the progression of osteoarthritis, such as
delaying the narrowing of the joint spaces. About one-half of the participants
in the larger GAIT study were eligible to enroll in this ancillary study. The
results are expected in about a year.
Glucosamine, chondroitin sulfate, and the two in combination for painful
knee osteoarthritis.
N Engl J Med. 2006. Clegg DO, Reda DJ, Harris CL,
Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson
CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor
JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz
RW, Williams HJ. Division of Rheumatology, University of Utah School of
Medicine, Salt Lake City, UT
Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The
multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine /
chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and
safety as a treatment for knee pain from osteoarthritis. We randomly assigned
1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of
glucosamine daily, 1200 mg of chondroitin sulfate daily, both glucosamine and
chondroitin sulfate, 200 mg of celecoxib daily, or placebo for 24 weeks. Up to
4000 mg of acetaminophen daily was allowed as rescue analgesia. Assignment was
stratified according to the severity of knee pain (mild ] vs. moderate to
severe). The primary outcome measure was a 20 percent decrease in knee
pain from baseline to week 24. The mean age of the patients was 59
years, and 64 percent were women. Overall, glucosamine and chondroitin sulfate
were not significantly better than placebo in reducing knee pain by 20 percent.
As compared with the rate of response to placebo (60.1 percent), the rate of
response to glucosamine was 3.9 percentage points higher, the rate of response
to chondroitin sulfate was 5.3 percentage points higher, and the rate of
response to combined treatment was 6.5 percentage points higher. The rate of
response in the celecoxib control group was 10.0 percentage points higher than
that in the placebo control group (P=0.008). For patients with
moderate-to-severe pain at baseline, the rate of response was significantly
higher with combined therapy than with placebo (79.2 percent vs. 54.3 percent. Adverse events were mild, infrequent, and evenly distributed among the
groups. Glucosamine and chondroitin sulfate alone or in combination
did not reduce pain effectively in the overall group of patients with
osteoarthritis of the knee. Exploratory analyses suggest that the combination of
glucosamine and chondroitin sulfate may be effective in the subgroup of patients
with moderate-to-severe knee pain.
Soy protein may alleviate osteoarthritis symptoms.
Phytomedicine. 2004.
Alternative and complementary therapeutic approaches, such as the use of a
wide array of herbal, nutritional, and physical manipulations, are becoming
popular for relieving symptoms of osteoarthritis. The present study evaluated
the efficacy of soy protein supplementation in relieving the pain and discomfort
associated with osteoarthritis. One hundred and thirty-five free-living
individuals (64 men and 71 women) with diagnosed osteoarthritis or with
self-reported chronic knee joint pain not attributed to injury or rheumatoid
arthritis were recruited for this double-blind, placebo-controlled, parallel
design study. Study participants were assigned randomly to consume 40 g of
either supplemental soy protein or milk-based protein (MP) daily for 3 months.
Overall, soy protein improved osteoarthritis -associated symptoms such as range
of motion and several factors associated with pain and quality of life in
comparison to MP. However, these beneficial effects were mainly due to the
effect of soy protein in men rather than women. This study is the first to
provide evidence of possible beneficial effects of soy protein in the management
of osteoarthritis. Examining and verifying the long-term effects of soy protein
on improving symptoms of osteoarthritis, particularly in men, is warranted.
Just because aspirin, ibuprofen and similar pain relief medications can be
purchased at a local supermarket or gas station without a prescription does not
mean people should not take basic precautions when using them, according to the
National Consumers League and the US Food and Drug Administration. The two
groups joined together to launch on Thursday their "Take With Care" campaign to
educate consumers about the safe use of nonprescription pain relievers.
"Although these medicines are safe when taken as directed, many consumers don't
realize the potency of OTC pain relievers," Peter J. Pitts, associate
commissioner of the Food and Drug Administration said during the campaign
launch. Some of the potentially serious side effects associated with the misuse
of over-the-counter pain relievers include an increased risk of liver problems
and kidney damage.
High levels of fat and (n-6) fatty acids in cancellous
bone in osteoarthritis.
Plumb MS, Aspden RM. Lipids Health Dis. 2004.
Osteoarthritis is strongly linked with obesity and patients with
osteoporosis (OP) have a low body mass index. Anecdotal evidence, clinical and
laboratory, suggests that Osteoarthritis bone contains more fat. However,
conversion of osteoblasts to adipocytes is reported in OP and this would suggest
that the more porous OP cancellous bone would have a high fat content.
Objectives: To test the hypothesis that Osteoarthritis bone contains more fat
than OP bone. Methods: Cores of cancellous bone were obtained from femoral heads
of patients undergoing surgery for either Osteoarthritis or OP. Lipids were
extracted using chloroform-methanol, weighed and expressed as a fraction of core
mass and volume. A fatty acid analysis was performed using gas chromatography.
Osteoarthritis bone contained twice as much fat per unit volume of
tissue as OP. Levels of n-6 fatty acids were elevated in osteoarthritis,
especially arachidonic acid (C20:4 n-6) which was almost double that found in
OP. These data support the hypothesis that lipids may play a
significant role in the pathogenesis and may provide part of
the key to understanding why osteoarthritis and OP lie at opposite ends of the
spectrum of bone masses.
Osteoarthritis natural treatment with supplements herbs
vitamins questions
What's the difference between osteoarthritis and rheumatoid arthritis
is simple terms?
Osteoarthritis is the gradual deterioration of cartilage in joints
due to wear and tear and aging while rheumatoid arthritis is an autoimmune
disorder that can strike at any age.
Does Lyprinol work in osteoarthritis?
It may, there is some research available at the
Lyprinol web page.
I've heard that hyaluronic acid supplement is a good alternative
osteoarthritis treatment.
As of February 2010, I have not seen any studies with oral hyaluronic
acid as an alternative osteoarthritis treatment.
A physician from Bulgaria recommends that I take
tribulus terrestris, one of the common
sexual enhancers
found in libido enhancing products,
to improve osteoarthritis in my hip. Would you recommend
this herb for my condition?
I can't make individual recommendations. I have not heard of tribulus terrestris being used for osteoarthritis.
Is
white willow bark
helpful for joint pain?
I have not studied this herb in enough detail yet.