Oxiracetam drug by Ray Sahelian, M.D. Memory improvement with Oxiracetam medication
Nootropic drugs, such as aniracetam, etiracetam, nefiracetam, oxiracetam, piracetam, pramiracetam, and rolziracetam are used in the treatment of dementia and cognitive enhancement. These nootropic agents were discovered in the 1960s.
Oxiracetam human study
Treatment of cognitive impairment secondary to degenerative dementia.
Effectiveness of oxiracetam therapy.
Acta Neurol (Napoli). 1993 Feb;15(1):44-52. Department of General Medicine,
Ospedale S. Orsola, Brescia.
The effectiveness of Oxiracetam (1600 mg/day) versus placebo was assessed in
a group of 96 out-patients suffering from cognitive disorders secondary to
primary degenerative dementia. The study lasted twelve months and was performed
in two stage, a) double-blind (26 weeks) and b) open study (26 weeks). The
patients treated with Oxiracetam showed a statistically significant improvement
of simple reaction time and cognitive function detected by the Attention matrix.
In the placebo group after twelve months a significant worsening of cognitive
and global function was observed in comparison with baseline scores. The
patients themselves appeared in favor of Oxiracetam. The drug tolerability
proved to be very good for the whole duration of the treatment. The authors
believe that Oxiracetam favorably acts on the symptoms of senile cerebral
deterioration and can improve the capability of information processing, as
suggested by the better performances obtained at the reaction time test and at
the Attentional Matrix test.
Animal studies with Oxiracetam
Oxiracetam prevented the scopolamine but not the diazepam induced memory
deficits in mice.
Behav Brain Res. 2002 Jul 18;133(2):395-9. Institute of Physiology, Academy
of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech
Republic.
In mice, the elevated plus-maze paradigm was used to investigate the effect of
scopolamine hydrobromide and diazepam and their interaction with oxiracetam on
the retrieval of spatial memory trace. Experiment 1: Scopolamine and
diazepam given 30 min before the retention session significantly prolonged the
transfer latency as compared with the saline treated mice and those given the
lowest dose of scopolamine and diazepam. Experiment 2: Oxiracetam administered
immediately after the acquisition session prevented the scopolamine induced
prolongation of the transfer latency. Thus, oxiracetam forestalled the
impairment of retrieval of memory trace: the animals were able to remember the
spatial configuration of the plus-maze. On the contrary, oxiracetam was not
effective in the diazepam treated mice. We suggest that beneficial effect of
oxiracetam might be confounded or blocked by the anxiolytic effect of diazepam.
Oxiracetam emalls
Q. What are your thoughts on the efficacy of oxiracetam? I've been taking an 800
mg capsule 3-4 times a week for four years and definitely notice an improvement
in mental functions such as quicker thought processes and improved memory.
A. I prefer to use natural supplements since they provide good
benefits. I personally have not tried oxiracetam.
This oxiracetam page was last updated Feb 2008.
Additional nootropic links
Aniracetam nootropic
Piracetam nootropic