Paeonol health benefit, review of research studies
February 1 2017

Paeonol is a phenolic component from the root bark of Paeonia moutan. Paeony root has long been used for its anti-inflammatory effects. Paeonol may be a major ingredient for the anti-inflammatory effect of paeony root. As of 2016, we have not seen any human studies with this substance.

Paeonol as anti-inflammatory agent
Inhibition of LPS-Induced iNOS, COX-2 and Inflammatory Mediator Expression by Paeonol through the MAPKs Inactivation in RAW 264.7 Cells.
Am J Chin Med. 2009; Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Iksan, Chonbuk, Republic of Korea.
We evaluated the in vivo anti-inflammatory and analgesic activities of orally administered paeonol in mice, and also investigated the anti-inflammatory activity of paeonol in a cell line. Paeonol significantly reduced the edema induced by arachidonic acid in rats. Paeonol appears to have potential as a treatment for inflammatory disease and analgesic.

Paeonol research studies, synergistic anti cancer effect with chemotherapy drug
Synergistic effect of paeonol and cisplatin on esophageal cancer cell lines.
Dig Liver Dis. 2008. Department of Oncology, Hefei, PR China.
Paeonol, a phenolic component from the root bark of Paeonia moutan, has shown great promise in antitumour activities in our previous studies. The present study was designed to investigate whether paeonol has synergistic effect with cisplatin on the growth-inhibitory of human oesophageal cancer cell lines and the possible mechanism. Paeonol, in combination with cisplatin, had a significantly synergistic growth-inhibitory effect on oesophageal cell line, which may be related to apoptosis induction.