Pancreatin enzyme supplement
June 20 2017 by
Ray Sahelian, M.D.

Pancreatin is a combination of enzymes produced by the pancreas. To treat pancreatic exocrine insufficiency, physicians often prescribe enterically coated pellets of pancreatin to be taken with meals. The enzymes in pancreatin may come from pork, beef or vegetables. Pancreatin is generally used in patients with cystic fibrosis. Pancreatin contains amylase, lipase, and protease. Amylase breaks down starch, lipase breaks down fats, and proteases metabolize complex proteins. See digestive enzymes for more information on this topic.

Pancreatin use in chronic pancreatitis
Chronic pancreatitis is the major cause of pancreatic insufficiency which can be compensated by pancreatic enzyme replacement therapy. There are now available a great number of pancreatic enzyme preparations, but encapsulated enteric-coated microspheres and minimicrospheres are considered the enzyme treatment of choice.

Pancreatology. 2013. A 51-week, open-label clinical trial in India to assess the efficacy and safety of pancreatin 40000 enteric-coated minimicrospheres in patients with pancreatic exocrine insufficiency due to chronic pancreatitis. Patients received pancreatin (Creon ® 40000 MMS™) at a dose of 80,000 Ph. Eur. lipase units with each of three main meals/day and 40,000 with each of up to three snacks/day. In patients with PEI due to CP, treatment with pancreatin for one year was associated with significant improvements in fat absorption, nitrogen absorption, and nutritional parameters, improvements in clinical symptoms, and a favorable safety and tolerability profile.

Other uses of Pancreatin enzyme
Pancreatin may in some cases help with food allergies, celiac disease, autoimmune disease, cancer, and weight loss.

Pancreatic surgery
Disturbance of pancreatic function can persist for several weeks following pancreatic surgery in which case the use of pancreatic enzymes such as pancreatin could be helpful.

Dose-dependent effect of pancreatin replacement upon the pancreatic function in the period after pancreatic surgery. Magy Seb. 2001 Dec;54(6):347-50. Szegedi Tudományegyetem Altalános Orvosi Kar, Sebészeti Klinika.
A placebo-controlled trial of enteric-coated pancreatin (Kreon 25,000 U lipase [A] and Kreon 10,000 U lipase [B]; 3 x 1 caps/day) was performed for 2 weeks following pancreatic surgery (resection or drainage operation in each group). A total of 60 patients were randomized, 20 to A and B pancreatin groups each, and 20 to the placebo group. CONCLUSION: The results suggest that dose-dependent enteric-coated pancreatin treatment after pancreatic surgery may lead to rapid improvement in the exocrine pancreatic function, probably by reducing the cholecystokinin response to food stimulation. This is an important indication for enteric-coated pancreatin medication.

Pancreatin Power by Source Naturals
Pancreatin Power is a formulation of Pancreatin 10X proteases, lipases and amylases which support systemic functions in the bloodstream by metabolizing proteins, lipids and saccharides.