Papaya leaf extract and fruit anti cancer benefit
June 20 2016 by Ray Sahelian, M.D.

The papaya fruit is used in The Gambia at the Royal Victoria Hospital, Banjul in the Pediatric Unit as a component of burns dressings. The pulp of the papaya fruit is mashed and applied daily to full thickness and infected burns. It appears to be effective in loosening necrotic tissue, preventing burn wound infection, and providing a granulating wound suitable for the application of a split thickness skin graft. Possible mechanisms of action include the activity of proteolytic enzymes chymopapain and papain, as well as an antimicrobial activity.

Antioxidant
Pharm Biol. 2013. Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe2+-induced oxidative stress in rat pancreas in vitro.

Cancer protection
Papaya leaf extract and its tea have dramatic cancer-fighting properties against a broad range of tumorsfd. University of Florida researcher Nam Dang and colleagues in Japan, in a report published in the Journal of Ethnopharmacology, documented papaya's anticancer effect against tumors of the cervix, breast, liver, lung and pancreas.The researchers used an extract made from dried papaya leaves, and the effects were stronger when cells received larger doses of papaya leaf tea. Dang and the other scientists showed that papaya leaf extract boosts the production of key signaling molecules called Th1-type cytokines, which help regulate the immune system.

Neuro Endocrinology Lett. 2013. Papaya preparation (Caricol) in digestive disorders. Papaya (Carica papaya) is used as a natural remedy in abnormal digestion in tropical and industrialized countries. Besides this wide distribution little evidence has been produced with reference to its physiological effect in humans and the proof of efficacy. Former clinical observations had revealed positive effects for patients with constipation, heartburn, and symptoms of irritable bowel syndrome (IBS) after eating papaya preparations. In line with these former positive clinical observations, we studied the clinical effects of the papaya preparation Caricol in a double blind placebo controlled study design. In this study the participants were volunteers, with chronic (prevailing) indigestions and dysfunctions in the gastrointestinal tract. During the trial the intake of the substance of intent and placebo was 20 ml daily for 40 days. The endpoints were the frequency of 22 symptoms recorded before and after the documented intake recorded by questionnaire. The symptoms "Constipation", "Bloating", and "Heartburn" were defined as primary and frequency of "painful (straining) bowel movements" as secondary endpoint. The participation ended after the intake period within two days ("early returnees"). Wash out effects were observed in "late returnees", who returned with a delay of 8.6 (5.95 days). In the verum group early returnees revealed statistically significant improvements of the symptoms "constipation" and "bloating". The analysis of "heartburn" felt short of significant improvement because of the small number of included cases with this criteria. None of the significant benefits were observed after the washout phase. We conclude from these results, that the papaya preparation (Caricol) contributes to the maintenance of digestive tract physiology. It ameliorates various functional disturbances, like symptoms of IBS.

Questions
I have been taking Creon for digestion. My doctor thinks I may have mild pancreatitis. Because I do not want to eat meat, I am concerned about taking Creon, a pig product. I saw Source Natural Daily Essential Enzymes and my dr. says I can switch to that and see if it works for me. I am allergic to latex and I wonder if I can take a product with papaya in it as I have read people allergic to latex are also allergic to papaya. Would SN Daily Essential Enzymes be as effective as Creon? Any information you can provide will be greatly appreciated.
   A. It is not easy to predict whether the digestive enzyme product would be as effective as Creon. The only way to know is by trying it. As far as the potential allergy situation, again it is not easy to know for sure. Papayas have substances called chitinases that are associated with the latex-fruit allergy syndrome. Some websites mention evidence of a cross-reaction between latex and papaya ingestion. However, the digestive enzyme formula has enzymes derived from the fruit and does not contain all the substances found in the fruit. The decision to use this product rests with you and your doctor.