Pectin supplement health benefit, should you take this product, and if so how much? by Ray Sahelian, M.D.
Feb 14 2014

 

Pectin is a grouping of acidic structural polysaccharides, found in fruits and vegetables and mainly prepared from 'waste' citrus peel and apple pomace. Grapefruit pectin and apple pectin supplements are sold in health food stores. Pectin has many health benefits including a prebiotic effect, lowering cholesterol and glucose levels and may also have potential for weight management. Diet Rx has apple pectin as one of the ingredients.
 

buy Grapefruit Pectin supplement, 1000 mg

Buy Pectin Grapefruit

Grapefruit Pectin is a natural fiber substance derived from the pulp and peel of the grapefruit. It is an excellent source of water-soluble fiber that has a gel-forming effect when mixed with water. It is derived from the Greek word pectos, which means solidified or gelatinated. As a dietary fiber, it supports good intestinal health.

Supplement Info: Grapefruit Pectin 1000 mg each pill
 

buy Grapefruit Pectin supplement to purchase or for more information


Suggested Use: As a dietary supplement, take 1 or 2 grapefruit pectin capsule 1 to 2 times daily, preferably with meals.

 

 

Appetite suppression, does it help in reducing food consumption?
J Food Sci. 2010. A low-calorie beverage supplemented with low-viscosity pectin reduces energy intake at a subsequent meal.


Grapefruit pectin and cholesterol
Eur J Clin Nutr. 2012. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women.

 

The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle.
Clin Cardiol. 1988.
The effect of grapefruit pectin (Citrus paradisi) on plasma cholesterol, triglycerides, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and the low-density lipoprotein:high-density lipoprotein cholesterol ratio was studied. The study design was a 16-week double-blind, crossover (placebo or pectin) using 27 human volunteers screened to be at medium to high risk for coronary heart disease due to hypercholesterolemia. The study did not interfere with the subjects' current diet or lifestyle. Grapefruit pectin supplementation decreased plasma cholesterol 7%, low-density lipoprotein cholesterol 11%, and the low-density lipoprotein:high-density lipoprotein cholesterol ratio 10%. The other plasma lipid fractions studied showed no significant differences.

 

Pectin and cancer prevention or treatment
UK researchers found that particular components of pectin bind to, and possibly inhibit, a protein believed to ease the spread of cancer throughout the body. Modified forms of pectin may perhaps be beneficial in prevention or treatment of cancer. Modified pectin can kill or prevent the spread of tumor cells in the test tube. Certain sugars in pectin bind to galectin-3, a protein on the surface of tumor cells that helps the cells grow and spread throughout the body, and thereby slow or even reverse the spread of cancer cells, Gunning explained. The FASEB Journal, online 2008.

 

BMC Complement Altern Med. 2011. Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin. MCP has immunostimulatory properties in human blood samples, including the activation of functional NK cells against K562 leukemic cells in culture. Unsaturated oligogalacturonic acids appear to be the immunostimulatory carbohydrates in MCP.

 

Prostate cancer
Crystal Jackson, at the University of Georgia, tested different forms of pectin - commercially available fractionated pectin powder, citrus pectin (CP), and pH-modified CP (PectaSol), was tested on hormone- (androgen) responsive and androgen-independent human prostate cancer cells. Fractionated pectin powder induced apoptosis (programmed cell death) by about 40 fold, compared to non-treated cells, for both types of cancer cells. Chemical treatment of the fractionated pectin powder using base (alkali) in order to remove the ester linkages of the pectin structure destroyed the ability of the pectin to induce apoptosis. Treatment of the pectin with pectinmethylesterase enzymes did not affect activity, indicating that the base-sensitive linkages played an important role in the apparent anti-cancer benefits. Both citrus pectin and the pH-modified citrus pectin had no effect on the cancer cells, but heat treatment of citrus pectin resulted in significant levels of apoptosis comparable to FPP.


The ingredient, with worldwide production estimated at 35,000 tonnes a year, is currently widely used as gelling agents in jams, confectionary, and bakery fillings, and stabilisers in yoghurts and milk drinks.

The majority of pectin used currently comes from citrus peel and apple pomace. Other sources of the ingredient, like sugar beet and pumpkin, have remained largely unexploited because of certain undesirable structural properties.

Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure.
Source: Glycobiology. 2007.


Apple pectin has no influence on electrolyte levels
Effect of pectin on some electrolytes and trace elements in patients with hyperlipoproteinemia.
Folia Med (Plovdiv). 1998.
Seventy three patients with hyperlipoproteinemia, aged from 40 to 69 years were treated with a natural product, based on high-esterified pectin granulated with sorbitol. The results of the comparative assessment of the electrolytes (sodium, potassium, chloride, ionised calcium, total and ionised magnesium) failed to reach statistical significance during the administration of the pectin product. Neither did the serum level of trace elements (iron and copper) change significantly during the observed period. The biochemical analysis of the serum level of certain electrolytes and trace elements indicate that daily administration of 15 g of high-esterified apple pectin for a three-month period has no adverse effects. Therefore pectin products can be included in the therapeutic schedule in the treatment of hyperlipoproteinemia.

 

Pectin not helpful in duodenal ulcer
Dietary supplementation with pectin in the maintenance treatment of duodenal ulcer. A controlled study.
Scand J Gastroenterol. 1988.
Patients with recently healed duodenal
ulcers diagnosed by endoscopy were randomly allocated to receive 10 g apple pectin USP powder twice daily, 150 mg ranitidine at night, or one tablet matching ranitidine placebo at night for 6 months. Recurrences occurred in 23 of 27 (85%) patients taking pectin, 6 of 28 (21%) patients taking ranitidine, and 20 of 28 (71%) patients taking placebo. At the doses taken, therefore, dietary supplementation with pectin did not reduce the incidence of duodenal ulcer relapse.

 

Niacin flushing
J Clin Lipidol. 2013. Apple pectin for the reduction of niacin-induced flushing. Niacin, or vitamin B3, when used in high doses can significantly improve the levels of all major lipoproteins. Despite these benefits, the use of niacin is greatly limited secondary to benign yet bothersome cutaneous flushing primarily involving the face and upper extremities. Pretreatment with aspirin or other prostaglandin inhibitors has demonstrated significant reductions in niacin-induced flushing (NIF), but other treatment options are needed. Clinical and anecdotal evidence suggests the ingestion of pectin-containing fruits (eg, apple) mitigates NIF; however, clinical trials evaluating this are nonexistent. That pretreatment with encapsulated apple pectin would limit the incidence, severity, time of initiation, and duration of NIF. We enrolled 100 niacin-na´ve subjects (n = 25 per group) and preteated them in a double-blind manner with apple pectin, apple pectin + aspirin, aspirin, or placebo, followed by a one-time 1000 mg dose of niacin extended-release (niacin ER). Subjects then assessed major flushing parameters hourly for the next 6 hours with a validated visual analog scale.RESULTS:Apple pectin and aspirin each significantly lowered the duration of NIF and produced nonsignificant but positive improvements in all other major flushing parameters compared with placebo. Apple pectin may potentially be an alternative to aspirin for the prevention of NIF. Larger trials are needed to further evaluate the benefit of pectin on NIF.

 

Questions

Q. In regular apple cider vinegar, how much pectin (fiber) is there in a tablespoon of vinegar, and how much do you think is good for you in a day's time.
   A. Pectin is a fiber that is normally removed from apple cider vinegar pills. We can't say how much apple cider vinegar tablets to take, that is a personal decision.

 

I have been using PectaSol for the past year or so to help treat PC (I also underwent a year of ADT). In a study published in Glycobiology, the researcher came to the following conclusions: "Commercially available fractionated pectin powder (FPP) extract induced apoptosis (approximately 40-fold above non-treated cells) in both cell lines [LMCap],[LNCap C4-2] as determined by the Apoptosense assay and activation of caspase-3 and its substrate, poly(ADP-ribose) polymerase. Conversely, citrus pectin (CP) and the ph-modified CP, PectaSol, had little or no apoptotic activity.

 

 have been taking 1000mg grapefruit pectin daily for about a month to help with high LDL levels. On the plus side I have noticed weight loss, and the inflammation and limitations of thumb arthritis and trigger finger totally disappeared! On the minus side--I had developed symptoms that suggest an interstitial cystitis of sorts. Could be coincidental. Was wondering if the acidic nature of grapefruit pectin could be contributing and if so --what measures might you suggest to counter this. Have discontinued GP for 2 weeks now. Cystitis symptoms have dissipated and thumb pain/stiffness starting to return, not to original level yet.
    We have not heard of this potential side effect before and since studies with this supplement in humans are incomplete, it is not easy to know the causes or relationships with the symptoms you mention.