January 20 2016
Urol J. 2013. Anti-urolithiatic effect of ethanolic extract of Pedalium murex linn. fruits on ethylene glycol-induced renal calculi. To evaluate effect of ethanolic extract of Pedalium murex Linn. fruits on experimental model of calcium oxalate nephrolithiasis. Ethanolic extract of Pedalium murex fruits possess significant activity for prevention of renal calculi, kidney stones.
African J Tradit Complement Altern Med. 2013. Evaluation of anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. fruits. This study investigated the possible anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. fruits in selected experimental animal models. Anti-inflammatory activity of Pedalium murex Linn., with doses of 200 mg/kg and 400 mg/kg, p.o., was evaluated by Lambda-carrageenan induced paw oedema in Wistar albino rats; analgesic activity with doses of 280 mg/kg and 560 mg/kg, p.o., was evaluated by hot plate method and acetic acid induced writhing method in Swiss albino mice; and antipyretic activity with doses of 110 mg/kg and 220 mg/kg, p.o., was evaluated in New Zealand white rabbits by injecting gram -ve lipopolysaccharide obtained from E. coli. Results were analysed by one way ANOVA followed by Dunnet's multiple comparison test. Pedalium murex Linn. showed significant anti-inflammatory activity from 15 min to 180 min as compared to vehicle treated animals. It was comparable to diclofenac sodium at 180 min. The extract did not prolong the reaction time on hot plate method but significantly reduced the number of writhing after acetic acid administration. Also the extract did not show any antipyretic activity on lipopolysaccharide induced pyrexia. It is therefore concluded that the ethanolic extract of Pedalium murex Linn. fruits has an anti-inflammatory and peripheral analgesic effects.
Asian Pac J Trop Med. 2011. Pedalium murex Linn.: an overview of its phytopharmacological aspects. Pharmacognosy Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India. Pedalium murex commonly known as Large Caltrops and Gokhru (India) is a shrub found in the Southern part, Deccan region of India and in some parts of Ceylon. Different parts of the plant are used to treat various ailments like, cough, cold and as an antiseptic. Interestingly, P. murex is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in men, nocturnal emissions, gonorrhoea as well as leucorrhoea in women. The plant has also benifited in complications like urinary track disorder as well as gastro intestinal tract disorders. Phytochemically the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin alkaloids. Other phytochemicals reported in the plant includes quercetin, ursolic acid, caffeic acid, amino acids (glycine, histidine, tyrosine, threonine, aspartic acid and glutamic acid) and various classes of fatty acids (triacontanoic acid, nonacosane, tritriacontane, tetratriacontanyl and heptatriacontan-4-one). Pharmacologically, the plant have been investigated for antiulcerogenic, nephroprotective, hypolipidemic, aphrodisiac, antioxidant, antimicrobial and insecticidal activities. From all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic disease. The overall database of our review article was collected from the scientific sources in regards with all the information of the research article for P. murex published so far.