Peony root -- Chinese - health benefit by Ray Sahelian, M.D.
November 20 2016

Paeoniae Radix or Chinese Peony is a commonly used traditional Chinese medicine often for the treatment of rheumatoid arthritis. There are several species of Peony: Paeonia lactiflora, Paeonia suffruticosa, and Paeonia officinalis are some of the ones used as herbs.

Is it safe?
Asian Pac J Trop Biomed. 2013. Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn. The aqueous extract of P. officinalis is safe and possesses antihepatotoxic potential.

Family Paeoniaceae Peony family
Genus Paeonia plant
Species Paeonia lactiflora Pallas Chinese peony

Composition
Paeoniflorin, paeonianins A-E, new dimeric and monomeric ellagitannins from the fruits of Paeonia lactiflora. Peony contains many compounds, including resveratrol.

Alzheimer's disease potential
J Alzheimers Dis. 2015. An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice.

Products sold online
The Tao of Tea, Organic Bai Mudan White Tea, White Peony, 2 oz (57 g)

Peony Officinalis research
Speciation through homoploid hybridization between allotetraploids in peonies (Paeonia).
Proc Natl Acad Sci U S A. 2001.
Department of Botany and Plant Pathology, Michigan State University, East Lansing, MI 48824, USA.
Phylogenies of Adh1 and Adh2 genes suggest that a widespread Mediterranean peony, Paeonia officinalis, is a homoploid hybrid species between two allotetraploid species, Paeonia peregrina and a member of the Paeonia arietina species group. Three phylogenetically distinct types of Adh sequences have been identified from both accessions of P. officinalis, of which two types are most closely related to the two homoeologous Adh loci of the P. arietina group and the remaining type came from one of the two Adh homoeologs of P. peregrina. The other Adh homoeolog of P. peregrina was apparently lost from the hybrid genome, possibly through backcrossing with the P. arietina group.

Peony Lactiflora research
Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats.
J Ethnopharmacol. 2005.
Paeonia lactiflora root ( Chinese Peony ) and Sinomenium acutum Rehder and Wilson stem are two herbs widely used in Chinese medicine to treat rheumatoid arthritis. While, in theory, either herb could be used alone, in practice, Chinese medicine practitioners prescribe them together. Studies on pharmacokinetic interaction between the active constituents of these two herbs -- peony and sinomenine, respectively -- provide empirical evidence to support their clinical practice. A single dose of paeoniflorin (150mg/kg) alone and with sinomenine hydrochloride (90mg/kg) was administered by gastric gavage to unrestrained conscious male Sprague-Dawley rats. After co-administration of sinomenine, the peak plasma concentration of paeoniflorin was elevated, the peak time was delayed, the mean residence time (MRT) was prolonged, the C(L) was decreased and the V(d) was reduced. These results indicate that sinomenine hydrochloride at 90mg/kg significantly improved the bioavailability of paeoniflorin in rats.

Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora.
Fitoterapia. 2004.
Paeoniflorin, isolated from the methanol extract of peony, showed a lowering effect on cholesterol level in the experimentally-induced hyperlipidemic rats. Paeoniflorin showed a significantly lowering effect of total cholesterol, LDL and triglyceride levels compared with the control group at the dose of 200 and 400 mg/kg, p.o. once a day for 4 weeks.

The effect of the extract from Radix Paeoniae alba ( white peony root ) on IgA Glomerulonephritis in mice
Zhong Yao Cai. 2003.
To observe the effect of the extract from Radix Paeoniae Alba ( white peony root ) on IgA glomerulonephritis in mice. METHODS: IgA glomerulonephritis was induced by injection of dextran and sephadex-150. After administrating the extract, the contents of urinary protein, BUN and Cr in serum were determined. The extract could inhibit the decline of mouse weight, and decrease urinary protein content and BUN content in serum. While, the extract had no effect on Cr in serum. The extract from Radix Paeoniae Alba had therapeutical effect on IgA glomerulonephritis. To learn more about IgA nephropathy.

Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by penta-O-galloyl-beta-D-glucose in murine macrophage cells.
Arch Pharm Res. 2003.
Activated macrophages express inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2), and produce excessive amounts of nitric oxide (NO) and prostaglandin E2 (PGE2), which play key roles in the processes of inflammation and carcinogenesis. The root of Paeonia lactiflora Pall. ( Chinese Peony ), and the root cortex of Paeonia suffruticosa Andr., are important Chinese crude drugs used in many traditional prescriptions. 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a major bioactive constituent of both crude drugs. PGG has been shown to possess potent anti-oxidant, anti-mutagenic, anti-proliferative and anti-invasive effects. In this study, we examined the inhibitory effects of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) isolated from the root of Chinese Peony. on the COX-2 and iNOS activity in LPS-activated Raw 264.7 cells, COX-1 in HEL cells. Although further studies are needed to elucidate the molecular mechanisms and structure-activity relationship by which PGG exerts its inhibitory actions, our results suggest that PGG might be a candidate for developing anti-inflammatory and cancer chemopreventive agents. Peony flower.

Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora.
Biosci Biotechnol Biochem. 2002.
Seven stilbenes, a new cis-epsilon-viniferin and the six known stilbenes, trans-resveratrol, trans-resveratrol-4'-O-beta-D-glucopyranoside, trans-epsilon-viniferin, gnetin H, and suffruticosol A and B, were isolated and identified from seeds of Chinese Peony plant.  These results suggest that resveratrol dimers and trimers, together with resveratrol from peony seeds may be useful as potential sources of natural antioxidants. Peony seed.

Cytotoxic and antimutagenic stilbenes from Peony seeds of Paeonia lactiflora.
Arch Pharm Res. 2002.
Cytotoxic and antimutagenic effects of a novel cis-epsilon-viniferin and five known stilbenes, transresveratrol, trans-epsilon-viniferin, gnetin H, suffruticosols A and B, isolated from the seeds of peony  were determined against five different cancer cell lines, and mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100, respectively. Six stilbenes showed cytotoxic activity in a dose-dependent manner, and especially did potent cytotoxic activity against C6 (mouse glioma) cancer cell with IC50 values ranging from 8.2 to 20.5 microg/ml. trans- Resveratrol showed significant cytotoxic activity against HepG2 (liver hepatoma) and HT-29 (colon) human cancer cell lines.

Additional Chinese Herbs
Rehmannia Root extract
Poria Cocos Sclerotium herb
Dioscorea Root herb
Fo Ti herb
Chrysanthemum Flower herb
Lycii Fruit Extract also known as goji berry
Cornus Fruit herb

Peony Paeonia Lactiflora supplier
I know you from internet that your company maybe in the business field of the Paeonia Lactiflora extract. I am now writing you to seek the possibilities to cooperate with your company. Our company, Ningbo Liwah Pharmaceutical Co., Ltd.is a company with about 50 years history, that it is in top 50 in Traditional Chinese Medicine manufacturing and is one of the biggest extract bases nationwide. If you need the Paeonia Lactiflora extract .please feel free with me. Paeonia Lactiflora P.E Paeonia lactiflora pall, a traditional chinese herb, has been using to be an effective component of prescriptions for many diseases. The total glucosides of peony (TGP) , a powder substance extracted from paeonia lactiflora pall root, is composed of paeoniflorin (90 %), hydroxypaeoniflorin, paeonin, and so on. The anti-inflammatory and immunoregulatory activities of TGP had been extensively proved in clinical for many years. Minister of Sales Dept Mr. Lin Jun Ningbo Liwah Pharmaceutical Co..