Phenibut is a new supplement to the health industry. Research has been conducted in Russia but little knowledge exists in Western medicine regarding its properties. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients; as well as a pre- or post-operative medication. It is also used in the therapy of disorders characterized by asthenia and depression, as well as in post-traumatic stress, stuttering and vestibular disorders.
Apparently, the limited research with phenibut indicates it has a role to play in alcohol use; has GABA like activity inducing relaxation.
Effect of phenibut on the behavior of experimental animals under conditions of voluntary chronic alcoholism
Eksp Klin Farmakol. 2005.
The effect of phenibut on the locomotor and orientation-research activity, as well as on the alcohol and food motivation, was studied on experimental animals under conditions of voluntary chronic alcoholism. Phenibut decreased the manifestations of alcohol-induced behavioral disorders and reduced alcohol motivation.
Effect of the GABA derivative phenibut on learning
Vestn Ross Akad Med Nauk. 2005.
The learning effect of phenibut, a beta-phenyl derivative of the inhibitory neuromediator GABA, used in a subcutaneous dose of 40 mg/kg 2 hours before each experiment, was studied in rabbits. The injection of phenibut was shown to enhance not only the inhibitory, but also excitatory components of cerebral cortical neuronal responses to all applied stimuli. The findings support the concept that the GABAergic neuromediator system is involved in the elaboration of internal inhibition and explain the sense of intracerebral processes that ensure both the sedative properties of phenibut and its ability to improve patients' systemic tone and health status when brain dysfunctions are treated.
Cardiac effects of fenibut in development of experimental
chronic renal insufficiency
Eksp Klin Farmakol. 2003.
St. Petersburg State Medical University, St. Petersburg, Russia.
The effect of fenibut on the mechanical activity of myocardium was studied in vitro and in vivo in rats with experimental chronic renal insufficiency (CRI) in a regime of physiologically alternating load simulating the intact heart function. The administration of fenibut (10 mg/kg) in rats after nephrectomy prevents the development of myocardial hyperfunction (characteristic of the animals with CRI in stage 1). In in vitro experiments on isolated myocardium fenibut also decreased the myocardial hyperfunction and reduced contractility to a control level, which was accompanied by accelerated relaxation in all finite systolic lengths.
Anti-arrhythmic properties of GABA and GABA-ergic system
Eksp Klin Farmakol. 2002.
Clinical and experimental data available in the literature are summarized, which are indicative of the antiarrhythmogenic properties of GABA and substances possessing GABA-positive activity (phenibut, piracetam, sodium hydroxybutyrate, lithium hydroxybutyrate, etc.). The antiarrhythmic effects are manifested in various cases of the heart rhythm violation. The mechanism of this action is related to activation of the central and peripheral retarding GABAergic system, as well as to antihypoxant, antioxidant, and antistressor effects.
Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.
CNS Drug Rev. 2001.
Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects.
Q. Great Site! Kudos to the Doctor. I encourage you to include info on Phenibut, a modified version of GABA that crosses the blood brain barrier. I find it VERY effective to reduce generalized anxiety disorder for short term use. The most effective anxiety reducer of any non-Benzo I've tried.
Q. Glad to see you've now added a profile for Phenibut.
I wanted to give my experiences with this medicine in the hope that it might
help anyone out there wondering how well it works. I suffer from generalized
anxiety disorder and I must say phenibut at a high dose of 2 grams absolutely
kills the anxiety. Lower doses have smaller effects. The effects make themself
apparent at 1-2 hours after oral dosing and last for perhaps 4-5 hours. It does
a good job at reducing anxiety, it is however a SHORT TERM solution only.
Tolerance seems to develop within days with continuous dosing (which takes about
2 weeks of complete abstinence from Phenibut to disappear) and it is therefore
best to use sparingly, perhaps once a week during particularly bad episodes of
anxiety. This kind of frequency of use does not seem to develop tolerance. At
the relatively high dose of 2g it does make me drowsy and nauseous after
approximately 4-5 hours. A hangover and some rebound anxiety is expected the
next day, leaving me to question the point of this drug. It's a shame because
its anxiolytic effects are absolutely fantastic, but the hangover, rebound
anxiety and nauseous feeling seem to leave you feeling pretty bad the day after.
I've been reading up on phenibut since it appeared on the market and the above
experience seems to echo what a lot of people are describing (in terms of
hangover, rebound anxiety, tolerance) so they aren't side-effects isolated to me
only. People are using anywhere from 250mg - 2,000mg to induce an anxiolytic
A. Thank you so much for sharing this experience with us.
I see that you've got a page up detailing Phenibut, the Russian nootropic and anxiolytic. I have been using it on and off for along time now, with varied effects, and to the extent at one point that withdrawal was a very miserable experience. Everyone is different and while it's great for me for anxiety, if I'm not able to taper off of it the withdrawal is pretty bad for me, so it might be nice to caution everyone about it. I'm not alone, there are people who took far more and for far longer than me and many have ended up in addiction treatment scenarios similar to those who are addicted to many other forms of benzodiazepines. The real word of caution, though, should be about supplement quality. When I was using it frequently enough to feel withdrawal when I didn't use it, I noticed that between brands there was a huge variability in the true strength of the phenibut. Some gave me tics, mostly in my face and back, but some was not this way at all. Some also was definitely cut with something inert, because I could take twice my normal dose and not feel any effect; in fact it was just enough to keep withdrawal symptoms at bay in some cases. Another time, a new bottle of capsules arrived and not realizing it I took on 750mg dose (I use it pretty sparingly due to my sensitivity), and that combined with the fact that this stuff must've been really pure or uncut meant that I was really sedated and although it was enjoyable, it was unintentional and I'm glad I wasn't headed out for a drive or anything that required all of my reaction times and faculties. Anyway, I hope that helps.