Phenylethylamine PEA by
Ray Sahelian, M.D.
January 20 2017
Phenylethylamine is now available as a raw material ingredient. Phenylethylamine is an alkaloid and monoamine.
Function of phenylethylamine
In the human brain, phenylethylamine may work as a neurotransmitter. Phenethylamine is a natural compound made from the amino acid phenylalanine.
Webmedcentral. 2013. β-phenylethylamine, a small molecule with a large impact. During a screen of bacterial nutrients as inhibitors of Escherichia coli O157:H7 biofilm, the Prüß research team made an intriguing observation: among 95 carbon and 95 nitrogen sources tested, β-phenylethylamine (PEA) performed best at reducing bacterial cell counts and biofilm amounts, when supplemented to liquid beef broth medium. This review article summarizes what is known about PEA. After some starting information on the chemistry of the molecule, we focus on PEA as a neurotransmitter and then move on to its role in food processing. PEA is a trace amine whose molecular mechanism of action differs from biogenic amines, such as serotonin or dopamine. Especially low or high concentrations of PEA may be associated with specific psychological disorders. For those disorders that are characterized by low PEA levels (e.g. attention deficit hyperactivity disorder), PEA has been suggested as a 'safe' alternative to drugs, such as amphetamine or methylphenidate, which are accompanied by many undesirable side effects. On the food processing end, PEA can be detected in food either as a result of microbial metabolism or thermal processing. PEA's presence in food can be used as an indicator of bacterial contamination.
Phenylethylamine and MAO
Concentrations of phenylethylamine PEA are greatly increased in brain following administration of monoamine oxidase inhibitor antidepressants. Phenylethylamine is a metabolite of the MAOI antidepressant phenelzine.
Some individuals who crave chocolate in large amounts tend to do so when they feel emotionally unfulfilled. There have been a series of articles in lay magazines that chocolate's mood elevating properties reflect 'drug-like' substances such as anandamines, caffeine, phenylethylamine and magnesium. However, the levels of these substances are so low as to preclude such influences. As all palatable foods stimulate endorphin release in the brain this is the most likely mechanism to account for the temporary elevation of mood from chocolate consumption. Phenylethylamine is found in many foods such as chocolate, especially after microbial fermentation. It has been suggested that phenethylamine from food may have psychoactive effects in sufficient quantities. However, it is quickly metabolized by the enzyme MAO-B, preventing significant concentrations from reaching the brain.
I have been to South Africa and tested kanna extract. That would bee something for you. Do you any vendor of 2 phenylethylamine.
We are not familiar with kanna extract.
Am J Drug Alcohol Abuse. 2015. Characteristics of novel psychoactive substance exposures reported to New York City Poison Center, 2011-2014. Novel psychoactive substances (NPS) are emerging at an unprecedented rate. Likewise, prevalence of use and poisonings has increased in recent years. Prevalence of NPS exposures was 7% in 2011, rising to 12% in 2014. Most exposures (82%) involved SCRA use. The second and third most prevalent classes were phenethylamines/synthetic cathinones ("bath salts"; 10%) and psychedelic phenethylamines (4%).