Pinoresinol is a lignan found in plants
February 1 2017

Fungal infection
 Molecules. 2011. Antifungal effect of pinoresinol isolated from Sambucus williamsii. School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Puk-ku, Daegu, Korea.
In this study, we investigated the antifungal activity and mechanism of action of pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii, used in traditional medicine. Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis indicated that pinoresinol caused damage to the fungal plasma membrane. The present study indicates that pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

J Agric Food Chem. 2008. Lignans and other constituents of the fruits of Euterpe oleracea Acai Berry with antioxidant and cytoprotective activities. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA. Using a hydroxyl radical scavenging assay, bioactivity-guided fractionation of a methanol-soluble extract of the fruits of Euterpe oleracea (acai) led to the isolation of 22 compounds of previously known structure. Altogether, 14 of these isolates were found to be active. Dihydroconiferyl alcohol, lariciresinol, pinoresinol, syringaresinol, and protocatechuic acid methyl ester exhibited cytoprotective activity in cultured MCF-7 cells stressed by H2O2. Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types.

Appl Environ Microbiol. 2014.Bioconversion of pinoresinol into matairesinol using recombinant Escherichia coli. Lignans, a class of dimeric phenylpropanoid derivative found in plants, such as whole-grain and sesame and flax seeds, have anticancer activity and can act as phytoestrogens. The lignans secoisolariciresinol and matairesinol can, respectively, be converted in the mammalian proximal colon into enterolactone and enterodiol, which reduce the risk of breast and colon cancer.