Platycodin information and review
February 1 2017

Platycodin D is a major constituent of triterpene saponins found in the root of Platycodon grandiflorum

Cancer prevention
Platycodin D may have anti-cancer potential.

Human studies
As of 2016, we have not seen any human studies with this substance.

Platycodin immune effect
Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen.
Vaccine. 2009. Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture, Zhejiang University, Hangzhou, Zheijiang, China; School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.
The ideal adjuvants for hepatitis B vaccines should be capable of eliciting both strong humoral and cellular immune responses, especially Th1 cell and cytotoxic T lymphocyte (CTL) responses. However, Alum used as adjuvants in the hepatitis B vaccines currently commercialized offers limitation in inducing cell-mediated response. Therefore, a less hemolytic saponin platycodin D from the root of Platycodon grandiflorum has been explored for its potential as an alternative adjuvant. Our results indicate that platycodin D has strong potential to increase both cellular and humoral immune responses and elicit a balanced Th1/Th2 response against HBsAg, and that platycodin D may be the candidates as adjuvants for use in prophylactic and therapeutic hepatitis B vaccine.

Platycodin research studies, cholesterol lowering
Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice.
Eur J Pharmacol. 2006. Natural Products Research Institute, Seoul National University, Seoul, Republic of Korea.
This study investigates the in vivo hypocholesterolemic action of platycodin D and its in vitro evidence for the cholesterol-lowering properties. In order to examine the effects of platycodin D on hypercholesterolemia in male ICR mice, platycodin D with doses of 15, 30 or 50 mg/kg was orally administered for 8 weeks. Both in vivo and in vitro results demonstrate a potential value of platycodin D as a novel cholesterol-lowering and anti-atherogenic candidate.
    Other nutritional supplement products to consider for cholesterol are beta sitosterol, psyllium, fish oils, and pectin.