Polyposis natural remedy by Ray Sahelian, M.D.
Familial adenomatous polyposis is an autosomal dominant disorder leading to the development of hundreds of colorectal adenomas and eventual colorectal cancer. These colonic polyposis usually show no symptoms.
Treatment for familial adenomatous polyposis
Regression of adenomas in this syndrome occurs
with the administration of nonsteroidal anti-inflammatory drugs and
cyclooxygenase-2 inhibitors, but these compounds can have considerable side
effects. Natural treatment options with curcumin, quercetin and other natural
supplements are just being evaluated.
Natural and alternative therapy
It is exiting to discover that natural supplements could be helpful in the
treatment of familial adenomatous polyposis.
Curcumin and quercetin for Familial adenomatous
polyposis
Combination treatment with curcumin and quercetin of
adenomas in familial adenomatous polyposis.
Clin Gastroenterol Hepatol. 2006 August. Cruz-Correa M, et al.
Department of Medicine, Cleveland Clinic, Weston, Florida, USA.
We evaluated the efficacy of the combination of diet-derived nonprescription
supplements curcumin and quercetin to regress adenomas in patients with familial
adenomatous polyposis. Five familial adenomatous polyposis patients with prior
colectomy (4 with retained rectum and 1 with an ileal anal pouch) received
curcumin 480 mg and quercetin 20 mg orally 3 times a day. The number and size of
polyps were assessed at baseline and after therapy. All 5 patients had a
decreased polyp number and size from baseline after a mean of 6 months of
treatment with curcumin and quercetin. The mean percent decrease in the number
and size of polyps from baseline was 60 and 50, respectively. Minimal adverse
side effects and no laboratory abnormalities were noted. The combination of
curcumin and quercetin appears to reduce the number and size of ileal and rectal
adenomas in patients with familial adenomatous polyposis without appreciable
toxicity.
Fish oils and omega-3 fatty acids
The omega-3 polyunsaturated fatty acid
eicosapentaenoic
acid (EPA) has anticolorectal cancer activity in vitro and in preclinical
models. The present study tested whether a novel, enteric-coated formulation of
EPA, as the free fatty acid (EPA-FFA), has chemopreventative efficacy in
patients with familial adenomatous polyposis (FAP), in a randomised,
double-blind, placebo-controlled trial. Patients undergoing endoscopic
surveillance of their retained rectum postcolectomy were randomised to EPA-FFA
(SLA Pharma) 2 g daily or placebo for 6 months. EPA-FFA has chemopreventative
efficacy in FAP, to a degree similar to that previously observed with selective
cyclo-oxygenase-2 inhibitors. EPA holds promise as a colorectal cancer
chemoprevention agent with a favorable safety profile. West NJ, Clark SK,
Phillips RK, Hutchinson JM, Leicester RJ, Belluzzi A, Hull MA. Section of
Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James's
University Hospital, Leeds, UK. Gut. 2010 July.
Familial polyposis symptom
Symptoms of familiar colonic polyposis are infrequent but could include rectal
bleeding, abdominal pain, and diarrhea.
Other types of polyposis
Nasal polyposis
Hamartomatous intestinal polyposis
Gastric polyposis
Juvenile polyposis