Prader-Willi syndrome is characterized by hypothalamic dysfunction resulting in obesity, hypotonia, hypogonadism, and behavioral abnormalities. Clinical features of Prader-Willi syndrome resemble those of growth hormone deficiency (decreased total lean body mass, IGF-I levels, and poor linear growth). Marked reductions in muscle mass are associated with diminished strength, physical function, and energy expenditure. Lifelong morbidities of Prader-Willi syndrome include osteoporosis, type 2 diabetes mellitus, respiratory disorders, and cardiorespiratory failure related to obesity and hypotonia.

HGH and Prader-Willi Symdrome
HGH helps hundreds of children with a rare disorder that causes them to gorge on food, but for some, starting HGH treatment can worsen a dangerous nighttime breathing problem. Sleep apnea disrupts breathing during sleep and is common among morbidly obese children, including those with Prader-Willi syndrome, a disease that compels them to eat nonstop. Researchers say that uncovering how to treat obesity and related problems in children genetically wired to be overweight could help them better battle childhood obesity in general. HGH has shown to be one of the most effective ways to treat children and adults with Prader-Willi. But researchers found that starting HGH treatment can worsen or trigger sleep apnea in obese children exposed to colds, potentially leading to death. Source: The Journal of Clinical Endocrinology and Metabolism, Jan 2006.

Emails regarding Prader-Willi Syndrome
Q. My son William was born on July 31, 2001 with Prader-Willi Syndrome. At the age of 3 months William was still sleeping 20 plus hours a day had no normal wake / sleep pattern when I found information regarding Prader-Willi Syndrome and the benefits of coenzyme q10. I immediately ordered coenzyme q10 and began giving William 90 mg daily he almost immediately responded with a normal wake / sleep pattern. Have you done any research with coenzyme q10 and Prader-Willi Syndrome? I'm very interested in any research information you may have.
   A. We have not evaluated this condition in relation to coenzyme q10, however we will mention it on our website and maybe others with this condition may try it, with their doctor's supervision, and give us feedback.