Prolactin level hormone side effects and benefit by Ray Sahelian, M.D.
Feb 15 2014

 

Prolactin is a pituitary hormone that plays a pivotal role in a variety of reproductive functions. If you are interested in the latest research on natural supplements and hormones, consider subscribing to a free natural medicine newsletter sent by email.

 

Influence on metabolism

Prolactin affects metabolic homeostasis by regulating key enzymes and transporters that are associated with glucose and lipid metabolism in several target organs. In the lactating mammary gland, prolactin increases the production of milk proteins, lactose and lipids. In adipose tissue, it generally suppresses lipid storage and adipokine release. Prolactin  supports the growth of pancreatic islets, stimulates insulin secretion and increases citrate production in the prostate. A specific case is made for prolactin in the human breast and adipose tissue, where it acts as a circulating hormone and an autocrine or paracrine factor. Although the overall effects of prolactin on body composition are modest and species specific, prolactin might be involved in the manifestation of insulin resistance.

 

High prolactin Level

Hyperprolactinemia is a common condition that can result from a number of causes; including use of medications and hypothyroidism, as well as pituitary disorders. Depending on the cause and consequences of hyperprolactinemia, selected patients require specific treatment. The underlying cause of hyperprolactinemia, sex, age and reproductive status must be considered. Management of this condition depends heavily on the cause and on the effects it has on the patient. The definition of the hyperprolactinemia is not uniformed, and in various clinical settings various criteria of this status are used. In the identification of hyperprolactinemia not only simple measurements of the prolactin serum level are used, the dynamic tests with the use of dopamine antagonists have a special role as well. Neither the measurement of the serum prolactin level, nor dynamic tests with dopamine antagonists are able to determine the presence of macroprolactin molecules in the serum, and this can lead clinicians to establish the false diagnosis of hyperprolactinemia.
   One cause of a high prolactin level, particularly in women, is treatment with Prozac or other SSRI drugs.

 

Prolactin and Multiple sclerosis
MS can go into remission when women are pregnant. A study involving mice showed that prolactin triggers production of myelin, a fatty substance that insulates nerve cells in the brain and spinal cord. In multiple sclerosis, the immune system, which normally protects the body, is believed to attack the myelin that coats nerve cells, causing a worsening loss of sensation and movement that can range from relatively minor to profoundly disabling. Perhaps future research will find prolactin could be used in people to repair damage caused by MS and improve their symptoms. Prolactin increases in the body during pregnancy and is involved in stimulating milk production among other things.
 

Prolactin as one of the reproductive hormones

The three reproductive hormones (leutinizing hormone, follicle-stimulating hormone, prolactin). Reproductive hormones are probably the most commonly measured hormones after the thyroid hormones.

 

Human reproductive evolution, involving a complex interaction of the hypothalamic-pituitary-ovarian axis, the release of pulsatile and threshold concentrations of gonadotrophins and positive and negative feedback systems, has ensured the release of a single viable egg and functioning corpora lutea in the natural menstrual cycle.

 

Antipsychotic medications
Schizophr Res Treatment. 2013. Effects of Antipsychotics on Prolactin Levels and Women's Menstruation. Typical and atypical antipsychotic agent is currently used for treatment in the majority of patients with psychotic disorders. The aim of this review is to assess antipsychotic induced hyperprolactinaemia and the following menstrual dysfunction that affects fertility, quality of life, and therapeutic compliance of women. Method. For this purpose, Medline, PsychInfo, Cochrane library, and Scopus databases were accessed, with a focus on the publication dates between 1954 and 2012. Research of references was also performed and 78 studies were retrieved and used for the needs of this review. Results. A summary of several antipsychotics as well as frequency rates and data on hyperprolactinaemia and menstrual disorders for different agent is presented. Conclusion. Diverse prevalence rates of hyperprolactinaemia and menstrual abnormalities have been found about each medication among different studies. Menstruation plays an important role for women, thus, understanding, careful assessment, and management of hyperprolactinaemia could enhance their lives, especially when dealing with women that suffer from a psychotic disorder.

 

Questions
Do you sell a tested herbal product for suppressing prolactin?
   I am not aware of an herb or such a natural product specifically tested for prolactin suppression.
 

Does the supplement LJ100 influence prolactin?
   LJ100, an extract of tongkat ali, may influence hormone levels but it is not clear what kind of influence it has.
 

Wondering if you have any products for prolactinoma patients.
   At this time we don't have any natural herbs or products for prolactinoma patients.

 

I would like to know if you have any natural products that could help with increasing my dopamine levels as I have a prolactinoma and would like to reduce the level of prolactin in my body. As a result of my prolactinoma I suffer from mood changes , depression, low libido, and a lot of pigmentation on my face, are there herbs that could help with the pigmentation? I have been taking chaste berry for some years, with minimal improvement. I am very much against the medications that the endocrinoligists suggested, I tried them and I kept vomiting and had bad headaches, and do not want to take these drugs for the rest of my life.
    You can review this page on dopamine, but I am not aware of any supplements or herbs that treat this condition.

 

Is l-dopa effective for lowering prolactin levels? Do you have any recommendations for folks with elevated levels? I currently take B6 (P5P) and zinc. I have idiopathic hyperprolactinemia; there is no tumor present on pituitary MRI so docs don't know why prolactin is elevated.

 

I am wondering if you know information associated with prolactinoma patients taking aphanizomenon flos-aquuae and it being a success?
   This is outside my range of knowledge.