Protandim information by Ray Sahelian, M.D.

Protandim is a trademarked product that has five herbs with antioxidant properties. Lifeline Therpeutics claims the following about Protandim:

Protandim is a patent-pending dietary supplement that increases the body's natural antioxidant protection by inducing two protective enzymes, superoxide dismustase (SOD) and catalase (CAT). These naturally occurring enzymes simply become overwhelmed by free radicals as we get older. Oxidative stress (cell damage caused by free radicals) occurs as a person ages, when subjected to environmental stresses or as an associated factor in certain illnesses. TBARS are laboratory markers for oxidative stress in the body. New data from a scientific study in men and women show that after 30 days of taking Protandim, the level of circulating TBARS decreased an average of 40 percent, with this decrease shown to be maintained at 120 days. Protandim strengthens a person's defenses against oxidative stress by increasing the body's natural antioxidant enzymes.

Protandim(R) study results
Lifeline Therapeutics, Inc. has announced data from a human study published in the scientific journal, Free Radical Biology & Medicine (Jan. 15, 2006), that demonstrated Protandim (R) was able to reduce oxidative stress in men and women. Oxidative stress results when the balance between oxidants and antioxidant enzymes is upset. The study measured the levels of TBARS (thiobarbituric acid-reactive substances), harmful substances created when cells are damaged by oxidation, in 29 subjects. People taking Protandim (R) experienced reduced oxidative stress, as demonstrated by reducing the amount of TBARS circulating in the blood by an average of 40 percent. This reduced oxidative stress occurred as a result of significantly increasing the activity of antioxidant enzymes that naturally help regulate healthy oxidative balance. In this study, before starting Protandim, study participants, who ranged in age from 20 to 78, showed a strong age-related increase in TBARS. After 30 days of taking Protandim (R), a 40 percent average decrease in TBARS was seen, and the age-related increase was eliminated. By 120 days of supplementation, Protandim (R) also significantly increased activity of superoxide dismutase and catalase antioxidant enzymes by 30 percent and 54 percent, respectively.

Ingredients in Protandim
Ashwagandha is an Ayurvedic herb
Bacopa also has some mind enhancing properties
Curcumin is an extract from turmeric. For more curcumin turmeric research information.
Green tea herb
Milk thistle herb

Protandim emails
ABC Prime Time had an episode in June, 2005 promoting the five herbs in Protandim as excellent antioxidants. We had an email about this:

Q. What do you think about this pill Protandim that they say may slow the aging process by increasing antioxidant enzymes that fight free radicals? I saw it on Primetime the other night!
   A. Protandim consists of 5 common herbal extracts: Ashwagandha, Bacopa, Curcumin, Green tea, and Milk thistle. These are all excellent herbs and one can buy them in this combination or take them separately. There are countless herbs that have potent antioxidant properties, not just these five. Others that come to mind include goji berry, acai berry, pomegranate, noni, basil, thyme, oregano, and countless others.

Q. Can I take Protandim the same day as saw palmetto and 5-htp?
   A. Probably. Protandim can be taken with breakfast along with saw palmetto, and 5-HTP can be taken in the evening one to three hours before bed.

Lifeline Therapeutics Income and Loss

DENVER, Aug 22, 2006 (BUSINESS WIRE) -- Lifeline Therapeutics, Inc. (LFLT) , maker of Protandim, today announced preliminary results for its fiscal year ended June 30, 2006. The company recorded net revenues of $7.2 million and a loss of $(2.7) million, or $(0.12) per share, for its fiscal year ended June 30, 2006. For its fiscal year ended June 30, 2005, revenues were $2.4 million and a loss of $(5.8) million, or $(0.33) per share. Stephen K. Onody, CEO of Lifeline Therapeutics, commented: "Fiscal Year 2006 was a transition year for Lifeline Therapeutics. While we are pleased with the over 200% increase in revenue from our 2005 fiscal year, attributable to our first full year of shipment of Protandim, our operating results are not satisfactory. Our management changes and initiatives in distribution, advertising, and messaging are focused on sales growth and customer service, as reflected in the fourth quarter increase in operating expense in those areas.