Pterostilbene antioxidant by Ray Sahelian, M.D.
Feb 14 2014

Pterostilbene is similar to the antioxidant resveratrol found in grapes and red wine, which also has anticancer activity. It is also present in grapes, but it is more abundant in blueberries. In the test tube and in animals pterostilbene is capable of lowering cholesterol levels.

J Surg Res. 2012. Pterostilbene and cancer: current review. Trans-3,5-dimethoxy-4-hydroxystilbene is an antioxidant that is primarily found in blueberries. Studies suggest that it exhibits the hallmark characteristics of an effective anticancer agent based on its antineoplastic properties in several common malignancies. In vitro models have shown that pterostilbene inhibits cancer growth through alteration of the cell cycle, induction of apoptosis, and inhibition of metastasis. In vivo, pterostilbene inhibits tumorigenesis and metastasis with negligible toxicity. Pterostilbene has also been shown to be effective as an inducer of antioxidant capacity in multiple cancer cell lines that may facilitate its function as an anticarcinogenic compound. Additionally, preliminary studies show that pterostilbene exhibits much greater bioavailability compared with other stilbene compounds; however the exact pharmacologic mechanism of pterostilbene and its effects in humans are still under investigation. In this review, we present a comprehensive summary of the antineoplastic mechanisms of pterostilbene based on the results of preclinical studies and highlight recent advances in the study of this dietary compound.

Pterostilbene and colon cancer
A natural antioxidant abundant in blueberries called pterostilbene may help prevent colon cancer. Dr. Bandaru S. Reddy, chemical biologist at Rutgers University, Piscataway, New Jersey, induced colon cancer in 18 rats and then fed the animals a balanced diet, with or without pterostilbene (40 mg/kg of diet). At the end of the study, the nine animals that received pterostilbene supplement had 57-percent fewer pre-cancerous growths in the colon compared with the animals that were fed a balanced diet only. Pterostilbene also suppressed the growth of cells in the colon and inhibited certain genes involved in inflammation, both of which are considered risk factors for colon cancer.

Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats.
Clin Cancer Res. 2007 .Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Laboratory animal model studies have provided evidence that stilbenes, phenolic compounds present in grapes and blueberries, play a role in inhibiting the risk of certain cancers. Pterostilbene, a naturally occurring stilbene from blueberries, was tested for its preventive activity against colon carcinogenesis. Experiments were designed to study the inhibitory effect of pterostilbene against the formation of azoxymethane-induced colonic aberrant crypt foci (ACF) preneoplastic lesions in male F344 rats. The results of the study suggest that pterostilbene, a compound present in blueberries, is of great interest for the prevention of colon cancer.

Pterostilbene as antioxidant
The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats.
J Pharm Pharmacol. 2006.
The antioxidant effect of pterostilbene on streptozotocin-nicotinamide-induced diabetic rats has been assessed. The activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione was significantly decreased in liver and kidney of diabetic animals when compared with normal control. There were significant improvements in these activities after treatment with pterostilbene at a dose of 40 mg kg(-1) for six weeks. The increased levels of lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) in liver and kidney of diabetic rats were also normalized by treatment with pterostilbene. Chronic treatment of pterostilbene remarkably reduced the pathological changes observed in liver and kidney of diabetic rats. These results indicated the antioxidant property of pterostilbene.

Questions
I read somewhere about an ayurvedic herb having pterostilbene in it. I think it is called darakchasava, if i am not mistaken.
   Darakchasava is an Indian herbal preparation of which the main ingredient is Vitis vinifera L. This ayurvedic medicine is prescribed as a cardiotonic and to maintain healthy blood sugar, and contains polyphenols like resveratrol and pterostilbene.

What is Pterinol?
pTerinol is a trademarked product that contains pterostilbene. pTerinol has 25% pterostilbene from Malabar Kino bark. pTerinol is a trademarked product of Lobsons International.

I received an information email about this substance. This LIVE webinar, on Tuesday, September 28th will focus on pterostilbene, a natural derivative of resveratrol found in small berries such as blueberries and grapes. Like resveratrol, pterostilbene functions as an antioxidant and an anti-aging agent. It has been shown to help lower cholesterol and blood glucose levels. Unlike resveratrol, it has greatly improved oral adsorption and metabolizes more slowly in the body, allowing more time for its antioxidant activities to take place. What you will learn about pterostilbene from this webinar. Dr. Agnes Rimando* Learn how pterostilbene functions as a neuroprotecting agent and thus acts as a potential cognitive function enhancer.* Discover the anti-oxidant potential and how it acts to protect cells from oxidative stress. Dr. Dennis Feller* Learn about the role of pterostilbene as a PPAR-alpha agonist in the lowering of cholesterol. Dr. Jeremy Bartos* Grasp the similarities and differences between pterostilbene and resveratrol and why the former has a higher biopotential and bioavailability than resveratrol* Receive a brief overview of recently published science supporting the benefits from heart health and anti-aging to diabetes and cancer. The presentation will also explain the science behind pterostilbene’s ability to lower cholesterol and how it acts to reduce oxidative stress and promote anti-aging. “Pterostilbene has the potential to be one of the most significant new ingredients the dietary supplement field has seen in a long time," said Frank L. Jaksch Jr., cofounder and CEO of ChromaDex. “The science behind the use of pterostilbene as an alternative to resveratrol is sound. To further demonstrate the benefits, ChromaDex is sponsoring, in collaboration with the University of Mississippi, the first human clinical study.”
   I think it is premature to make all these claims without proper long term human studies.