Prostate Power Rx formulated by Ray Sahelian, M.D.
Passion Rx for men with libido problems

Pygeum africanum is a large evergreen tree found in central and southern Africa. The extracts from the pygeum bark contain several compounds thought to be helpful in prostate health. Pygeum extracts have been used for more than 40 years in France, Germany, and Austria for patients suffering with prostate enlargement. Benign prostatic hyperplasia (BPH), a nonmalignant enlargement of the prostate that occurs in most men over 60, can lead to urinary frequency and nocturia (waking up at night to go to the bathroom). Frequent interruption of sleep leads to daytime tiredness. The pharmacologic use of plants and herbs for the treatment of BPH has been growing steadily and a well-known herb used for this purpose is saw palmetto. The extract of the African prune tree, pygeum africanum, is one of several herbal agents used by many men who have BPH.

What's in Pygeum africanum bark?
The extracts from pygeum bark include beta-sitosterol, other plant estrogens, triterpenes, and certain compounds known as ferulic acids.

Pygeum herb, Nature's Way
Nature's Way Pygeum (Pygeum africanum) extract is a specialized formula designed to promote prostate health. This unique combination contains a leading European Pygeum extract combined with synergistic nutrients in a base of Pumpkin seed oil.

Supplement Facts:
Pygeum africanum dried extract
Vitamin B6
Zinc (as Zinc citrate)
Selenium
Copper (as Copper citrate)
Lecithin


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Subscribe to a FREE Supplement Research Update newsletter. Twice a month you will receive an email with a review of several new studies on various supplements and natural medicine topics and their practical interpretation by Ray Sahelian, M.D. We will mention research updates on pygeum and prostate health.

Recommendation: Take one or two pygeum africanum softgels two times daily with water at mealtimes. Best results are obtained with continuous use.

* Pygeum africanum daily value not established.

Pygeum dosage
The recommended dose of pygeum is 50 to 150 mg daily. One study shows that the dosing frequency is not crucial. Pygeum africanum extract at 50 mg twice daily and 100 mg once daily proved equally effective and safe. It appears that pygeum remains effective with long term use.

Prostate Power Rx with Pygeum Africanum
Formulated by Ray Sahelian, M.D.

With Saw Palmetto, Pygeum, Stinging Nettle, Quercetin, & 9 Key Ingredients for support of normal prostate size & urine flow

Prostate Power Rx with pygeum is carefully formulated with important herbs and nutrients to provide optimal prostate health. Significant clinical research on prostate enlargement has been conducted with the potent herbs in Prostate Power Rx. This prostate formula has been designed to support:

Saw Palmetto extract standardized to contain 45% fatty acids - serenoa repens fruit
Stinging Nettle 4:1 extract (urtica diocia root)
Quercetin (one study shows the combination of quercetin and finasteride works very well)
Rosemary 4:1 extract (Rosemarinus officinales leaf)
Beta-Sitosterol extract
Pygeum 4:1 bark extract (Pygeum Africanum)
Daidzein (standardized to contain 40% isoflavones)
   (treatment with the isoflavones daidzein and genistein, the estrogen-like compounds found in soy, block prostate growth in rats)
Genistein (standardized to contain 40% isoflavones)
Lycopene (Lycoperscion escatatum fruit)

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PAassion Rx  Medical Doctor formulated for optimal sexual health
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How quickly does Passion Rx work?
Passion Rx provides results that are often seen within 1 to 4 hours, but continue to improve the next day, and over several days of use. Our feedback thus far indicates more than 85% user satisfaction.

 

Passion Rx supports and enhances healthy:

•      Libido and sexual thoughts
•      Erectile function
•      Orgasms and climaxes
•      Energy and stamina 

In recent years science has made breakthroughs in the understanding of sexual dysfunction. But, for hundreds of years, civilizations around the world have known about locally grown herbs that achieve wonderful results with far fewer side effects than prescription drugs.
     Now, renowned physician and herbal expert Dr. Ray Sahelian, M.D., author of Natural Sex Boosters, has discovered a combination of exotic herbs from the Amazon jungle, India, China, Malaysia, and Africa, that support healthy desire and performance, as well as to simply enhance sexual pleasure. Passion Rx provides a natural solution for those looking for an alternative to synthetic drugs.

The potent herbal extracts in Passion Rx include Ashwagandha, Aspallum purificata, Catuaba, Cnidium, Coleus forskohlii, Damiana, Horny-Goat-Weed, Maca, Mucuna pruriens, Muira puama, Passion flower, Pfaffia paniculata, Rehmannia, Rhodiola, Tongkat-Ali and Tribulus.


Pygeum africanum availability
Pygeum is sold by herbal suppliers either as pygeum powder of as an extract. As an extract, pygeum bark is available in various potencies including 15 percent sitosterols.

Pygeum Research Review
To investigate whether extracts of pygeum are more effective than placebo in the treatment of BPH, statisticians at the Center for Chronic Disease Outcomes in Minneapolis, Minnesota searched all published studies from 1966 to 2000. A total of 18 randomized controlled trials involving 1562 men were analyzed. Compared to men receiving placebo, men using pygeum were more than twice as likely to report an improvement in symptoms. Nocturia was reduced 20 percent. Adverse effects due to pygeum were mild and comparable to placebo. The statisticians conclude that pygeum africanum may be a useful treatment option for men with lower urinary symptoms due to BPH.
       
Pygeum summary
Dr. Sahelian says: Men with benign prostate enlargement who have not benefited by saw palmetto alone may consider discussing with their health care professional regarding the addition of pygeum. A review of published research on Medline in December of 2007 did not show any recent human studies with pygeum supplement.

Pygeum Research Update
Low-dose Pygeum protects the rabbit bladder from bilateral ischemia/ reperfusion-induced contractile dysfunction.
Phytomedicine. 2005 Jan;12(1-2):17-24.
Recent studies indicate that focal ischemia/reperfusion (I/R) can cause the contractile dysfunctions induced in animal models of partial bladder outlet obstruction. Pygeum (Pygeum africanum) pretreatment can prevent the rabbit bladder from developing the contractile and biochemical dysfunctions induced by partial outlet obstruction, possibly by protecting the bladder from ischemic injury. The current study was designed to determine whether pre-treating rabbits with a clinically relevant dose of Pygeum could prevent the bladder from developing the contractile dysfunctions that are induced by bilateral ischemia followed by reperfusion. New Zealand White rabbits were separated into two groups. One group was pre-treated by oral gavage for 3 weeks with Pygeum (3.0 mg/kg body wt./ day). The second group was treated with vehicle (peanut oil). Five rabbits from each group were subjected to either bilateral ischemia for 1 or 3 h and than reperfused for either 1 h or 1 week. Five rabbits from each group were subjected to sham surgery and run with each of the experimental groups. The results of the current study show that Pygeum pretreatment at the clinically relevant dose of 3.0 mg/kg body wt./day protected the bladder from the contractile dysfunctions induced by bilateral ischemia followed by reperfusion. These data are consistent with the assertion that Pygeum therapy in both rabbits and humans acts by protecting the bladder smooth muscle against cellular damage caused by ischemia and reperfusion.

Antimitogenic effect of Pygeum africanum extracts on human prostatic cancer cell lines and explants from benign prostatic hyperplasia
Arch Esp Urol. 2003 May;56(4):369-78.
To analyze the effect of Pygeum africanum extracts on the in vitro proliferation of human prostate cells. Prostate cancer cell lines and benign prostatic hyperplasia derived epithelial cells were cultured and treated with Pygeum africanum extracts. The incubation with Pygeum africanum extracts, with or without addition of amino acids, significantly and in a dose-dependent manner inhibits the proliferation of prostate cancer derived cells. Pygeum africanum extracts counteracted the mitogenic action of EGF and blockrd the transition from G1 to S in the cell cycle. Pygeum africanum extracts also exerted a potent antimitogenic action on the epithelial cells derived from benign prostatic hyperplasia explants. The ethanolic Pygeum africanum extracts have an antimitogenic effect on prostate cancer cells and benign prostatic hyperplasia epithelial cells. Such effect is associated with the inhibition of the mitogenic action of pygeum, and it is accompanied by a decrease of cells entering the S Phase of the cell cycle.

Pygeum africanum for benign prostatic hyperplasia.
Wilt T, Ishani A, Mac Donald R, Rutks I, Stark G.
Cochrane Database Syst Rev 2002;(1):CD001044.
Reviewer's Conclusion: A standardized preparation of Pygeum africanum may be a useful treatment option for men with lower urinary symptoms consistent with benign prostatic hyperplasia. However, the reviewed studies were small in size, were of short duration, used varied doses and preparations and rarely reported outcomes using standardized validated measures of efficacy. Additional placebo-controlled trials are needed as well as studies that compare Pygeum africanum to active controls that have been convincingly demonstrated to have beneficial effects on lower urinary tract symptoms related to BPH. These trials should be of sufficient size and duration to detect important differences in clinically relevant endpoints and use standardized urologic symptom scale scores.

The effect of Pygeum africanum on fibroblast growth factor (FGF) and transforming growth factor beta (TGF beta 1/LAP) expression in animal model.
Acta Microbiol Immunol Hung. 2001;48(1):1-9.
On the basis of its fibroblast growth factor (FGF) inhibitory effect we assessed the possible inhibitory anti-inflammatory role of Pygeum Africanum extract (Tadenan) on FGF and transforming growth factor beta (TGF beta 1/LAP) expression of macrophages and neutrophils in broncho-alveolar lavage fluid of rats in a bleomycin-induced acute inflammation model. The rats were divided into three groups: 17 untreated controls, 10 bleomycin-instilled rats), and 10 rats receiving Pygeum Africanum extract. We found in Pygeum Africanum extract treated group 1, a significantly decreased number of neutrophil granulocytes compared with other groups 2, there was a considerable decrease on BAL macrophages, but not in case of FGF. In conclusion: our results show the possible 1. inhibitory effect of pygeum on TGF beta 1 (LAP) expression, 2. anti-inflammatory role on neutrophil granulocytes.

Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis.
Am J Med. 2000 Dec 1;109(8):654-64.
To conduct a systematic review and quantitative meta-analysis of the therapeutic efficacy and tolerability of Pygeum africanum in men with symptomatic benign prostatic hyperplasia. Studies were identified through the search of Medline (1966 to 2000), Embase, Phytodok, the Cochrane Library, bibliographies of identified trials and review articles, and contact with relevant authors and drug companies. Randomized trials were included if participants had symptomatic benign prostatic hyperplasia, the intervention was a preparation of Pygeum africanum alone or in combination with other phytotherapeutic agents, a control group received placebo or other pharmacologic therapies for benign prostatic hyperplasia, and treatment duration was at least 30 days. Compared with placebo in 6 studies, pygeum provided a moderately large improvement in the combined outcome of urologic symptoms and flow measures. Summary estimates of individual outcomes were also improved by Pygeum africanum. Men were more than twice as likely to report an improvement in overall symptoms. Nocturia was reduced by 19% and residual urine volume by 24%; peak urine flow was increased by 23%. Adverse effects due to Pygeum africanum were mild and similar to placebo. The overall dropout rate was 12% and was similar for Pygeum africanum, placebo, and other controls. The literature on Pygeum africanum for the treatment of benign prostatic hyperplasia is limited by the short duration of studies and the variability in study design, the use of phytotherapeutic preparations, and the types of reported outcomes. However, the evidence suggests that Pygeum africanum modestly, but significantly, improves urologic symptoms and flow measures. Further research is needed using standardized preparations of Pygeum africanum to determine its long-term effectiveness and ability to prevent complications associated with benign prostatic hyperplasia.

Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients with benign prostatic hyperplasia: a randomized, double-blind study, with long-term open label extension.
Urology. 1999 Sep;54(3):473-8.
To compare the efficacy and safety of Pygeum africanum extract, 50 mg twice daily and 100 mg once daily. Patients with symptomatic benign prostatic hyperplasia (BPH) entered a 2-month randomized, parallel-group, double-blind, comparative phase (group A, 50 mg pygeum twice daily; group B, 100 mg pygeum once daily), followed by a 10-month, open phase (100 mg once daily). Pygeum africanum extract at 50 mg twice daily and 100 mg once daily proved equally effective and safe at 2 months. Further improvements in efficacy with a satisfactory safety profile were documented after 12 months.