Pyrogallol health benefit and use for cancer prevention or treatment

Pyrogallol is a polyphenol. Pyrogallol, a catechin compound, is an active component of emblica officinalis herbal extracts and has an anti-proliferative effect on some human cancer cell lines. This substance induces apoptosis (cell destruction) in several types of cells mediated by superoxide anion.

Review of published trials
Pyrogallol inhibits the growth of lung cancer Calu-6 cells via caspase-dependent apoptosis.
Chem Biol Interact. 2009, Medical School, Centers for Healthcare Technology Development, Institute for Medical Sciences, Chonbuk National University, JeonJu, Republic of Korea.
Pyrogallol is a polyphenol compound and a known O2- generator. We evaluated the effects of Pyrogallol on the growth and apoptosis of human pulmonary adenocarcinoma Calu-6 cells. Pyrogallol decreased the viability of Calu-6 cells in a dose- and time-dependent manner. The induction of apoptosis by Pyrogallol was accompanied by the loss of mitochondrial membrane potential (DeltaPsi(m)), cytochrome c release from mitochondria and activation of caspase-3 and caspase-8. Pyrogallol inhibits the growth of Calu-6 cells via caspase-dependent apoptosis.

Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model.
Lung Cancer. 2009, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
In our preliminary study, pyrogallol had highly cytotoxic effect on human lung cancer cell lines and less effect on human bronchial epithelium cell line. This study was performed to investigate the beneficial effect of pyrogallol on human lung cancer cell lines - H441 (lung adenocarcinoma) and H520 (lung squamous cell carcinoma). Taken in vitro and in vivo studies together, these results suggest that pyrogallol can be developed as a promising anti-lung cancer drug particular for the non-small cell lung cancer (NSCLC).

J Agric Food Chemistry. 2016. Identification of Pyrogallol in the Ethyl Acetate-Soluble Part of Coffee as the Main Contributor to Its Xanthine Oxidase Inhibitory Activity.

Food Funct. 2016. Pyrogallol, an absorbable microbial gallotannins-metabolite and mango polyphenols (Mangifera Indica) suppress breast cancer ductal carcinoma in situ proliferation in vitro.Nemec MJ1, Kim H, Marciante AB, Barnes RC, Talcott ST, Mertens-Talcott SU. Mango is rich in bioactive absorbable polyphenols, but also contains considerable amounts of unabsorbable gallotannins at varying degrees of polymerization. Gallotannins are not absorbable upon consumption and have rarely been considered in the discussion of health benefits of polyphenols. Therefore, the objective of this study was to investigate the anti-proliferative activities of the major microbial metabolite of gallotannins, pyrogallol (PG) and a low molecular weight fraction of mango (Mangifera Indica L.) polyphenols (ML) and involved pathways including the AKT/mTOR signaling axis in an in situ breast cancer cell line