Pyroglutamate supplement by Ray Sahelian, M.D.
February 1 2016

Pyroglutamate is also known as 2-oxo-pyrrolidone carboxylic acid or PCA and 5-oxoproline. Pyroglutamate is an intermediate of the gamma-glutamyl cycle of glutathione synthesis and degradation. I did a thorough Medline search for pyroglutamate and could not find any published studies except the one below. Pyroglutamate is structurally related to the drug piracetam, which has been studies more thoroughly. Piracetam is known as a smart drug.
   A review of published research on Medline in February 2016 did not show any recent human studies with pyroglutamate supplement.

Does it work, is it effective?
I'm not sure what to say about pyroglutamate. It's possible it has cognition enhancing abilities but I'll reserve my judgment when I see additional published studies. In the meantime, there are many other effective mind boosters including Acetyl-l-carnitine antioxidant and brain booster, Lipoic Acid, CDP-Choline, DMAE, and others. You can learn more about these in a book called Mind Boosters.

Mind Power Rx combines a smart balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support:

Mental clarity
Alertness & Focus



The herbsare: Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba,  Ginseng, Gotu kola, Mucuna pruriens, Reishi, and Rhodiola.  The nutrients and vitamins in Mind Power Rx include Acetyl-l-carnitine, Carnitine, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine.

Pyroglutamic acid improves the age associated memory impairment.
Cattedra di Patologia Neurologica II dell'Universita di Catania, Italy. Fundam Clin Pharmacol.
Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with pyroglutamic acid and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by means of a battery made up of 6 memory tasks. The results suggest that pyroglutamate is effective in improving some verbal memory functions in subjects affected by age-related memory decline.

Anticancer Agents Med Chem. December 2013. Stereoselective synthesis of pyroglutamate natural product analogs from α- aminoacids and their anti-cancer evaluation.Tekkam S, Alam MA, Just MJ, Berry SM, Johnson JL, Jonnalagadda SC, Mereddy VR.Author informationAbstractAlkylation of α-amino acid derived iminoesters with Baylis-Hillman (BH) reaction template based allyl bromides/allyl acetates followed by acidic hydrolysis furnished α-methylene-β-substituted-pyroglutamates and α-alkylidene pyroglutamates respectively. Application of these methodologies has been demonstrated in the synthesis of fused [3.2.0]-γ-lactam-β-lactones. Further, substrate controlled stereoselective alkylation of L-threonine derived oxazoles with BH reaction based allyl bromides and acetates yielded optically pure α-methylene-β-substituted pyroglutamates, and α-alkylidene pyroglutamates. These methodologies have been applied in the preparation of chiral [3.2.0] heterobicyclic pyroglutamates containing hydroxyethyl side chain. All the synthesized pyroglutamates have been evaluated for their anti-cancer and enzyme proteasome inhibition activity.

Ir Med J. 2011. Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs. Pyroglutamic aciduria is a rare and probably under-recognised cause of metabolic acidosis which may be precipitated by certain common drugs.

I’m taking smart pills pyroglutamate with piracetam, and I’m feeling very energized with a keen feeling of concentration. Piracetam at 200 mg only gave a feeling of confusion, but as soon as I combine it with this pyroglutamate, the effects were remarkable. My short term memory has also increased.

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What is arginine Pyroglutamate?
    It is the L-arginine salt of pyroglutamic acid. Arginine pyroglutamate is also called pirglutargine or arginine pidolate.