Pyroglutamate supplement by Ray Sahelian, M.D.

Pyroglutamate is also known as 2-oxo-pyrrolidone carboxylic acid or PCA and 5-oxoproline. Pyroglutamate is an intermediate of the gamma-glutamyl cycle of glutathione synthesis and degradation. I did a thorough Medline search for pyroglutamate and could not find any published studies except the one below. Pyroglutamate is structurally related to the drug piracetam, which has been studies more thoroughly. Piracetam is known as a smart drug.
   A review of published research on Medline in December of 2007 did not show any recent human studies with pyroglutamate supplement.

Pyroglutamate summary
I'm not sure what to say about pyroglutamate. It's possible pyroglutamate has cognition enhancing abilities but I'll reserve my judgment when I see additional published studies. In the meantime, there are many other effective mind boosters including Acetyl-l-carnitine antioxidant and brain booster, Lipoic Acid, CDP-Choline, DMAE, and others. You can learn more about these in a book called Mind Boosters.

Mind Power Rx - Formulated by Ray Sahelian, M.D.

Mind Power Rx is a sophisticated cognitive formula. It combines a delicate balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support:
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The herbs in Mind Power Rx include: Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba,  Ginseng, Gotu kola, Mucuna pruriens, Reishi, and Rhodiola.  The nutrients and vitamins in Mind Power Rx include Acetyl-l-carnitine, Carnitine, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine. Click Physician Formulas below in blue

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Pyroglutamic acid improves the age associated memory impairment.
Cattedra di Patologia Neurologica II dell'Universita di Catania, Italy.
Fundam Clin Pharmacol 1990;4(2):169-73
Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with pyroglutamic acid and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by means of a battery made up of 6 memory tasks. The results suggest that pyroglutamate is effective in improving some verbal memory functions in subjects affected by age-related memory decline.