Activated Quercetin and Bromelain
Source Naturals
Activated Quercetin with bromelain is a unique bioflavonoid derived product from plant sources. In human cell culture studies, quercetin has been shown to inhibit histamine release. Additional research needs to be conducted to increase our awareness of the benefits of quercetin in humans. Bromelain is a pineapple enzyme.

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Quercetin Bromelain supplement facts:
Vitamin C (as magnesium ascorbate)
Magnesium (as magnesium ascorbate)
Quercetin - 1 gram per 3 capsules
Bromelain
Quercetin and Bromelain daily values are not established.

Quercetin and prostate health
Preliminary  studies indicate that quercetin my inhibit the proliferation of androgen-independent human prostatic tumor cells. In rats, quercetin, in combination with finasteride, reduces prostate weight. Whether quercetin therapy alone benefits those with benign prostate hyperplasia is not clearly known at this time.

Eyesight Rx with Quercetin
Supports Healthy Vision
Developed by Ray Sahelian, M.D.

Unlike some vision products that provide nutrients and herbs for long term healthy vision support, and prevention of visual impairment, but don't seem to have much of an immediate effect on visual acuity, Eyesight Rx was formulated to provide a quick and noticeable vision improvement within hours or days of use. Reports from Eyesight Rx users indicate enhanced clarity of vision, colors being brighter, better focus, and overall improvement in close and distance vision.
Click Quercetin above in blue for more information on Eyesight Rx

Benefit of quercetin
Quercetin is a powerful antioxidant. Many flavonoids, including quercetin, can act as aromatase inhibitors. Potential quercetin benefits that are still being discovered. Here's a summary of some of the quercetin benefit research studies.

Quercetin and allergy
I have not come across any good human studies evaluating the role of allergy and quercetin supplements. However, quercetin, as a flavonoid, has been shown in lab studies to have blunt the effects of IgE mediated reactions and perhaps have anti histamine effects There are several nutrients and herbs, in addition to quercetin, that have had some research in terms of their influence on allergy, these include urtica dioica, bromelain, acetylcysteine, and vitamin C.

Quercetin and cancer
Quercetin has anti-tumor potential in laboratory studies, and has potential to be useful in various cancers including pancreatic cancer, however human trials are difficult to find.

Quercetin and heart disease
Quercetin may benefit those with heart disease. Quercetin inhibits the proliferation and migration of aortic smooth muscle cells, inhibits platelet aggregation, along with inhibition of mitogen-activated protein kinase phosphorylation. These findings provide new insights and a rationale for the potential benefit of quercetin in the prevention of cardiovascular diseases.

Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study.
Br J Nutr. 2006 Sep;96(3):482-8. School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, Berkshire, RG6 6AL, UK.
Those who consume a diet rich in quercetin containing foods may have a reduced risk of cardiovascular disease. In vitro and ex vivo studies have observed the inhibition of collagen-induced platelet activation by quercetin. The aim of the present study was to investigate the possible inhibitory effects of quercetin ingestion from a dietary source on collagen-stimulated platelet aggregation. Subjects ingested a soup containing either a high or a low amount of quercetin. Plasma quercetin concentrations and platelet aggregation and signalling were assessed after soup ingestion. The high- quercetin soup contained 69 mg total quercetin compared with the low- quercetin soup containing 5 mg total quercetin. Plasma quercetin concentrations were significantly higher after high- quercetin soup ingestion than after low- quercetin soup ingestion. Collagen-stimulated (0.5 mug/ml) platelet aggregation was inhibited after ingestion of the high- quercetin soup in a time-dependent manner. The ingestion of quercetin from a dietary source of onion soup could inhibit some aspects of collagen-stimulated platelet aggregation and signalling. This further substantiates the epidemiological data suggesting that those who preferentially consume high amounts of quercetin containing foods have a reduced risk of thrombosis and potential cardiovascular disease risk.

Quercetin, common cold, and immune health
Quercetin, a naturally occurring, powerful antioxidant found in red grapes, red wine, red apples, green tea and broccoli, appears to be one of the first plant compound proven in a double-blind, randomized, placebo-controlled clinical trial to reduce susceptibility to viral illnesses. Dr. David Nieman, a professor at Appalachian State University was the researcher and presented his findings at the southeastern regional meeting of the American College of Sports Medicine in Charlotte, N.C. Participants in the study -- long-distance cyclists -- ingested 1,000 milligrams of pure quercetin, combined with vitamin C and niacin.

Quercetin reduces illness but not immune perturbations after intensive exercise.
Med Sci Sports Exerc. 2007 September. Nieman DC, Henson DA, Gross SJ, Jenkins DP, Davis JM, Murphy EA, Carmichael MD, Dumke CL, Utter AC, McAnulty SR, McAnulty LS, Mayer EP. Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC
To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections and exercise-induced changes in immune function. Trained male cyclists were randomized to quercetin or placebo  groups and, under double-blind procedures, received 3 weeks quercetin (1000 mg a day) or placebo before, during, and for 2 weeks after a 3-d period in which subjects cycled for 3 hours a day at approximately 57% Wmax. Blood and saliva samples were collected before and after each of the three exercise sessions and assayed for natural killer cell activity (NKCA), PHA-stimulated lymphocyte proliferation (PHA-LP), polymorphonuclear oxidative-burst activity (POBA), and salivary IgA output (sIgA). Pre- to postexercise changes in NKCA, PHA-LP, POBA, and sIgA did not differ significantly between quercetin and placebo groups. Upper respiratory tract infection incidence during the 2-wk postexercise period differed significantly between groups. Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced upper respiratory tract infection incidence in cyclists during the 2-wk period after intensified exercise.

Quercetin and liver
The liver of rats given toxins was much better protected when they were pre-treated with quercetin.

Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents.
 Phytomedicine. 2004 Jul;11(5):424-30.
Caffeic acid and quercetin, the well-known phenolic compounds widely present in the plant kingdom, were investigated for their possible protective effects against paracetamol and CCl4-induced hepatic damage. Paracetamol at the oral dose of 1 g/kg produced 100% mortality in mice while pretreatment of separate groups of animals with caffeic acid and quercetin reduced the death rate to 20% and 30%, respectively. Oral administration of sub-lethal dose of paracetamol produced liver damage in rats as manifested by the significant rise in serum levels of aminotransferases (aspartate transaminase (AST) and alanine transaminase (ALT)) compared to respective control values. The serum enzyme values were significantly lowered on pretreatment of rats with either caffeic acid or quercetin. Similarly, the hepatotoxic dose of CCl4 also raised significantly the serum AST and ALT levels as compared to control values. The same dose of the caffeic acid and quercetin was able to prevent CCl4-induced rise in serum enzymes. These results indicate that caffeic acid and quercetin exhibited hepatoprotective activity possibly through multiple mechanisms.

Quercetin and kidney disease
Quercetin reduces damage to kidneys in rats given a toxin or a chemotherapy drug such as cisplatin.

Protective Effect of Quercetin on the Evolution of Cisplatin-Induced Acute Tubular Necrosis.
Kidney Blood Press Res. 2004 Apr 30;27(3):148-158.
The bioflavonoid quercetin may be a potential alternative to reduce cisplatin-induced nephrotoxicity. The aim of this study was to evaluate the effect of quercetin on the evolution of cisplatin-induced acute tubular necrosis. One hundred and three male Wistar rats were injected with cisplatin 43 of them received quercetin (50 mg/kg, by gavage) before cisplatin injection. Cisplatin-treated rats presented a transitory increase in plasma creatinine levels, tubular cell necrosis and increased immunostaining for vimentin, alpha-SM-actin, fibronectin, ED1, NF-kappaB, and p-JNK in the renal cortex and outer medulla. These alterations were less intense in animals treated with quercetin. Quercetin treatment attenuated the functional, histological and immunohistochemical alterations induced by cisplatin.

Quercetin, a bioflavonoid, attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats.
Drug Chem Toxicol. 2004 May;27(2):145-56.
An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage, that eventually leads to high incidence of renal adenocarcinomas in rodents. This study was designed to investigate the effect of quercetin, a bioflavonoid with antioxidant potential, on Fe-NTA-induced nephrotoxicity in rats. One hour after a single intraperitoneal (i.p.) injection of Fe-NT, a marked deterioration of renal architecture and renal function was observed. Pretreatment of animals with quercetin 30 minutes before Fe-NTA administration markedly attenuated renal dysfunction, morphological alterations, and restored the depleted renal antioxidant enzymes. These results demonstrate the role of oxidative stress and its relation to renal dysfunction, and suggest a protective effect of quercetin on Fe-NTA-induced nephrotoxicity in rats.

Quercetin and prostate health
Q. I am a researcher in Australia and came across your website offering quercetin products. I note that quercetin interacts with finasteride, which may affect that product's effect in reducing hair loss: "Finasteride alone caused a significant decrease in serum DHT level and prostate weight. Co-administration of quercetin with finasteride prevented the finasteride-induced decrease in serum DHT levels." My question is; in your opinion, will this impact on the benefit of finasteride's reduction in hair loss by reducing serum DHT?
   A. I have a summary of the study below. The amount of quercetin given the rats per body weight is much higher than what a person would normally ingest. I think rodent studies are helpful but I do not rely on them much since over the years I have seen very different or even completely opposite results in humans. The 100 mg per kg of body weight given to a rat would be about 7000 mg in humans. Even if 3 capsules of quercetin are taken, this would amount to 1000 mg, seven times less than in the rodent. This could make a significant difference. Add to this the different hormonal status in humans compared to rodents, different diets, sleep patterns, liver metabolism, etc. All this gives too many variables to make heads or tails (excuse the pun) from the results of this study. If I interpret the results of this study further, you can see that the different dosage of quercetin led to different levels of DHT, one dose let to a 125% increase, while another dosage led to a decrease to 73 percent of the control.

Reduction of rat prostate weight by combined quercetin - finasteride treatment is associated with cell cycle deregulation.
J Endocrinol. 2004 Jun;181(3):493-507.
Benign prostate hyperplasia and prostate cancer are major public health problems. We report herein that daily treatment of male rats with 50, 100 or 150 mg quercetin per kg body weight. Concomitantly, serum testosterone levels were increased by 1.79-, 1.83- and 3.48-fold, while serum dihydrotestosterone (DHT) levels were 125%, 92% and 73% of the control. A slight increase in prostate weight coupled with dilated prostate lumens full of secretory materials were observed. Finasteride alone caused a significant decrease in serum DHT level and prostate weight. Co-administration of quercetin with finasteride prevented the finasteride-induced decrease in serum DHT levels but significantly enhanced the reduction in wet prostate weight, which was reduced by 26.9% in finasteride-treated animals to 31.8%, 40.0% and 48.2% after finasteride given together with the three doses of quercetin. The combined treatment altered cell cycle-regulated proteins in a wide spectrum. In conclusion, quercetin - finasteride treatments caused wide cell cycle deregulation in rat prostates, which, in turn, decreased the proliferation rate, changed the secretion activities of epithelial cells and resulted in a marked reduction in wet prostate weight. The results suggest that quercetin synergizes with finasteride to reduce the wet prostate weight through a cell cycle-related pathway, which may be androgen independent.

Quercetin and prostatitis
I was made aware of this study by Dr. David C. Leopold, MD  who is at Scripps Center for Integrative Medicine in La Jolla, California.

Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.
Urology. 1999 Dec;54(6):960-3. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Institute for Male Urology, Encino, California, USA.
The National Institutes of Health (NIH) category III chronic prostatitis syndromes (nonbacterial chronic prostatitis and prostatodynia) are common disorders with few effective therapies. Thirty men with category IIIa and IIIb chronic pelvic pain syndrome were randomized in a double-blind fashion to receive either placebo or the bioflavonoid quercetin 500 mg twice daily for 1 month. The NIH chronic prostatitis symptom score was used to grade symptoms and the quality-of-life impact at the start and conclusion of the study. In a follow-up unblind, open-label study, 17 additional men received 1 month of a supplement containing quercetin, as well as bromelain and papain (Prosta-O), which enhance bioflavonoid absorption. Patients taking placebo had a mean improvement in NIH symptom score from 20 to 18 (not significant), while those taking the bioflavonoid had a mean improvement from 21 to 13. Twenty percent of patients taking placebo and 67% of patients taking the bioflavonoid had an improvement of symptoms of at least 25%. In the 17 patients who received Prosta-Q in the open-label study, 82% had at least a 25% improvement in symptom score. Therapy with the bioflavonoid quercetin is well tolerated and provides significant symptomatic improvement in most men with chronic pelvic pain syndrome.

Q. Is quercetin effective for prostatitis?
   A. One study shows quercetin helps prostatitis, a prostate infection or inflammation. Quercetin has potential as one nutrient out of many to be helpful in prostate enlargement. The dose of quercetin used in the prostatitis study was 500 mg twice daily. We will need a few more studies regarding the role of quercetin in the treatment of prostatitis to have a clearer idea of the benefits of this supplement for this condition.

Brain tissue and schizophrenia
Quercetin has potential for the treatment of neuroleptic-induced extrapyramidal side effects, such as from the drug haloperidol. Quercetin is a powerful antioxidant that may protect brain cells from damage.

Quercetin, a bioflavonoid, reverses haloperidol-induced catalepsy.
Methods Find Exp Clin Pharmacol. 2004 Jun;26(5):323-6.
Neuroleptics are extensively used in the treatment of schizophrenia and other affective disorders. Unfortunately their use is often associated with distressing side effects involving the extrapyramidal tract, such as Parkinsonism and tardive dyskinesia. Neuroleptic-induced catalepsy has long been used as a model for extrapyramidal side effects such as Parkinsonian-like bradykinesia associated with antipsychotic use in humans. In the present study, haloperidol was administered to mice to induce catalepsy. Pretreatment with quercetin dose-dependently reduced the catalepsy score in haloperidol-treated animals. The findings of the present study strongly suggest that quercetin can be screened as a potential drug candidate or as an adjuvant for the treatment of neuroleptic-induced extrapyramidal side effects.

Quercetin side effects
At this time quercetin side effects have not been reported in the medical literature. I have personally taken 3 capsules of quercetin and bromelain for 3 days in a row without side effects. Quercetin side effects with long term supplementation over several years is not known.

Food content of flavonoids
The average U.S. adult eating a normal, healthy diet consumes about 25 to 50 milligrams of quercetin a day. Studies were conducted on the flavonoids (myricetin, quercetin, kaempferol, luteolin, and apigenin) contents of 62 edible tropical plants. The highest total flavonoids content was in onion leaves (1497 mg/kg quercetin, 391 mg/kg luteolin, and 832 mg/kg kaempferol), followed by Semambu leaves (2041 mg/kg), bird chili (1663 mg/kg), black tea (1491 mg/kg), papaya shoots (1264 mg/kg), and guava (1128 mg/kg). The major flavonoid in these plant extracts is quercetin, followed by myricetin and kaempferol. Luteolin could be detected only in broccoli (74 mg/kg dry weight), green chili (33 mg/kg), bird chili (1035 mg/kg), onion leaves (391 mg/kg), carrot (37 mg/kg), white radish (9 mg/kg), local celery (80 mg/kg) and dried asam gelugur (107 mg/kg). Apigenin was found only in Chinese cabbage (187 mg/kg), bell pepper (272 mg/kg), garlic (217 mg/kg), French peas (176 mg/kg), snake gourd (42 mg/kg), guava (579 mg/kg), wolfberry leaves (547 mg/kg), local celery (338 mg/kg), and kadok (34 mg/kg). In vegetables, quercetin glycosides predominate, but glycosides of kaempferol, luteolin, and apigenin are also present. Fruits contain almost exclusively quercetin glycosides, whereas kaempferol and myricetin glycosides are found only in trace quantities.

Quercetin research update
Quercetin exerts antihypertensive effects and reduces left ventricular hypertrophy, endothelial dysfunction, and the plasma and hepatic oxidative status in spontaneously hypertensive rats.

Antimutagenic and antioxidant / prooxidant activity of quercetin.
Indian J Exp Biol. 2005 Jan;43(1):61-7.
The present study has been performed to evaluate the antimutagenic activity of quercetin, ascorbic acid and their combination against an oxidative mutagen. Quercetin and ascorbic acid showed significant effect. Quercetin when combined with ascorbic acid showed an increase in the antimutagenic activity. In vitro antioxidant activity of quercetin was better than ascorbic acid in all the test systems used. The study indicated that the antimutagenic activity of quercetin was not solely accountable by its antioxidant nature. However, in vitro free radical scavenging activity of quercetin correlated well with the antimutagenic activity.

Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries.
J Agric Food Chem. 1999 Jun;47(6):2274-9.
The amounts of quercetin, myricetin, and kaempferol aglycons in 25 edible berries were analyzed. Sixteen species of cultivated berries and nine species of wild berries were collected in Finland in 1997. Quercetin was found in all berries, the contents being highest in bog whortleberry (158 mg/kg, fresh weight), lingonberry (74 and 146 mg/kg), cranberry (83 and 121 mg/kg), chokeberry (89 mg/kg), sweet rowan (85 mg/kg), rowanberry (63 mg/kg), sea buckthorn berry (62 mg/kg), and crowberry (53 and 56 mg/kg). Amounts between 14 and 142 mg/kg of myricetin were detected in cranberry, black currant, crowberry, bog whortleberry, blueberries, and bilberry. Kaempferol was detected only in gooseberries (16 and 19 mg/kg) and strawberries (5 and 8 mg/kg). Total contents of these flavonols (100-263 mg/kg) in cranberry, bog whortleberry, lingonberry, black currant, and crowberry were higher than those in the commonly consumed fruits or vegetables, except for onion, kale, and broccoli.

An apple a day really does keep the doctor away, thanks to strong antioxidants that fight cell damage. Rat brain cells exposed to the antioxidant quercetin resisted damage much better than those not treated, a team at Cornell University in New York found. The researchers say their study adds strength to the theory that the risk of developing Alzheimer's and similar brain diseases might be reduced by eating plenty of fresh fruits and vegetables. Writing in the December 1st issue of the Journal of Agricultural and Food Chemistry, the Cornell team said they soaked rat brain cells in either quercetin or vitamin C -- another potent antioxidant. The cells were then exposed to hydrogen peroxide to mimic the type of oxidative cell damage that is believed to occur with Alzheimer's disease. Brain cells that were treated with quercetin had significantly less damage than the cells treated with vitamin C and cells that were not treated with antioxidants.

Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction.
J Nutr. 2004 Apr;134(4):771-5.
Consumption of plant phenolics, such as quercetin, may be associated with decreased risk of cardiovascular disease by stabilizing and protecting vascular endothelial cells against oxidative and proinflammatory insults. The present study focused on the effect of quercetin on linoleic acid-induced oxidative stress. Porcine pulmonary-arterial endothelial cells were activated with linoleic acid in the presence or absence of quercetin. Oxidative stress was markedly induced by endothelial cell exposure to linoleic acid and diminished by treatment with quercetin. Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1. Cotreatment of linoleic acid plus quercetin or vitamin E also decreased linoleic acid-induced binding activity of PPARgamma. These data suggest that quercetin has potent antioxidative and anti-inflammatory properties and protects endothelial cells against linoleic acid-mediated cell dysfunction.

Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations.
Eur J Clin Nutr. 2003 Jan;57(1):37-42.
To study serum quercetin concentrations of subjects consuming berries or habitual Finnish diets. Forty healthy men (age 60 y). Twenty subjects consumed 100 g/day of berries (black currants, lingonberries and bilberries) for 8 weeks. Twenty subjects consuming their habitual diets served as controls. Fasting blood samples were obtained 2 weeks prior to the study, at baseline, and at 2, 4 and 8 weeks. Intake of quercetin was assessed from 3 day food records collected at baseline and at 8 weeks. The serum quercetin concentrations were significantly higher in the subjects consuming berries compared to the control group. During the berry consumption period the mean serum concentrations of quercetin ranged between 21 and 25 micro g/l in the berry group, which was 32-51% higher compared with the control group. According to 3 day food records, there was no difference in quercetin intake at baseline, but at 8 weeks the intake was 12.3 mg/day in the berry group and 5.8 mg/day in the control group. The results indicate that the berries used in this study are a good source of bioavailable quercetin.

Plant compounds may curb cancer growth
Several studies have shown that a group of antioxidant compounds found in grapes, green tea, soybeans and wine may lower the risk of a range of cancers, but exactly how these powerful compounds work has remained unclear. Now, researchers report that a plant-derived polyphenol can slow the growth of pancreatic cancer cells in mice and curb the spread of cells by triggering a series or reactions that causes the cells to self-destruct, a process known as apoptosis. In the study, the researchers investigated the effects of quercetin -- a type of antioxidant polyphenol commonly found in apples -- in mice given injections of human pancreatic cells. The mice used in the study are a specially bred strain that lacks an immune system, so that they quickly grow tumors when cancer cells are injected. Quercetin caused apoptosis, decreased the growth of the main tumor and inhibited the spread of malignant cells, the researchers report. Mice treated with quercetin survived for about 75 days, compared with 67 days in mice not given the compound. Genistein, another type of polyphenol compound found in soy, also prevented the spread of cells and inhibited the growth of the primary tumor in mice while resveratrol, found in wine and grapes, caused apoptosis in laboratory-grown cells, according to the report. International Journal of Cancer 2002:98;761-769.

Effects of chronic quercetin treatment on antioxidant defense system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats.
Mol Cell Biochem. 2004 Apr;259(1-2):91-9.
We investigated the potential of chronic administration of an oral daily dose of the dietary flavonoid quercetin to prevent hypertension and oxidative stress induced by deoxycorticosterone acetate in rats.  In conclusion, quercetin shows both antihypertensive and antioxidant properties in this model of mineralocorticoid hypertension, while verapamil exhibits only antihypertensive effects.

Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations.
Eur J Clin Nutr. 2003 Jan;57(1):37-42.
To study serum quercetin concentrations of subjects consuming berries or habitual Finnish diets. DESIGN: Randomized parallel dietary intervention. Forty healthy men (age 60 y). INTERVENTION: Twenty subjects consumed 100 g/day of berries (black currants, lingonberries and bilberries) for 8 weeks. Twenty subjects consuming their habitual diets served as controls. Fasting blood samples were obtained 2 weeks prior to the study, at baseline, and at 2, 4 and 8 weeks. Intake of quercetin was assessed from 3 day food records collected at baseline and at 8 weeks. RESULTS: The serum quercetin concentrations were significantly higher in the subjects consuming berries compared to the control group. During the berry consumption period the mean serum concentrations of quercetin ranged between 21.4 and 25.3 micro g/l in the berry group, which was 32-51% higher compared with the control group. According to 3 day food records, there was no difference in quercetin intake at baseline, but at 8 weeks the intake was 12 mg/day in the berry group and 5 mg/day in the control group. The results indicate that the berries used in this study are a good source of bioavailable quercetin.

Quercetin emails
Q. What is the difference between quercetin and quercetin chalcone?
   A. I don't know for sure. Chalcones are also intermediates in the biosynthesis of flavonoids, and quercetin chalcone may just be a form of quercetin slightly different biochemically than regular quercetin.

Q. As one professional to another, I would appreciate your clinical advice. Some studies indicate quercetin can exert a net pro-inflammatory response (albeit at high doses in combination with other bioflavinoids). Some researchers have claimed quercetin might cause inflammatory responses involving the PIP, MIP and Dip joints of the hands and feet; some claim an altered uric acid metabolism. Have you any experience in this regard? I have started quercetin at 250 mg bid (along with saw palmetto, zinc/copper and nettle leaf) to balance my DHT-T-E ratio and have experienced a new onset of said joint effects.
   A. I have not come across any studies and do not have any personal feedback from quercetin users regarding the association between quercetin and joint pain.

Q. I have been taking a formula which contains 250 MG of quercetin. I have been taking 4 pills a day. It works great for allergies but I recently found out I am pregnant. I came across some warnings of birth defects. Of course I am very upset and hoping you might have some access to studies or info regarding the use of quercetin during conception. I am only 5 weeks pregnant.
   A. I have not seen any human studies regarding the use of quercetin supplements during pregnancy. I found this rodent study which appears to be reassuring regarding implantation. The human dosage often taken is about 10 to 20 mg quercetin per kilo. Your doctor needs to make the final decision regarding continuing or stopping the quercetin.

Additional quercetin studies
Studies on germinal effects of quercetin, a naturally occurring flavonoid.
Mutat Res. 1985 Oct;144(2):99-106.
Quercetin is one of the most widely occurring flavonoids ingested by man in food. Adult Swiss males were treated with 200, 300 or 400 mg/kg of quercetin dissolved in 60% dimethyl sulfoxide, intraperitoneally. In the rat study, 200 and 300 mg/kg of quercetin were used. Individually caged males were paired with untreated females for a week and six sequential matings were carried out. Two independent experiments in mice and a single experiment in rats constituted the study. Females were evaluated for inducted dominant lethality during the midterm of pregnancy. At 200 mg/kg dose of quercetin, there were no significant differences between control and the test group in pregnancy, total or live implantations in mice or rats during the whole test period that could be attributed to the flavonoid exposure. In mice at 300 and 400 mg/kg of quercetin, there was a profound reduction in fertility of the males during all six matings. The number of total and live implantations also decreased, particularly at the 400 mg/kg dose, although the sample size was too small to be statistically significant. Contrary to this, the rat study did not show any impairment of fertility, nor was there any substantial suppression of total and live implantations at the highest (300 mg/kg) dose tested. There were no significant differences between control and treated groups with regard to the number of dead implantations at any dosage level at any stage of the study in mice and rats. Thus, no post-implantation losses--a reliable measure of dominant lethal mutations--were induced by quercetin in mice or rats.

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This quercetin page was last updated in January 2008.