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Rehmannia rutinosa information
Rehmannia product for sale
Passion Rx libido product with rehmannia root, formulated by Ray Sahelian, M.D. - works in men and women

Rehmannia root powder has been used to enhance energy. Rehmannia root is native to China, Japan, and Korea. Traditionally, rehmannia root has been used to replenish vitality, strengthen the liver, kidney, and heart, and for treatment of a variety of ailments like diabetes, anemia, and urinary tract problems. Rehmannia is sometimes included in sexual enhancement products.

Rehmannia Rutinosa studies
Rehmannia glutinosa has been shown to help maintain healthy blood sugar levels.
Rehmannia is involved in red blood cell regeneration.
May be involved in anti tumor activity.

Rehmannia Endurance, 637 mg, 150 Tabs - Planetary Formulas

Planetary Formulas Rehmannia Endurance is based on the classic Chinese tonifer Rehmannia Six: Liu Wei Di Huang Wan, one of the most strengthening tonics of Chinese herbalism. Traditionally it was used for those who are tired and run down from overwork and inadequate rest due to a fast paced-lifestyle.

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Rehmannia Supplement Facts:
Calcium - 128 mg - 15%DV
Rehmannia Root - 320 mg *
Poria Cocos Sclerotium - 160 mg *
Tree Peony Root Bark - 160 mg *
Dioscorea Root - 160 mg *
Alisma Rhizome - 160 mg *
He Shou Wu Root (Fo Ti) - 80 mg *
Chrysanthemum Flower - 64 mg *
Ligustrum Seed - 64 mg +
Saw Palmetto Berry - 48 mg *
Lycii Fruit Extract - 40 mg *
Cornus Fruit - 18 mg *

Suggested Use: Half or one rehmannia tablet in the morning a few times a week, or as recommended by your health care professional.
* Rehmannia Revitalizer daily value not established

Benefit of rehmannia herb
Rehmannia is used to enhance energy and sexuality, and it could also have benefits in terms of blood sugar control. In China, it has been used for certain hearing problems.

Rehmannia for blood sugar control
Hypoglycemic effect of rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism.
J Ethnopharmacol. 2004 Jan;90(1):39-43.
The hypoglycemic and anti-diabetic effect of Rehmannia glutinosa oligosaccharide in glucose-induced hyperglycemic and alloxan-induced diabetic rats and its mechanism was investigated. It was found that pretreatment of rehmannia in normal rats induced a partial prevention of hyperglycemia caused by glucose, while when hyperglycemia was induced in adrenalectomized rats, the preventive effect of rehmannia on hyperglycemia was lost. The results indicated that oligosaccharide of Rehmannia glutinosa exert a significant hypoglycemic effect in normal and alloxan-induced diabetic rats.

Passion Rx with Rehmannia Root for sexual enhancement
Passion Rx is Bestseller

How quickly does Passion Rx work?
Passion Rx provides results that are often seen within two to four days, but continue to improve with use. Our feedback thus far indicates more than 85% user satisfaction. Dr. Sahelian and his research staff have tested various doses and extracts of dozens of herbs from a number or raw material suppliers to determine the ideal dosage and combination for optimal aphrodisiac properties with the fewest side effects. After years of trial and error, a unique proprietary blend with more than a dozen herbal extracts from the best raw material suppliers has been created. The exact dosage and herbal extract potencies of this effective aphrodisiac blend is a close kept secret only known to the doctor and his research staff. You will only find this exact combination in Passion Rx.

Click Passion Rx for more information regarding the ingredients, or to purchase
Subscribe to a FREE Supplement Research Update newsletter. Twice a month you will receive a review of several studies on various supplements and natural medicine topics, including rehmannia glutinosa root, and their practical interpretation by Ray Sahelian, M.D.

In recent years science has made breakthroughs in the understanding of sexual dysfunction. But, for hundreds of years, civilizations around the world have known about locally grown herbs that achieve wonderful results with far fewer side effects than prescription drugs.
   Now, renowned physician and herbal expert Dr. Ray Sahelian, M.D., author of Natural Sex Boosters, has discovered a combination of exotic herbs from the Amazon jungle, India, China, Malaysia, and Africa, that support healthy desire and performance, as well as to simply enhance sexual pleasure. Passion Rx provides a natural solution for those looking for an alternative to synthetic drugs.

What's in rehmannia glutinosa herb?
From the extract of dry roots of rehmannia glutimosa, fatty acids, palmitic acid, beta-sitosterol, daucosterol, sulfur cyclic cerebroside, dammelittoside, melittoside, rehmaglitin, alpha-Galactosidase and beta-glucosidase, bis-furan derivatives have been isolated. See a list of Chinese Herbs

Rehmannia for hearing conditions
Rehmannia glutinosa activates intracellular antioxidant enzyme systems in mouse auditory cells.
Am J Chin Med. 2006;34(6):1083-93. Department of Food and Nutrition, Kunsan National University, South Korea.
Steamed roots of rehmannia glutinosa have been traditionally used in Oriental medicine for the treatment of auditory diseases such as tinnitus and hearing loss. To investigate whether the ethanol extract of steamed roots of Rehmannia glutinosa increases activity of antioxidant enzymes and the level of glutathione (GSH), we measured activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR) and GSH level in HEI-OC1 cells after treatment with rehmannia glutinosa. The SOD and CAT activities were significantly increased in the presence of Rehmannia glutinosa compared to the control group. The GPX activity also increased dramatically in response to the treatment with rehmannia glutinosa in a dose-dependent manner.  The level of GSH gradually increased in the presence of rehmannia glutinosa. In the cytotoxicity test, 5-50 microg/ml of rehmannia glutinosa did not show any significant cytotoxicity. These results suggest that the traditional use of rehmannia glutinosa for the treatment of auditory diseases may be explained, in part, by activation of intracellular antioxidant enzyme systems.

Protective effect of Rehmannia glutinosa on the cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals.
J Ethnopharmacol. 2006 Oct 11;107(3):383-8. Epub 2006 Apr 6. Department of Food and Nutrition, Kunsan National University, Kunsan, South Korea.
The steamed root of rehmannia glutinosa has been used in traditional Oriental Medicine for treatment of inner ear diseases, such as tinnitus and hearing loss. In the present study, we showed that the ethanol extract of steamed roots of rehmannia glutinosa protected HEI-OC1 auditory cells from cisplatin cytotoxicity in a dose-dependent fashion.

Rehmannia herb composition
This herb has fatty acids, palmitic acid, beta-sitosterol, daucosterol and sulfur cyclic compounds, along with rehmapicroside, norcarotenoids, 2-formyl-5-hydroxy-methylfurane, the iridoid rehmaglutin D, iridoid glycosides, and phenylethyl alcohol glycosides.

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Rehmannia research
Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells.
World J Gastroenterol. 2006 Jul 28;12(28):4478-84. School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan, China.
To investigate the effect of hot water-extracted Lycium barbarum and Rehmannia glutinosa on cell proliferation and apoptosis in rat and/or human hepatocellular carcinoma (HCC) cells. CONCLUSION: Hot water-extracted crude lycium barbarum and rehmannia glutinosa inhibit proliferation and stimulate p53-mediated apoptosis in HCC cells.

[Effect of radix Rehmanniae preparata on the expression of c-fos and NGF in hippocampi and learning and memory in rats with damaged thalamic arcuate nucleus]
Zhong Yao Cai. 2004 Aug;27(8):589-92.
To study the effect of Radix Rehmanniae Preparata on improving the function of learning and memory.  Rehmannia could improve the function of learning and memory of MSG rats, and its mechanism may by related with the increase of the expression of hippocampal c-fos and NGF.

Effect of Rehmannia glutinosa Libosch extracts on bone metabolism.
Clin Chim Acta. 2003 Aug;334(1-2):185-95.
Rehmannia glutinosa Libosch extracts were investigated to determine if they play roles in bone metabolism. Rehmannia stimulates the proliferation and activities of osteoblasts, while inhibiting the generation and resorptive activities of osteoclasts. It also shows preventive effects on osteoporotic bone loss induced by an ovariectomy. Although the active substances have not yet been identified, it is believed that rehmannia seems to contain active components that have a potential to enhance the bone metabolism in osteoporosis.

Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells.
J Ethnopharmacol. 2002 Nov;83(1-2):153-9.
The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of prostaglandin E(2) production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as Aristolochia debilis, Cinnamomum cassia, Cinnamomum loureirii, Curcuma zedoaria, Eugenia caryophyllata, Pterocarpus santalius, Rehmannia glutinosa and Tribulus terrestris showed potent inhibition of COX-2 activity (>80% inhibition at the test concentration of 10 micro g/ml). In addition, the extracts of A. debilis, Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 micro g/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents.

Rehmannia supplement questions
Q. I have been diagnosed with cochlear Meniere's and am not sure which product I should be taking. I read about the rehmannia for hearing conditions and the rehmannia glutinosa that activates. Does it matter which one I take? Rehmannia Endurance or Passion Rx? Would one be better than the other for my condition??
   A. Passion Rx is recommended for sexual enhancement, not hearing problems. We don't have clinical experience with rehmannia, we just listed the study we came across but don't know if it will be effective. You may ask your doctor if it is appropriate for you. Please keep us updated.

Q. Can I use Rehmannia Endurance with Passion Rx or should I just use one of them? I notice that Rehmannia Endurance has 320 mg of rehmannia root. Can you tell me how many mg of rehmannia are in Passion Rx?
   A. We suggest not taking them together. The amount of rehmannia in Passion Rx is small compared to the rehmannia supplement. They are both potent and should not be taken the same day.

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Shu Di Huang rehmannia
Saeng Ji Hwang has a protective effect on adriamycin-induced cytotoxicity in cardiac muscle cells.
Life Sci. 2005 Mar 18;76(18):2027-42. Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk 560-180, Republic of Korea.
This study examined the effect of Saeng Ji Hwang (Radix Rehmanniae) on cardiac muscle cells. Overall, the results suggest that Saeng Ji Hwang -associated Mn-SOD and GSH are important factors in the mechanism of the Saeng Ji Hwang -induced protective mechanism in H9C2 cardiac muscle cells.

This rehmannia herb page was last updated January 2008.