Rice bran oil has been tested on a limited basis and found to potentially have cholesterol lowering properties. More research is needed with rice bran oil to determine whether it has a consistent effect in lowering cholesterol levels. Rice bran oils contains gamma-oryzanol. Another option in keeping cholesterol levels low is to eat less. This can be done quite easily by using 2 or 3 capsules of Diet Rx each day.

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Subscribe to a FREE Supplement Research Update newsletter. Twice a month we email a brief abstract of several studies on various supplements and natural medicine topics, including RICE BRAN OIL, and their practical interpretation by Ray Sahelian, M.D.

Rice Bran Oil and cholesterol Research Update
Use of rice bran oil in patients with hyperlipidaemia.
Natl Med J India. 2005 Nov-Dec;18(6):292-6. St John's National Academy of Health Sciences, Bangalore 560034, Karnataka, India.
The quantity and type of dietary fat is known to affect plasma lipid concentration and hence the choice of cooking oil is important to lower the risk of coronary heart disease. Rice bran oil, which was not popular worldwide, is slowly being recognized as a 'healthy' oil in India. We assessed if rice bran oil had lipid lowering effects in subjects with elevated lipid levels.  The use of rice bran oil as the main cooking oil significantly reduced serum cholesterol and triglyceride levels. The use of rice bran oil together with dietary and lifestyle modifications may have implications for reducing the risk of cardiovascular disease.

Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men*.
Eur J Nutr. 2005 Mar;44(3):163-73.
The cholesterol lowering properties of rice bran oil containing differing amounts of non-saponifiable components have not been studied in humans, to our knowledge. To evaluate cholesterol lowering effects of rice bran oil, with low and high amounts of gamma-oryzanol (ferulated plant sterols) in mildly hypercholesterolemic men. CONCLUSIONS : rice bran oil supplementation at ca. 50% total fat intake improved lipoprotein pattern in mildly hypercholesterolemic men. Methylated sterols in gamma-oryzanol are thought to be largely ineffective at inhibiting dietary cholesterol absorption, but could enhance cholesterol-lowering ability of 4-desmethylsterols. Assuming all ferulated sterols become de-ferulated in the gut, low and high gamma-oryzanol containing rice bran oil provided intestinal loads of 453 and 740 mg/d free 4-desmethylsterols, respectively. This intestinal load of 453-740 mg/d of efficacious free plant sterol equivalents had identical effects on lipoproteins.

Rice bran oil, not fiber, lowers cholesterol in humans.
Am J Clin Nutr. 2005 Jan;81(1):64-8.
Division of Functional Foods Research, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA
The cholesterol-lowering abilities of rice bran's fiber and oil apart from its fatty acid composition remain unclear. The objective of the study was to assess the effects of defatted rice bran and rice bran oil in an average American diet on blood lipids in moderately hypercholesterolemic persons. Twenty-six healthy volunteers consumed a diet with 13-22 g dietary fiber/d for 3 wk, and then 13 of the volunteers were switched to a diet with defatted rice bran to double the fiber intake for 5 wk. Study 2 was a randomized, crossover, 10-wk feeding study performed in 14 volunteers who consumed a diet with rice bran oil (1/3 of the total dietary fat) substituted for an oil blend that had a fatty acid composition similar to that of the rice bran oil. Serum lipids and factor VII were measured in both studies. Defatted rice bran did not lower lipid concentrations. In study 2, total cholesterol was significantly lower with consumption of the diet containing rice bran oil than with consumption of the control diet. Moreover, with consumption of the rice bran oil diet, LDL cholesterol decreased by 7% (P < 0.0004), whereas HDL cholesterol was unchanged. Rice bran oil, not fiber, lowers cholesterol in healthy, moderately hypercholesterolemic adults. There were no substantial differences in the fatty acid composition of the diets; therefore, the reduction of cholesterol was due to other components present in the rice bran oil, such as unsaponifiable compounds.

Increased immune response in mice consuming rice bran oil.
Eur J Nutr. 2005 Feb 22;
Polyunsaturated fatty acids play a key role in a number of biological functions. Rice bran oil is rich in linoleic acid, an essential n-6 fatty acid. n-6 fatty acids are said to have proinflammatory effects as a result of an increase in n-6 fatty acidderived eicosanoids. Rice bran oil is also rich in gamma-oryzanol, a compound from the unsaponifiable fraction, with antioxidant properties. Our results suggest that although gamma-oryzanol may modulate the immune system, it is not responsible for the overall immunostimulation effect seen for Rice bran oil . CONCLUSIONS : Rice bran oil -enriched diets could be useful in situations where a potentiation of the immune response was required. The fatty acids composition, more than the unsaponifiable fraction, might be responsible for this effect.

Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men*
Eur J Nutr. 2004 May 19;:1-11
BACKGROUND. The cholesterol lowering properties of rice bran oil (Rice bran oil) containing differing amounts of non-saponifiable components have not been studied in humans, to our knowledge. AIM OF THE STUDY. To evaluate cholesterol lowering effects of Rice bran oil, with low and high amounts of gamma-oryzanol (ferulated plant sterols) in mildly hypercholesterolemic men. METHODS. Mildly hypercholesterolemic men, 38-64 y, starting cholesterol 4.9-8.4 mmol/l ( n = 30), consumed 50 g/d peanut oil (PNO) in vehicles for 2 wks during a run-in period, then, without wash-out, were randomly equilibrated (based on initial level of cholesterol) into two groups to consume 50 g/d Rice bran oil low (0.05 g/d) or high (0.8 g/d) gamma-oryzanol for 4 wks, in a randomized, controlled, parallel design study. Subjects were free-living and consumed habitual diets with some restrictions. Plasma concentrations of total, LDL-,HDL-cholesterol and triacylglycerol were measured at base line and after 2, 4, and 6 wks. RESULTS. The two Rice bran oil types were not significantly different with respect to effects on various cholesterol parameters, at 2 and 4 wks, including total cholesterol, LDL-, HDL- and LDL/HDL cholesterol ratio. Low and high gamma-oryzanolcontaining Rice bran oil feeding for 4 wks lowered total plasma cholesterol (6.3 %), LDL-C (10.5 %) and the LDL-C/HDL-C ratio (18.9 %). CONCLUSIONS. Rice bran oil supplementation at ca. 50% total fat intake improved lipoprotein pattern in mildly hypercholesterolemic men. Methylated sterols in gamma-oryzanol are thought to be largely ineffective at inhibiting dietary cholesterol absorption, but could enhance cholesterol-lowering ability of 4-desmethylsterols. Assuming all ferulated sterols become de-ferulated in the gut, low and high gamma-oryzanolcontaining Rice bran oils provided intestinal loads of 453 and 740 mg/d free 4-desmethylsterols, respectively. This intestinal load of 453-740 mg/d of efficacious free plant sterol equivalents had identical effects on lipoproteins.

Influence of rice bran oil on serum lipid peroxides and lipids in human subjects.
Indian J Physiol Pharmacol. 2001 Oct;45(4):442-4.
To study the effect of rice bran oil (RBO) on serum lipids and lipid peroxides in human volunteers. Nine healthy volunteers, aged between 42 to 57 years were given 75 ml of RBO thrice daily as the cooking medium with break fast, lunch and dinner for a period of 50 days. At the beginning and at the end of 50 days, 5 ml of blood were drawn from an ante cubital vein. Serum lipids and lipid peroxides levels were estimated from the blood sample. There was a significant decrease in the levels of lipid peroxides, triglycerides, LDL, VLDL, and total cholesterol in human volunteers who switched over to RBO. RBO has evidently antioxidant and antilipidemic activities in human subjects.

Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions.
Phytother Res. 2001 Jun;15(4):277-89.
Diet is the first (and sometimes the only) therapeutic approach to hyperlipoproteinaemias. Rice bran oil and its main components (unsaturated fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol) have demonstrated an ability to improve the plasma lipid pattern of rodents, rabbits, non-human primates and humans, reducing total plasma cholesterol and triglyceride concentration and increasing the high density lipoprotein cholesterol level. Other potential properties of rice bran oil and gamma-oryzanol, studied both in vitro and in animal models, include modulation of pituitary secretion, inhibition of gastric acid secretion, antioxidant action and inhibition of platelet aggregation.