Rutaecarpine health benefit by Ray Sahelian, M.D.
March 1 2016

Rutaecarpine is an alkaloid found in certain herbs including Evodia rutaecarpa, a well-known Chinese herb called Wu-Chu-Yu. Herbal formulations based on Wu-Chu-Yu have been widely used in China for centuries. Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has blood thinning, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity.

Rutaecarpine health benefit
Laboratory and early animal studies indicated rutaecarpine to have anticancer, anti-inflammatory, analgesic, anti-obesity and blood thinning properties. Rutaecarpine has been used in China to treat gastrointestinal disorders, dysmenorrhea, and hypertension.

Eur J Pharmacol. 2015. Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1. Gap junctions, which is formed by connexins, has been proved to play an important role in the atherogenesis development. Rutaecarpine was reported to inhibited monocyte migration, which indicates its potential for anti-atherosclerosis activity. . Results suggest that rutaecarpine has the potential for use as an anti-atherosclerosis agent with a novel mechanism.

Chin J Integr Med. 2013. Rutaecarpine inhibits angiotensin II-induced proliferation in rat vascular smooth muscle cells.

Rutaecarpine mechanism of action
The reported biological effects of rutaecarpine include diuresis, perspiration, uterotonic action, improvement in cerebral functions, and vasorelaxation.

sometimes spelled as rutacarpine.