Schisandra berry supplement by Ray Sahelian, M.D. Health benefit of schisandra herb

Extracts from the fruits (seeds) of Schisandra chinensis L. are one of the components of medicinal preparations designed for the treatment of cardiovascular diseases, liver diseases, diseases of the central nervous system related to the old age, as a supplement in the treatment of neoplasms, diabetes, etc. Schisandra extracts are also used for the production of nutraceuticals (soft drinks and health foods), preparations for oral hygiene and for the care for the skin and hair. See Chinese Herbs of list of herbs used in Chinese Medicine.

Schisandra Extract 10:1, 250 mg
Paradise Herbs

Paradise Herbs Schisandra is naturally extracted using only the finest quality Fructus Schisandra chinesis. Our Standardized True Spectrum extract provides active levels of schisandrins, concentrated in the balanced ratio nature intended, without isolating, fractionizing or using toxic solvents, harsh chemicals or gases.

Schisandra is a famous tonic traditionally used by both royalty and master herbalists. It is one of the few herbs that contain the three treasures known as Jing, Qi and Shen. Traditionally used for enhancing the energy of the kidney and liver, Schisandra is known for supporting memory and sexual endurance. It is mildly calming and helps strengthen the primary energies of life. As a tonic it supports radiant beauty and overall vitality.**

Schisandra Supplement Facts
Amount Per Serving
Schisandra chinesis fruit extract 10:1 - 250 mg
   (Equivalent 2,500 mg)
   9% Schisandrins - 22 mg

Suggested Use: 1
Schisandra capsule daily or as directed by a qualified healthcare professional

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Subscribe to a FREE Supplement Research Update newsletter. Twice a month you will receive an email with a review of several studies on various supplements and natural medicine topics, including schisandra berry health benefit studies, and their practical interpretation by Ray Sahelian, M.D.

Mind Power Rx - Formulated by Ray Sahelian, M.D.

Mind Power Rx is a sophisticated cognitive formula. It combines a delicate balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support:

Memory and Mood
• Mental clarity
• Concentration 
• Alertness and Focus


Why buy all the individual herbs and nutrients separately -- at great expense -- when you can buy this excellent combination?

The herbs in Mind Power Rx include: Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba, Ginseng, Mucuna pruriens, and Reishi.  The nutrients and vitamins in Mind Power Rx include
Acetyl-l-Carnitine, Carnitine, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine. Mind-Power-Rx does not have schisandra extract.

About schisandra herb
Schisandra (Schisandra chinensis) is an aromatic, woody vine that is native to northern and northeastern China . Schisandra fruit is fully ripened in the fall and appears as numerous spikes of tiny, bright red berries. The berries have sweet, sour, hot, salty, and bitter tastes -- hence the Chinese name for schisandra, "Wu Wei Zi" (five-flavored herb).
   Schisandra chinensis, originally a Japanese-Manchurian endemite, yields a vegetable drug (Schisandrae fructus) with a number of very utilizable therapeutic effects. Studies indicate schisandra has hepatoprotective, adaptogenic, and antioxidative capabilities. It is obvious that a very positive therapeutic effect based on the use of a complex mixture of schisandra's principal constituents because their biological effects are complementary and potentiate each other. At the same time, some lignans (e.g. gomisin A, gomisin N) are interesting as new prospective medicines.

Components of Schisandra
Some of the active ingredients in schisandra include
dibenzocyclooctadiene lignans, schizandrin, wuweizisu A, B, C;wuweizichun A, B; wuweizi ester and schisanhenol. A variety of active constituents including acids, phytosterols (beta-sitosterol and stigmasterol), ivtamins C and E, volatile oils and at least 30 different lignans (deoxyschizandrin, gomisins, pregomisin, schizandrin, and others), have been isolated from schisandra.

Properties of Schisandra
Antioxidant and liver protection
Schisandrin B (Sch B), an active ingredient of the fruit of Schisandra chinensis, enhances the hepatic glutathione antioxidant system in mice, as evidenced by the hepatoprotection against carbon tetrachloride (CCl4) toxicity. The mechanism of hepatoprotection afforded by Sch B treatment may involve the enhancement of mitochondrial glutathione redox status.

Protection of brain cells
Dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxins.

Schisandra Research studies
Identification and Characterization of Potent CYP3A4 Inhibitors in Schisandra Fruit Extract.
Drug Metab Dispos. 2004 Sep 1
Schisandra fruit, a Schisandraceae family herb, is used as a component in Kampo medicines (developed from Chinese medicines, but established in Japan). It can act as a sedative and antitussive, improve hepatic function, and give a general tonic effect. An extract of Schisandra fruit has been shown with a potent inhibitory effect on human liver microsomal erythromycin N-demethylation activity mediated by cytochrome P450 3A4 (CYP3A4). The present study was conducted to identify Schisandra fruit components having inhibitory effects on CYP3A4 by surveying the effect on human liver microsomal erythromycin N-demethylation activity. Known components of Schisandra fruit, gomisins B, C, G, and N and gamma-shizandrin, showed inhibitory effects on N-demethylation activity. Among these components, gomisin C displayed the most potent and competitive inhibitory effect. These results indicate that gomisin C is a mechanism-based inhibitor that not only competitively inhibits but irreversibly inactivates CYP3A4.

Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schisandra chinensis.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Apr 25;770(1-2):283-9.
Six major lignans (schizandrin, gomisin A, deoxyschizandrin, y-schizandrin, gomisin N, wuweizisu C) in the caulomas and leaves of Schisandra chinensis (Turcz.) Baill., and cinnamic acid in the leaves of the plant, were quantitatively analysed by high-performance liquid chromatography in reversed-phase mode with UV detection.

Schisandra supplement emails
Q. I am researching taking schisandra, and see that it increases estrogen receptivity. This sounds like something to be avoided if one has had type breast cancer; whether or not cells were found to be estrogen-receptive. Yet, I see no warnings in the literature. Would you please comment.
     A. It's really difficult to make any firm statements regarding the long term effect of an herb on the human body based on a laboratory study of what an herb does to specific cells to what it would do in humans after digestions, absorption, and modification. Herbs considered Phytoestrogens may have some estrogen-like activity, but in a subtle and usually non-harmful, non tumor-stimulating way.

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Schisandra Extract 9% Schisandrins