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What's in Shilajit? How does
A number of chemicals are found including minerals, benzopyrones, and fulvic acids. Its
Am J Mens Health. 2013. Parasympathomimetic effect of shilajit accounts for relaxation of rat corpus cavernosum. The peripheral parasympathomimetic effects of shilajit were confirmed by blockade of shilajit-induced relaxations (in vitro) and shilajit-induced lowering of mean arterial blood pressure and heart rate (in vivo) by atropine.
Arch Med Res. 2012 Nov. Can nutraceuticals prevent Alzheimer's disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins. Studies suggest that shilajit and its active principle fulvic acid, as well as a formula of shilajit with B complex vitamins, emerge as novel nutraceutical with potential uses against this brain disorder.
A novel idea of the composition and source of Shilajit
Q. Dear Dr. Sahelian, Since writing to you from Islamabad (consulting geologist in Pakistan) a couple of years ago I have continued to explore Salajit origins and have collected some 20 kgs of raw material from several sites in the NWFP of Pakistan. I am now semi-retired and will dedicate more time to writing up an article perhaps for Nature or some similar magazine or journal. Without exception all published material I have collected was based on samples bought on the street / market and not collected from source. My studies of the process chain shows laboratory samples are likely to be contaminated since the raw material is mixed with rock dust (to increase sales weight) and additives such as honey and apricot juice to sweeten the taste. My raw material was collected from the rock outcrops and thin section petrology shows it it is not an exudate but merely a surface deposit. Chromatography shows it to be of waxy organic origin. I have observed and recorded the surrounding flora and fauna and have concluded the deposit is excreta mixed with urine from mammals including the Afghanistan Pika and the Giant Wooly Flying Squirrel. Since the habitat of these creatures is limited, and the distribution of various forms of salajit more widespread, I can only conclude that other mammals also contribute to the source. The sites are needless to say spectacular... being rocky ledges on cliffs and steep hill slopes at high altitude. On average it took me 2-3 days to get in and out from each site guided by local hunters. I have developed a 90 minute lecture which I have presented to scientific gatherings in Islamabad and my home town Melbourne and everyone agrees the story should make a fine National Geographic type documentary. Accordingly I am seeking organisations that may jointly sponsor such an expedition / project. The topic covers geology (my specialty of course) medicine, biology, botany, human sociology and conservation as these mammals are an endangered species being adversely affected by both Salajit hunters and deforestation. Would you please give your consideration to the potential role you could provide in such a project and I look forward to hearing from you soon. Yours Sincerely, Dr George Carman.
A. This is very interesting. However, I am not closely enough involved in this area to find the time for it but I will post your email on my shilajit web page in case others come across my website and wish to contact you.
Q. I am a consultant geologist in the oil and gas industry and whilst working in Pakistan, came to hear of Salajit (as it is spelt in Urdu) . Also known as Shilajit and Shilajeet. Your webpage suggests shilajit is an exudate of the plant Styrax officinalis Linn with important mineral constituents related to the bedrock. In contrast some vendor websites (particularly Indian ones) state it is a juice of the rocks, an exudates form the rock itself. Would you be please be so kind and to point me to some research on the origins of shilajit particularly any that clearly confirms that is formed by the plant Styrax officinalis lin.
A. I, too, have had difficulty finding out exactly where shilajit comes from, and I can't seem to find a definitive answer, I get different responses from different raw material suppliers when I ask them about the source of the shilajit. So, I am still searching ourselves for the right answer.
Cardiovasc Toxicol. Jan 22 2014. Cardioprotective Effect of Mumie (Shilajit) on Experimentally Induced Myocardial Injury. This study assessed the effects of mumie (shilajit) pre-treatment, a traditional drug which is well known in the ancient medicine of both east and west, on cardiac performance of rats subjected to myocardial injury. Animals were divided into control, M250, and M500 (received mumie at dosages of 250 and 500 mg/kg/day, orally for 7 days, respectively) main groups each consisting of two subgroups-with and without heart injury. On the 6th and 7th days, isoproterenol (ISO) (85 mg/kg i.p.) was injected (s.c.) to half of the animal subgroups to induce myocardial damage. On the 8th day, after hemodynamic parameter recordings, hearts were removed for further evaluation. Mumie pre-treatment had no significant effects on hemodynamic and cardiac indices of normal animals. When the cardiac injury was induced, mumie maintained the Īdp/dt maximum, attenuated the serum cardiac troponin I, and reduced the severity of cardiac lesions. Despite the mild positive effects of mumie on total antioxidant capacity and lipid proxidation index, no significant difference was observed among animal groups. The findings suggest the prominent cardioprotective effect of mumie against destructive effects of ISO. It seems that other mechanisms than reinforcements of antioxidant system are involved in this beneficial effect.
Shilajit and sperm health and for improving fertility
Effects of Shilajit on the development of tolerance to morphine in mice.
Phytother Res. 2001.
Effects of concomitant administration of Processed Shilajit in Swiss mice were evaluated on the development of tolerance to morphine induced analgesia in the hot plate test. Chronic administration of morphine to mice over a duration of 10 days resulted in the development of tolerance to the analgesic effect of morphine. Concomitant administration of Shilajit with morphine, from day 6 to day 10, resulted in a significant inhibition of the development of tolerance to morphine induced analgesia. Processed Shilajit per se, in the doses used, did not elicit any significant analgesia in mice; nor did the chronic concomitant administration of Processed Shilajit alter the morphine-induced analgesia. These findings with Processed Shilajit indicate its potential as a prospective modifier of analgesic tolerance to morphine.
Systemic administration of defined extracts from Withania somnifera and
Shilajit differentially affects cholinergic but not glutamatergic and
markers in rat brain.
Neurochem Int. 1997.
Sitoindosides VII-X, and withaferin-A, isolated from aqueous methanol extract from the roots of cultivated varieties of Withania somnifera, as well as Shilajit, a pale-brown to blackish brown exudation from steep rocks of the Himalaya mountain, are used in Indian medicine to attenuate cerebral functional deficits, including amnesia, in geriatric patients. The present investigation was conducted to assess whether the memory-enhancing effects of these two plant extracts are owing to neurochemical alterations of specific transmitter systems. Administration of Shilajit led to reduced acetylcholinesterase staining, restricted to the basal forebrain nuclei including medial septum and the vertical limb of the diagonal band. Systemic application of the defined extract from Withania somnifera, however, led to differential effects on AChE activity in basal forebrain nuclei: slightly enhanced AChE activity was found in the lateral septum and globus pallidus, whereas in the vertical diagonal band AChE activity was reduced following treatment with sitoindosides VII-X and withaferin-A. Treatment with Shilajit or the defined extract from Withania somnifera affected neither GABAA and benzodiazepine receptor binding nor NMDA and AMPA glutamate receptor subtypes in any of the cortical or subcortical regions studied. The data suggest that Shilajit and the defined extract from Withania somnifera affect preferentially events in the cortical and basal forebrain cholinergic signal transduction cascade. The drug-induced increase in cortical muscarinic acetylcholine receptor capacity might partly explain the cognition-enhancing and memory-improving effects of extracts from Withania somnifera observed in animals and humans.
Antiulcerogenic and antiinflammatory studies with shilajit.
In folk medicine, shilajit has been used to treat diverse clinical conditions ranging from peptic ulcer to bone healing. The present study was conducted to evaluate the possible antiulcerogenic and antiinflammatory activities of shilajit obtained from the rocky mountains of Zarlek, Badekshan, Afghanistan. Shilajit increased the carbohydrate/protein ratio and decreased gastric ulcer index, indicating an increased mucus barrier. Shilajit was found to have significant antiinflammatory effect in carrageenan-induced acute pedal oedema, granuloma pouch and adjuvant-induced arthritis in rats. The results of the present study thus substantiate its use in peptic ulcer and inflammation.
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I asked a trustworthy associate from India to bring some shilajit for me from
India on his return visit to the US. It resembles a bunch of sticky, black
stones. How do I make the best use of this? How am I to consume or determine how
to measure a reasonable quantity? I do not know the proper procedure to slice,
shave or measure. What tools are used or do I melt into a liquid? I am asking
for advice to utilize the substance, since I am unfamiliar with the processes
used to reduce the gummy stones into a consumable portion.
I am familiar with the powder form but not the form in stones. Different shilajit preparations have different potencies so it is difficult to give dosage guidelines.
Also known as Mumio or Mumijo.