Simethicone by Ray Sahelian, M.D.
March 4 2016

Simethicone is a combination of silica gel and polydimethylisiloxane.

Forms of simethicone
You can find it as 100 percent pure simethicone or as simethicone granular 30 percent, which is made of 30 percent simethicone and 79 percent maltodextrin.

Simethicone side effects, risk, adverse reactions
Simethicone side effects include constipation, bloating, and heartburn.

Where is it found?
Simethicone is found in Maalox, Mylanta, and Gas-x.

J Gastroenterol Hepatol. December 2013. Efficacy of simethicone and N-acetylcysteine as premedication in improving visibility during upper endoscopy. Simethicone and N-acetylcysteine have been widely used in improving endoscopic visibility. However, the optimal dose, volume, and dosing time for the premedication regimen are still unclear.AIM:Our aim was to assess the efficacy of premedication in improving endoscopic visibility and determine the contributions of dose, volume, and premedication time. Methods: A total of 1,849 patients were prospectively treated in three groups: group A: 100-mg simethicone suspension in 5 mL water; group B: 100-mg simethicone suspension in 100 mL water; and group C: 100-mg simethicone suspension in 100 mL water containing 200 mg N-acetylcysteine. Mucosa visibility was assessed at seven sites of upper gastrointestinal tract. The sum of scores was considered as total mucosal visibility score (TMVS). The upper body of stomach had the worst visibility score for all groups. TMVS of groups B and C were significantly lower than those of group A. Group C had a significantly fewer patients requiring endoscopic flushing than groups A and B. The TMVS for groups B and C were significantly lower than for group A within 30 minutes of beginning premedication. Beyond 30 minutes of premedication, there were no significant difference in the TMVS among groups. Premedication using 100 mg simethicone in 100 mL of water improves endoscopic visibility. Addition of N-acetylcysteine in 100 mL of water reduces the need for endoscopic flushing.

J Pediatr Gastroenterol Nutr. 2015. Effect of magnesium alginate plus simethicone on gastroesophageal reflux in infants. Gastroesophageal reflux (GER) is a frequently occurring condition in infants capable of causing distressing symptoms. The aim of our study is to evaluate the efficacy of Mg alginate plus simethicone (Gastrotuss Baby, DMG Italia SRL, Pomezia, Italy), compared with rice-starch-thickened formula or with reassurance alone, in the treatment of GER in infants. Mg alginate plus simethicone seems to be more efficacious on GER symptom scores than thickened formula and reassurance with lifestyle changes alone.