Sytrinol cholesterol supplement, health benefit and review of benefits and side effects by Ray Sahelian, M.D.
February 25 2014

Scientists have discovered compounds in oranges, tangerines and palm fruit extracts that support heart health the natural way. More than a decade of research have demonstrated that components found in Sytrinol promotes healthy total cholesterol, LDL cholesterol and triglyceride levels.

Sytrinol has polymethoxylated flavones (PMFs) that decrease apoprotein B, a structural protein needed for endogenous synthesis of LDL cholesterol. PMFs (tangeritin and nobiletin) decrease diacylglycerol acetyl transferase, a liver enzyme needed for endogenous synthesis of triblycerides. More human studies are needed with Sytrinol to determine if this product is a helpful addition to healthy cholesterol management. A search in 2014 did not reveal any new ones published in recent months.

buy Sytrinol, 150 mg, 60 tablets 
Source Naturals


Sytrinol is part of the Cholesterol Rescue family of products and may help to maintain cholesterol levels that are already within the normal range. Contrary to popular belief, the amount of cholesterol produced by the liver is much more significant to total cholesterol levels than cholesterol consumed from dietary sources. Preliminary clinical research shows that it may assist in maintaining a balanced production of cholesterol by the liver.

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Amount Per 1 tablet:
Calcium 35 mg 4%
Sytrinol - 150 mg
    (Proprietary blend of citrus polymethoxylated flavones and palm tocotrienols)

Suggested Use: 1 Sytrinol tablet once or twice daily, or as recommended by your health care professional.

Suitable for vegetarians and HYPOALLERGENIC: contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance. SYTRINOL is a trademark of KGK Synergize exclusively licensed worldwide to SourceOne Global Partners.

Research
I could not find any studies that have tested Sytrinol itself as of February 2014, but there are studies evaluating the role of PMFs (see below). Sytrinol hasn’t been tested well enough to determine how well it works.

Sytrinol side effects, safety, reports from users
I have been taking Sytrinol for 6 months. After the first 3 months, it brought my cholesterol down from 222 to 183. I am going tomorrow for another test to see if it is still lowering it or not. I have a question. Are there any side effects to Sytrinol?
    Thus far we have not had reports of significant side effects with Sytrinol, however sometimes it takes many months or years for a supplement, or medicine, to be sold to the public before we have a better understanding of the potential adverse effects with long term use.

I began taking Sytrinol 150 mg caps 2x a day. (One in morning and one in evening). After 4 weeks, I began to suffer diarrhea. This has continued unrelenting until a visit with a specialist who asked if I had begun taking any new medications or supplements. I have since stopped Sytrinol and added a powerful probiotic into my daily diet. My condition continued to improve and I'm hoping I will return to normal soon. I am 70 years old and do not take medications for any health risk factors.

Please be advised I had a negative reaction to Sytrinol in the form of nervousness and bad dreams. These side effects stopped after I discontinued taking the supplement.

Research study
Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia.
Formulations containing citrus polymethoxylated flavones (PMFs), mainly tangeritin, or citrus flavanone glucosides, hesperidin and naringin, were evaluated for cholesterol-lowering potential in hamsters with diet-induced hypercholesterolemia. PMF metabolites were also investigated. Diets containing 1% PMFs significantly reduced serum total and very low-density lipoprotein (VLDL) + LDL cholesterol (by 19-27 and 32-40%, respectively) and either reduced or tended to reduce serum triacylglycerols. Comparable reductions were achieved by feeding a 3% mixture of hesperidin and naringin, implying lower hypolipidemic potency of the hesperidin/naringin vs PMFs. HPLC-MS analysis identified high serum, liver, and urine concentrations of tangeretin metabolites including dihydroxytrimethoxyflavone and monohydroxytetramethoxyflavone glucuronides and aglycones. Total liver concentrations of tangeretin derivatives corresponded to hypolipidemic concentrations of intact tangeretin in earlier experiments in vitro. This suggests that PMFs are novel flavonoids with cholesterol- and triacylglycerol-lowering potential and that elevated levels of PMF metabolites in the liver might be directly responsible for their hypolipidemic effects in vivo.

Antiproliferative activities of citrus flavonoids against six human cancer cell lines.
J Agric Food Chem. 2002.
Citrus fruits contain high concentrations of several classes of phenols, including numerous hydroxycinnamates, flavonoid glycosides, and polymethoxylated flavones. The latter group of compounds occurs without glycosidic linkages and has been shown to inhibit the proliferation of a number of cancer cell lines. This antiproliferative property was further demonstrated against additional human cancer cell lines, and the antiproliferative actions of a series of synthetic methoxylated flavones were also studied. Similar to the naturally occurring compounds, the synthetic compounds exhibited strong antiproliferative activities. In many cases the IC(50) values occurred below 10 microm. Other hydroxylated flavone and flavanone aglycons also exhibited antiproliferative activities against the cancer cell lines, with the flavones showing greater activities than the flavanones. Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans.

Marketing
Sytrinol is marketed by SourceOne, this is a patented proprietary formula derived from natural citrus and palm fruit extracts. Sytrinol combines citrus polymethoxylated flavones (PMFs) and palm tocotrienols and other proprietary constituents.

In an effort to educate health-conscious consumers about the many benefits of Sytrinol, SourceOne Global Partners has launched an aggressive marketing campaign and consumer awareness program in a number of media outlets such as television, radio, and print. For example, SourceOne produced a video that has aired throughout February 2006 on “Today’s Health,” hosted by Chris Evert. The nationally syndicated show is on ABC, CBS, MSNBC and FOX affiliates. It is also broadcast by the Dish Network satellite on Turner Media Group’s Healthy Living Channel. Furthermore, a 60-second radio news story featuring Sytrinol™ has been produced and broadcast as part of the 30-minute syndicated radio program, “Radio Health Journal” (RHJ). RHJ is broadcast on over 400 stations nationwide. Also, Sytrinol will be featured on multiple health topic programs such as Health Quest Radio.

2008
KGK Synergize Inc., a product development and contract research organization, announced that in accordance with the terms of a binding agreement entered into in December, 2007, the global distribution rights to Sytrinol will return to its inventor and patent holder, KGK of London, Ontario, as of January, 2009. Beginning in 2009, Sytrinol will is available directly through KGK.

Emails and questions
I wonder if Sytrinol can be combined with other supplements such as policosanol? Are there any contraindications with supplements or medications that the consumer should be aware of?
   It is very difficult to predict what will happen when Sytrinol and policosanol are combined. There is hardly any research on the individual supplements, let alone the combination. Add to this factor the individual variation in response, additional medicines a person may be taking, the quality of the supplements, timing of intake, diet of the person, etc, and this all makes it so difficult to predict. A good option is to try one supplement, such as sytrinol, for a few weeks to see how it works, and then add a second one for a few weeks to see if there are additional benefits.

My husband is interested in taking Inno-Vite Sytrinol to lower cholesterol, but he is also taking Verapamil. The latter is not to be taken with grapefruit or grapefruit drink. The ingredient label also includes hespertin, hesperitin and citrus fiber. Should we be concerned about the source of the citrus fiber? To the best of your knowledge, do you know of any interaction of Sytrinol with any medications, including Coumadin?
   This is so difficult to say since I have not seen studies testing these drugs in combination with Sytrinol. Plus, much may depend on dosages and each person's unique absorption and metabolizing processes.

Do you know if eating grapefruit with it is OK?
   We can't see any problems that would arise eating grapefruit with Sytrinol.

Q. I started Sytrinol during middle of May, 2007. The last ALT & AST were done in April,2007. Results were ALT-22, AST - 30. (highest normal=40, as you know). I was taking 2 daily, 150 mg each. I used two different brands, switched from one to another. Loose bowels started on 8/25, as they had with CHOLESTIN AND GUGGUL some years ago. When I stopped them, the symptoms disappeared, even though a G I doctor had diagnosed me with IBS, which I knew I didn't have. I made the dx of the drug, and was correct. Now on 8/25, the bowel symptoms began, not exactly diarrhea, but very loose. Tiny with flecks. Still have it. A week later, on 8/31, I went to my internist and asked for liver enzyme tests, which I got that day. I got the results the next day and the ALT was 152, and the AST was 90. I had stopped the Sytrinol on Monday 8/27, had the test on 8/31. I called the doctor 9/1 with the results which I obtained from the lab. He said to stop the Sytrinol (which I already had done) and get a repeat test in 3 weeks. I am waiting for the time to get the next test. Today, 9/6, my bowels are still loose, and, frankly, I don't dare pass gas. Just waiting. Oh, I am 80 years old. Thought I would let you know. Cardiologist said that 0.5% of people who take statins get elevated liver enzymes. I am exquisitely sensitive to medicines. While I realize that this is not a statin, the word liver is mentioned on the bottle. I an only attribute this problem to Sytinol based on my previous tests, and am writing to inform you of this. I certainly hope the enzymes go down. The bowel problems have resolved in the past with the other products, and I am hoping that they will this time, but it did not happen right away. It took time to improve. Couple of months.
   A. Thanks for sharing this potential Sytrinol side effect with us. This is the first we have heard of a relationship between Sytrinol and liver enzyme elevation. We can't tell at this point if it was the Sytrinol or something else that caused it coincidentally or something unusual about your metabolism. One way to find out is if the liver enzymes return to normal after stopping it and whether they become elevated again after resuming the supplement.
      Q. As I wrote you before, my ALT and AST were high and I attribute it to the the natural medicine. Started it mid -May, Bowel changes started August 15. Last Sytrinol August 27 (2007). Blood tests pf 9/1/07 showed ALT 158 & AST 90. New blood tests of 9/20/07 showed reduction as follows: ALT 40 & AST 33, now higher normals than 4/30 when ALT was 22 and AST 30. This is for your information, since you wrote me that there had been no other complaints. There is not the slightest doubt in my mind that this was caused by the Sytrinol pills.

I have CNS vasculitis and take methotrexate to suppress my immune system. Can I take Sytrinol to lower cholesterol? They said not to mix methotrexate with grapefruit.
   I have not seen any studies or reports regarding the interactions of methotrexate with Sytrinol, so I don't know.

I have been using cholystyramine for about 5 years now to control bile salts. I had my gall bladder removed and without the cholestyramine I get daily diarrhea. Since having my gall bladder removed my tryglyceride and cholesterol levels have greatly increased and a friend recommended Sytrinol. Do you see any problems with taking cholestyramine and Sytrinol together?
   I have not seen studies with the combination of this medication and Sytrinol so it is not easy to give an answer regarding the safety of this combination.

I have a 19 year old son who is a cross-country runner at the university he attends. His BMI was measured at 9% and he runs about 10 miles a day, plus pool workouts. He eats extremely healthy for a teenager avoiding cola drinks, high sugar deserts or candy, and a limited amount of red meat. He just came home from his first away at college and needed a physical for the school. We got his results back and see that his cholesterol level was at 285 on May 19 so he another the blood work on May 30 with a result level of 260. How can this be and would Sytrinol be something he should take to help lower his cholesterol levels.
    Sometimes there is a genetic component to high cholesterol levels and his doctor can test this. It is difficult to predict whether a particular supplement would help, but paying even more attention to diet could be helpful.

I monitor my lipid profile regularly with a standing lab order every 6 weeks. My Total Cholesterol 6 weeks ago was 197 with a 59 HDL. I started taking Sytrinol 5 weeks ago twice a day, kept everything else the same, and went in for another lab test this week. My total Cholesterol went up to 229 but my HDL increased 24% to 73 ! This was a surprise to me as I thought the effect of Sytrinol was to lower LDL substantially and increase HDH minimally. I got increases across the board, but more so in HDL than LDL.
    There are normal daily fluctuations in cholesterol levels based on food intake and a number of other factors. Measuring two separate levels of cholesterol is not enough to make a statistical analysis. Several cholesterol levels need to be checked over a period of several months to have a good understanding of the overall trend.

Would Sytrinol help lower cholesterol levels that are in the total of 7.29? And if so, what product would you recommend?
   It is difficult to predict in any one individual which product or combination will be of help.