therapy for ulcer relief
There are many herbs, nutrients, and plant products that have been found to play a role in protecting or helping to heal stomach and peptic ulcers. Few human trials are available, but many have show good potential in animal or in vitro studies. You may consider ginger for nausea. Here are a few to look into. Before you start a supplement program discuss with your health care provider to make sure you have no serious bleeding issues with the ulcer and to make sure the supplements won't interfere with any prescription medicines you may be taking. I want to emphasize that research with these supplements is very new and limited and there is no definite proof yet that they are effective or should replace the meds you are being prescribed.
Probiotics such as
those found in yogurt probiotics
are friendly bacteria such as Acidophilus, Lactobacillus and Bifidobacterium.
Aloe vera herb may help with gastric ulcer healing.
Artichoke leaf extract has been tested in rodents as a beneficial supplement to reduce gastritis.
Prickly pear fruit, also known as cactus pear, grows on nopal or cactus leaf.
Amla is used in Ayurvedic medicine. You can find amla research below on its influence on ulcer.
Asparagus extract has been studied for ulcer prevention
Whey protein is available as a powder
Garcinia cambogia may have ulcer healing properties.
Gotu kola (Centella asiatica) has been studied for gastrointestinal symptoms.
Bacopa monniera also works as mental stimulant.
Melatonin or l-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. Three groups (A, B and C) of 14 patients in each treatment group with gastroduodenal chronic ulcers were treated with omeprazole (20 mg twice daily) combined either with placebo (group A), melatonin (group B) or with Trp (group C). On day 7, omeprazole by itself (group A) had not healed any ulcers, but four ulcers were healed with omeprazole plus melatonin and two with omeprazole plus tryptophan. At day 21, all ulcers were healed in patients treated with melatonin or Trp, but only 10-12 ulcers were healed in placebo-treated patients. Plasma gastrin level also rose significantly during treatment with omeprazole plus melatonin or Trp, but it was also significantly increased in patients treated with omeprazole plus placebo. Plasma ghrelin levels did not change significantly after treatment with melatonin or Trp, while plasma leptin increased significantly in patients treated with melatonin or Trp but not with placebo. We conclude that melatonin or Trp, when added to omeprazole treatment, accelerates ulcer healing and this likely depends mainly upon the significant increments in plasma melatonin. J Pineal Res. 2011.
Osha root - J Ethnopharmacol. 2015. Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri coulter & rose on ethanol-induced lesions in rats.
Propolis extract is an interesting supplement.
Reishi is a mushroom
Chin J Nat Med. 2013. Antiulcer activity of a polyherbal formulation (PHF) from Indian medicinal plants. The present study was aimed at evaluating the antiulcer activity of the polyherbal formulation (PHF) containing the leaf extracts of Moringa oleifera, Raphinus sativus, and Amaranthus tricolor in rats. The antiulcer activity of the polyherbal formulation (PHF) was evaluated using different models of gastric ulcers: ethanol-induced, indomethacin-induced and ischemia reperfusion-induced gastric ulcers. Efficacy was assessed by determining the ulcer index. Administration of the polyherbal formulation (150 mg·kg(-1), p.o.) offered significant protection against indomethacin-induced, ethanol-induced, and ischemic reperfusion-induced ulcer models when compared to the control group. PHF, containing leaf extracts of Moringa oleifera, Raphinus sativus, and Amaranthus tricolor, was found to possess antiulcer properties in three experimental animal models of gastric ulcers, and these findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity.
Iran J Pharm Res. 2014. Assessment of some Herbal Drugs
for Prophylaxis of Peptic Ulcer.. tAqueous (hydrophilic) and chloroform (Lipophilic)
extracts of nine medicinal plants currently used in Egyptian traditional
medicine to treat some gastrointestinal tract (GIT) disorders were tested for
their gastro-protective effect against the incidence of peptic ulcer.
Indomethacin-induced ulcer in a rat model was used for this testing. Mentha
microphylla, Brassica oleracea Capitata (Cabbage), B. oleracea Botrytis
(cauliflower) aqueous fraction, Portolaca oleracea polysaccharide fraction,
Oreganum marjoranum, Matricaria recutita, Solanum nigrum hydrophilic and
lipophilic fractions, in addition to the chloroform fraction of Portolaca
oleracea and Cicorium intybus afforded high protection against the incidence of
gastric ulcer (~95%). O. syriacum hydrophilic and lipophilic fractions and gum
arabic afforded moderate prophylactic effect. L. sicerarea, C. intybus
hydrophilic fractions and M. microphylla lipophilic fraction were inactive.
Herbs represent excellent resources for cost-effective and readily available
gastro-protective remedies without side effects.
Causes of ulcers - a bug?
Peptic ulcer disease has been considered to be a chronic gastrointestinal illness with low mortality but with frequent flare ups. Up until recently, peptic ulcer disease was thought to be caused by an imbalance between acid and pepsin secretion, and defensive factors such as bicarbonate secretion and gastric mucosal barrier. The isolation of Helicobacter pylori from patients with chronic gastritis and duodenal and gastric ulcers has revolutionized thinking about the causes of peptic ulcer disease. Current data suggest that persistent infection with Helicobacter pylori may account for peptic ulcer disease. Thus, because of the presence of this organism in ulcers, conventional treatment of peptic ulcer disease has to be altered. At the present time, there is no generally accepted, safe and effective therapy for H. pylori infections. Several clinical trials, using antibiotics have claimed some success. Of great clinical importance are the epidemiologic data which show a link of Helicobacter pylori infection to gastric cancer.
Aspirin and Peptic Ulcer
About ten percent of patients taking low-dose aspirin to lower their risk of a heart attack develop peptic ulcers, which frequently cause no symptoms. Aspirin can be of great benefit to those at high risk of heart attack or stroke but the risks as well as the benefits need to be carefully weighed before embarking on its long-term use in people who are at only low cardiovascular risk. It may be best to take a baby aspirin every other day as opposed to a full aspirin daily.
Adults who had a difficult childhood may be at higher risk of developing a stomach ulcer than those with a less stressful past. World Journal of Gastroenterology, July 21, 2009.
Medical Treatment of Ulcers
The traditional medical approach to treating ulcers is with antacids, histamine-2 blockers, and proton pump inhibitors. Cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac) are examples of histamine-2 (H2) blockers. Proton pump inhibitors (PPIs) are one of the most commonly prescribed classes of medications in the primary care setting and are often used in the treatment of acid-peptic diseases. Since the introduction of omeprazole (Prilosec) in 1989, several other PPIs have become available in the United States. Anti-ulcer drugs may increase the risk of certain allergies to foods. PPIs could make it more likely to catch an infection and the use of these ulcer drugs can increase the risk of osteoporosis.
The combination of antibiotics and probiotics is more beneficial in eradicating H. Pylori than antibiotics alone.
Nexium (esomeprazole magnesium, AstraZeneca) Delayed-Release capsules were approved in 2006 by the FDA for use in children ages 12 to 17 for the short-term treatment of gastroesophageal reflux disease (GERD).
Refractory peptic ulcers are ulcers in the stomach or duodenum that do not heal after eight to 12 weeks of medical treatment or those that are associated with complications despite medical treatment. Recurrent peptic ulcers are peptic ulcers that recur after healing of the ulcer. Given the number of deaths due to peptic ulcer-related complications and the long-term complications of medical treatment (increased incidence of fracture), it is unclear whether medical or surgical intervention is the better treatment option in people with recurrent or refractory peptic ulcers.
Drugs May not be Safe
Popular ulcer drugs such as proton-pump inhibitors that block stomach acid production heighten the risk of an increasingly common infectious form of diarrhea. Taking such drugs as AstraZeneca's Nexium and Losec or their generic versions significantly increase the risk of diarrhea blamed on the Clostridium difficile bacteria. Frequently prescribed anti-heartburn drugs called H2 antagonists that include GlaxoSmithKline's Zantac were found to double the risk of the bacterial diarrhea. The drugs reduce gastric acid, allowing for bacteria to multiply in the digestive system. Clostridium is the third-most common type of infectious diarrhea in patients aged 75 and older. Exposure to Clostridium difficile bacteria, which causes infection and inflammation of the intestine, previously occurred mostly during hospital stays, but cases have increasingly been contracted in community settings. While antibiotics formerly blamed for outbreaks of the illness have declined in use, the acid-blocking drugs have become steadily more popular to treat ulcers and conditions such as gastric reflux disease. PPI ulcer drugs, when used for prolonged periods, make bones more brittle.
Since their introduction in 1990, the drugs collectively known as proton pump inhibitors (common brand names: Nexium, Prevacid, Prilosec) have become among the most frequently prescribed in the country; they are also available over the counter. They suppress stomach acid more effectively than a previous class of drugs called H2 blockers (Zantac, Tagamet, Pepcid). In recent years, studies have reported associations between prescription P.P.I. use and an array of health problems, including bone fractures, low magnesium levels, kidney injuries and possibly cardiovascular drug interactions.
Increased risk for kidney disease
People who take popular heartburn pills known as proton pump inhibitors (PPIs) may be more likely to develop chronic kidney disease than individuals who don’t use these drugs. The association is worrisome because tens of millions of people a year take these pills, sold by prescription and over-the-counter in some countries, with brand names including Prilosec, Prevacid and Zegerid.
The most common symptom of peptic ulcers is abdominal pain which can last anywhere from a few minutes to several hours. Ulcer pain is often worse at night and early morning. Pain from ulcers often comes several hours after a meal when the stomach is empty. The pain is usually in the upper middle part of the abdomen, above the belly button (navel) and below the breastbone. An ulcer pain can feel like burning or gnawing, and it may go through to the back. The pain may be relieved by food, antacids, or vomiting.
Drugs that can cause ulcers or
bleeding from the intestinal tract
Selective serotonin reuptake inhibitors (SSRIs) and nonsteroidal anti-inflammatory drugs (NSAIDs), when combined, can interact to increase the risk of upper gastrointestinal bleeding.
A Randomized, Placebo-Controlled Study of the Effects
of Naproxen, Aspirin, Celecoxib, or Clopidogrel on Gastroduodenal Mucosal
Alimentary Pharmacology & Therapeutics 2009.
Many individuals with gastroduodenal ulcers require on-going NSAID or anti-platelet therapy. We evaluated the effects of these agents on gastroduodenal mucosal healing. H pylori-negative volunteers were randomized to receive naproxen, celecoxib, aspirin, clopidogrel, or placebo. Antral and duodenal lesions were created endoscopically with a biopsy forceps. After 7 days of medication dosing, each lesion was scored [from 0 (low) to 8 (high)] using a validated methodology. 108 subjects completed the study. Naproxen impaired antral lesion healing more than placebo, clopidogrel, aspirin, or celecoxib. Naproxen impaired duodenal lesion healing more than placebo, clopidogrel, or aspirin. Naproxen may impair gastroduodenal healing more than aspirin or celecoxib in H pylori negative subjects. Clopidogrel did not impair mucosal healing.
Ulcer Research studies
Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy.
Am J Clin Nutr. 2006 Apr;83(4):864-9.
Department of Internal Medicine, Medical College, National Cheng Kung University Hospital, Tainan Taiwan.
Lactobacillus- and Bifidobacterium-containing yogurt (AB-yogurt) can suppress Helicobacter pylori. Improvement of the eradication rate by quadruple therapy of residual H. pylori after failed triple therapy is needed. We tested whether prior treatment with AB-yogurt improved the efficacy of quadruple therapy in eradicating residual H. pylori after failed triple therapy. One hundred thirty-eight patients in whom triple therapy failed were enrolled for a culture study of H. pylori to assess antimicrobial resistance. These patients were then randomly assigned in equal numbers to either a yogurt-plus-quadruple therapy group or a quadruple therapy-only group. The patients received 1 week of quadruple therapy with or without a 4-wk pretreatment with AB-yogurt (400 mL/d). In the yogurt-plus-quadruple group, The yogurt-plus-quadruple therapy group had a higher H. pylori eradication rate than did the quadruple therapy-only group (intention-to-treat analysis: 85% compared with 71%,. A 4-wk pretreatment with AB-yogurt can decrease H. pylori loads despite antimicrobial resistance, thus improving the efficacy of quadruple therapy in eradicating residual H. pylori.
Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in
subjects with colonized Helicobacter pylori.
Am J Clin Nutr. 2004.
Evidence suggests that ingesting lactic acid bacteria exerts a suppressive effect on Helicobacter pylori infection in both animals and humans. Supplementing with Lactobacillus- and Bifidobacterium-containing yogurt (AB-yogurt) was shown to improve the rates of eradication of H. pylori in humans. We administered AB-yogurt to subjects with asymptomatic H. pylori to test whether the yogurt could inhibit H. pylori growth. The in vitro inhibition of H. pylori growth was determined by inoculating Lactobacillus acidophilus or Bifidobacterium lactis on plates that were inoculated with H. pylori. Regular intake of yogurt containing Bifidobacterium lactis and Lactobacillus acidophilus effectively suppressed H. pylori infection in humans.
Anti- ulcer drugs promote oral sensitization and hypersensitivity to
hazelnut allergens in BALB/c mice and humans.
American Journal of Clinical Nutrition, 2005
Hazelnut allergy can be a consequence of sensitization to cross-reactive pollen, especially from the Fagales family. However, severe allergic reactions after ingestion of hazelnuts without associated pollen allergy have been reported. In these cases, oral sensitization by hazelnut ingestion is plausible. We have reported that anti- ulcer drugs promote oral sensitization to digestion-labile food allergens. Because hazelnut proteins were sensitive to gastric digestion in our in vitro assay, we aimed to analyze the effect of anti- ulcer treatment on oral sensitization to hazelnut proteins. Design: BALB/c mice were fed hazelnut extract with or without ant- iulcer drugs. In parallel, gastroenterologic patients were screened during anti- ulcer treatment for specific immunoglobulin (Ig) E to hazelnut and inhalative allergens in vitro and in vivo. Mice fed hazelnut extract in combination with anti- ulcer drugs formed anaphylactogenic IgG1 toward hazelnut and developed type I skin reactivity to hazelnut extract. In the human study population, 5 of 153 patients developed hazelnut-specific IgE, 4 of 5 developed specific skin reactivity, 3 of 5 had a positive result to oral provocation, and 2 of 5 manifested a food allergy to hazelnut after a 3-mo course of anti- ulcer treatment. Immunoblot testing with recombinant allergens showed that hazelnut, but not Fagales pollen, was the genuine elicitor in mice and humans. Our experimental and epidemiologic data suggest that the intake of anti- ulcer drugs may lead to the induction of immediate-type food hypersensitivity toward hazelnut.
The gastric microbe, Helicobacter pylori, that's the cause of most stomach ulcers also takes it out on the heart. People with rapid beating of the upper chamber of the heart, atrial fibrillation, are nearly 20 times more likely to be infected with Helicobacter than are healthy "controls," according to a report in the medical journal Heart. While the exact mechanism is unknown, the theory is that it may relate to autoantibodies that develop in some H. pylori-infected patients. These antibodies, which normally attack an acid pump found on gastric cells, may instead attack a similar pump on cardiac cells, ultimately triggering atrial fibrillation. The new findings are based on a study of H. pylori tests in 59 patients with atrial fibrillation and 45 healthy controls. In the overall analysis, 97 percent of atrial fibrillation patients were positive for H. pylori compared with just 5 percent of controls.
Inhibition of Helicobacter pylori in vitro by various berry
extracts, with enhanced susceptibility to clarithromycin.
Mol Cell Biochem. 2004.
Department of Pediatrics, Creighton University Health Sciences Center, Omaha, NE
The objective of this study was to evaluate the effects of various berry extracts, with and without clarithromycin on Helicobacter pylori. Resistance to clarithromycin by H. pylori has been reported, leading to interest in alternatives/adjuncts to therapy with clarithromycin. H. pylori American type culture collection (ATCC) strain 49503 was grown, cell suspensions were made in PBS and diluted 10-fold. One hundred microL of the suspension was then incubated for 18 h with extracts of raspberry, strawberry, cranberry, elderberry, blueberry, bilberry, and OptiBerry, a blend of the six berries, at 0.25-1% concentrations. Serially diluted cell suspensions were exposed for 1 h to clarithromycin at 15 microg/ml. Ten microl of bacterial samples from the 10(-7) dilution tube were plated and incubated for 18 h and the number of colonies were counted. Growth of H. pylori was confirmed by the CLO test. All berry extracts significantl inhibited H. pylori, compared with controls, and also increased susceptibility of H. pylori to clarithromycin, with OptiBerry demonstrating maximal effects.
The stomach bug H. pylori is responsible for most ulcers, but it can usually be eradicated with medication. However, many people who undergo this treatment put on weight -- and now Japanese scientist think they know why. Elimination of H. pylori infection leads to a significant increase in levels of the powerful appetite-stimulating hormone ghrelin in the tissues of the stomach where it is produced, the researchers report in the American Journal of Gastroenterology.
Widely used heartburn and ulcer drugs such as Nexium, Pepcid and Prilosec can make people more susceptible to pneumonia, probably because they reduce germ-killing stomach acid, Dutch researchers found in a study of more than 300,000 patients. The highest risks occurred with more powerful acid-fighting drugs called proton pump inhibitors, which are sold in the United States under such brand names as Nexium, Prevacid and Prilosec. Over nearly three years, users of these drugs faced almost double the risk of developing pneumonia compared with former users. Users of another class of acid-fighting drugs that includes cimetidine and famotidine — sold in the United States as Tagamet and Pepcid — also faced an elevated risk.
Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori.
American Journal of Clinical Nutrition, Vol. 80, No. 3, 737-741, September 2004
Evidence suggests that ingesting lactic acid bacteria exerts a suppressive effect on Helicobacter pylori -- a cause of stomach ulcer -- infection in both animals and humans. Supplementing with Lactobacillus- and Bifidobacterium-containing yogurt (AB-yogurt) was shown to improve the rates of eradication of H. pylori in humans. We administered AB-yogurt to subjects with asymptomatic H. pylori to test whether the yogurt could inhibit H. pylori growth. Design: In an intervention study, 59 adult volunteers infected with H. pylori were given AB-yogurt (107 colony-forming units of both La5 and Bb12/mL) twice daily after a meal for 6 wk. Eleven subjects positive for H. pylori infection were treated with milk placebo as control subjects. H. pylori bacterial loads were determined with use of the 13C-urea breath test, which was performed before and 4 and 8 wk after the start of AB-yogurt supplementation. Results: Bb12 exerted an in vitro inhibitory effect against H. pylori, whereas La5 did not show an effect. Administration of AB-yogurt decreased the urease activity of H. pylori after 6 wk of therapy. Conclusion: Regular intake of yogurt containing Bb12 and La5 effectively suppressed H. pylori infection in humans.
The healing effects of Centella extract - gotu kola - and asiaticoside on acetic acid induced gastric ulcers in rats.
Life Sci. 2004 Mar 19;74(18):2237-49.
In this study, the healing effects of gotu kola water extract and asiaticoside, an active constituent of gotu kola, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined. Gotu kola was prepared from Centella asiatica dry plant and the concentration of asiaticoside in gotu kola was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of gotu kola and asiaticoside were orally administered to rats with kissing ulcers. They were found to reduce the size of the ulcers at day 3 and 7 in a dose-dependent manner, with a concomitant attenuation of myeloperoxidase activity at the ulcer tissues. Epithelial cell proliferation and angiogenesis were on the other hand promoted. The expression of basic fibroblast growth factor, an important angiogenic factor, was also upregulated in the ulcer tissues in rats treated with gotu kola or asiaticoside. These results further suggest the potential use of gotu kola and its active ingredient as anti-gastric ulcers drugs.
Antioxidant, antimicrobial, antiulcer and analgesic
activities of nettle (Urtica dioica L.).
Ataturk University, Erzurum, Turkey.
J Ethnopharmacol. 2004.
In this study, water extract of stinging nettle (Urtica dioica L.) was studied for antioxidant, antimicrobial, antiulcer and analgesic properties. The antioxidant properties of stinging nettle were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. Stinging nettle had powerful antioxidant activity. The 50, 100 and 250 microg amounts of stinging nettle showed 39, 66 and 98% inhibition on peroxidation of linoleic acid emulsion, respectively, while 60 microg/ml of alpha-tocopherol, exhibited only 30% inhibition. Moreover, stinging nettle had effective reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities at the same concentrations. In addition, total phenolic compounds in the stinging nettle were determined as pyrocatechol equivalent. Stinging nettle also showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching.
In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and
accumulation of prostaglandins.
Bacopa monniera is an Indian tratidional medicine widely used to improve intellectual functions. Earlier, we had reported the prophylactic and curative effects of standardized extract of Bacopa monniera in various gastric ulcer models. The effect was due to augmentation of the defensive mucosal factors like increase in mucin secretion, life span of mucosal cells and gastric antioxidant effect rather than on the offensive acid-pepsin secretion. The present study includes evaluation of standardized Bacopa monniera extract (bacoside A content--35.5 +/- 0.9) on other contributing factors towards ulcerogenesis. Bacopa monniera in the dose of 1000 microg/ml showed anti-Helicobacter pylori activity in vitrol and in the dose of 10 microg/ml increased in vitro of prostanoids (PGE and PGI2) in human colonic mucosal incubates. It may be concluded that these factors may contribute to antiulcerogenic activity of Bacopa monniera.
The healing effects of Centella extract and asiaticoside on
acetic acid induced gastric ulcers in rats.
Life Sci. 2004.
In this study, the healing effects of Centella asiatica water extract (CE) and asiaticoside (AC), an active constituent of CE, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined. CE was prepared from Centella asiatica dry plant and the concentration of AC in CE was quantitatively determined with the use of high performance liquid chromatography analysis. Different concentrations of CE and AC were orally administered to rats with kissing ulcers. They were found to reduce the size of the ulcers at day 3 and 7 in a dose-dependent manner, with a concomitant attenuation of myeloperoxidase activity at the ulcer tissues. Epithelial cell proliferation and angiogenesis were on the other hand promoted. The expression of basic fibroblast growth factor, an important angiogenic factor, was also upregulated in the ulcer tissues in rats treated with CE or AC. These results further suggest the potential use of Centella asiatica and its active ingredient as anti-gastric ulcers drugs.
Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
Am J Chin Med. 2003.
An ethanolic extract of Parsley, Petroselinum crispum (Mill.) Nym.ex A.W. Hill (Umbelliferae), was tested for its ability to inhibit gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. The extract in doses of 1 and 2 g/kg body weight had a significant antiulcerogenic activity on the models used. Besides, ethanol-induced depleted gastric wall mucus and non-protein sulfhydryl contents were replenished by pretreatment with Parsley extract. Acute toxicity tests showed a large margin of safety for the extract. The phytochemical screening of Parsley leaves revealed the presence of tannins, flavonoids, sterols and/or triterpenes.
Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils.
Biochem Biophys Res Commun. 2003 Oct 24;310(3):715-9.
Since urease of Helicobacter pylori is essential for its colonization, we focused attention on foodstuffs which inhibit the activity of this enzyme. Among plant-derived 77 foodstuff samples tested, some tea and rosemary extracts were found to clearly inhibit H. pylori urease in vitro. In particular, green tea extract (GTE) showed the strongest inhibition of H. pylori urease, with an IC(50) value of 13 microg/ml. Active principles were identified to be catechins, the hydroxyl group of 5(')-position appearing important for urease inhibition. Furthermore, when H. pylori-inoculated Mongolian gerbils were given GTE in drinking water at the concentrations of 500, 1000, and 2000 ppm for 6 weeks, gastritis and the prevalence of H. pylori-infected animals were suppressed in a dose-dependent manner. Since the acquisition by H. pylori of resistance to antibiotics has become a serious problem, tea and tea catechins may be very safe resources to control H. pylori-associated gastroduodenal diseases.
Efficacy of a whey protein concentrate on the inhibition of stomach ulcerative lesions caused by ethanol ingestion.
J Med Food. 2002 Winter;5(4):221-8.
The purpose of this research was to test the ability of a whey protein concentrate (WPC) to inhibit gastric mucosal ulcerative lesions caused by oral administration to rats of absolute ethanol. Acute administration (single doses) of WPC resulted in 41% inhibition of the ulcerative lesion index (ULI), and 73% inhibition was obtained with repetitive doses. In a 10-days subchronic treatment study, the inhibition was 64%, all relative to a saline treatment (negative control). Alkylation of sulfhydryl compounds by subcutaneous injection of N-ethylmaleimide essentially eliminated the WPC protection. Treating the rats with an intraperitoneal injection of butathionine sulfoximine, which inhibits glutathione synthesis, reduced WPC protection to 35% and 52% for single and double doses, respectively. Taken as a whole, the results indicate that WPC does protect gastric mucosa from ethanol damage and that the protection depends on sulfhydryl compounds present in the WPC, including its capacity to stimulate glutathione synthesis.
Effects of sea buckthorn (Hippophae rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats.
Fitoterapia. 2002 Dec;73(7-8):644-50.
Oils from sea buckthorn (Hippophae rhamnoides L.) seeds and berries have traditionally been used in the treatment of disorders of skin and mucosa in China. Compared with the negative control, oral administration of CO(2)-extracted seed and pulp oils, 7.0 ml x kg(-1) x day(-1) significantly reduced ulcer formation in water-immersion (P < 0.05) and reserpine-induced (P < 0.01) models in rats. In addition, administration of the two oils, 3.5 ml x kg(-1) x day(-1), significantly reduced the index of pylorus ligation-induced gastric ulcer (P < 0.05) and sped up the healing process of acetic acid-induced gastric ulcer (P < 0.01). The results suggested that the CO(2)-extracted sea buckthorn seed and pulp oils have both preventive and curative effects against experimental gastric ulcers in rats.
Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat.
Life Sci. 2002 Dec 27;72(6):731-45.
Many cytokines, in particular tumor necrosis factor (TNF)-alpha have been known to play an important role in the pathogenesis of gastric mucosal lesions caused by various factors such as drugs and Helicobacter pylori infection. Our previous studies have shown that the polysaccharide fractions isolated from the fruiting bodies of Ganoderma lucidum (GLPS) prevented indomethacin- and acetic acid-induced gastric mucosal lesions in the rat. However, the mechanisms remain unclear. This study aimed to investigate whether GLPS had a direct mucosal healing effect in the indomethacin-treated rat, and to explore the possible mechanisms by determining the gastric mucosal mRNA and protein levels of TNF-alpha and ornithine decarboxylase (ODC) activity. These findings indicated that GLPS produced a mucosal healing effect in the rat model, perhaps due partly to the suppression of TNF-alpha.
Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions.
Am J Chin Med. 2002;30(2-3):245-54.
Acute p.o. administration of absolute ethanol (1.0 ml/kg) to fasted rats produced extensive necrosis of gastric mucosa. Pretreatment with p.o. administration of propolis ethanol extract could effectively and dose-dependently prevent such necrosis. This protective effect is called "cytoprotection. "The maximal cytoprotective effect against absolute ethanol (AE)-induced gastric mucosal lesion was observed 1 hour after propolis extract administration. A gross examination of the gastric mucosa showed a marked improvement in groups receiving PEE. In order to further investigate the gastric protective mechanism of propolis, lipid peroxidation (LPO) levels in vivo and in vitro were estimated. Propolis exhibited dose-dependent superoxide scavenging activity and antioxidant effects on AE-induced LPO in rat gastric mucosal homogenates. It was concluded that the gastric protective mechanism of propolis ethanol extract was due, at least in part, to its ability to inhibit LPO, and hence indirectly protect the gastric mucosa from oxidative stress.
A substance secreted by mucous cells in the lining of the stomach seems to act as a natural antibiotic, protecting against deep infection by Helicobacter pylori -- the bacterium that causes most cases of stomach ulcers. Researchers reporting in the journal Science say H. pylori usually only infects the surface layer of the stomach, rarely making it into the deeper layers of the stomach wall. Dr. Minoru Fukuda of the Burnham Institute in La Jolla, California, told Reuters Health that he and his colleagues observed a "very nice correlation" between decreasing amounts of H. pylori and increasing concentrations of a particular type of mucin, a substance produced by mucous glands, at deeper layers of the stomach lining. This substance caused H. pylori to lose its shape, became immobile, and eventually die in lab experiments. On the other hand, another type of mucin produced at the surface of the stomach actively supported the growth of the organism. His team believes the bug-killing mucin could help in the design of safer drugs that could treat stomach ulcers and prevent stomach cancer associated with H. pylori. Fukuda predicted that cows can be bred to produce inhibitory mucins in their milk, an inexpensive way to help eradicate H. pylori infection. Science, August 13, 2004.
Chinese Herbs for Ulcer
Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats.
Gen Pharmacol. 1997 Mar;28(3):469-73.
The action of Codonopsis pilosula extract in 5 animal models of gastric ulcer was investigated. It was found that codonopsis extract had higher efficacy on gastric ulcer induced by stress, acetic acid and sodium hydroxide and little significant effect on ulcers induced by pyloroligature and indomethacin. The codonopsis extract was also capable of reducing gastric acid pepsin secretion. It is possible that inhibition of gastrointestinal movement and propulsion is one of the mechanisms underlying the antiulcer action of codonopsis extract.
In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines
used to treat ulcer diseases.
J Ethnopharmacol. 2005 Apr 26;98(3):329-33.
Infection by Helicobacter pylori has been ascertained to be an important etiologic impetus leading usually to chronic active gastritis and gastric ulcer with growing incidences worldwide. Utilizing as the test pathogen a standard and five clinic strains of Helicobacter pylori, the antibacterial action was assessed in vitro with ethanol extracts of 30 Chinese herbal medicines which have been frequently prescribed since ancient times for treating gastritis-like disorders. Among the 30 tested materials, the ethanol extracts of Abrus cantoniensis (Fabaceae), Saussurea lappa (Asteraceae) and Eugenia caryophyllata (Myrtaceae) were strongly inhibitory to all test strains (MICs: approximately 40mug/ml), and Hippophae rhamnoides (Elaeagnaceae), Fritillaria thunbergii (Liliaceae), Magnolia officinalis and Schisandra chinensis (Magnoliaceae), Corydalis yanhusuo (Papaveraceae), Citrus reticulata (Rutaceae), Bupleurum chinense and Ligusticum chuanxiong (Apiaceae) substantially active with MICs close to 60.0mug/ml. As to antibacterial actions of the aqueous extracts of the same drugs, those derived from Cassia obtusifolia (Fabaceae), Fritillaria thunbergii and Eugenia caryophyllata were remarkably inhibitory against all the six Helicobacter pylori strains (MICs: approximately 60mug/ml). The work compared almost quantitatively the magnitude of the anti-Helicobacter pylori actions of the 30 most prescribed gastritis-treating Chinese herbal drugs, and located as well some source plants where potent anti-Helicobacter pylori phytochemicals could be characterized.
Gastroprotective effects of Amla Emblica officinalis on in vivo test models in rats.
Phytomedicine. 2002 Sep;9(6):515-22.
An ethanol extract of Amla was examined for its antisecretory and antiulcer activities employing different experimental models in rats, including pylorus ligation Shay rats, indomethacin, hypothermic restraint stress-induced gastric ulcer and necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl). Oral administration of Amla extract at doses 250 mg/kg and 500 mg/kg significantly inhibited the development of gastric lesions in all test models used. The results indicate that Amla extract possesses antisecretory, anti ulcer, and cytoprotective properties.
Additional anti ulcer herbs
Ulcer relief with Probiotics in
Up until recently, peptic ulcer disease was thought to be caused by an imbalance between acid and pepsin secretion, as well as defensive factors such as bicarbonate secretion and gastric mucosal barrier. The isolation of Helicobacter pylori from patients with chronic gastritis and duodenal and gastric ulcers has revolutionized thinking about the causes of ulcers. Current data suggest that persistent infection with Helicobacter pylori may account for peptic ulcer disease. In this study, 59 adult volunteers infected with H. pylori were given Lactobacillus- and Bifidobacterium-containing yogurt (AB-yogurt) twice daily after a meal for 6 weeks. Eleven subjects positive for H. pylori infection were treated with milk placebo as control subjects. H. pylori bacterial loads were determined with use of a breath test, which was performed before and 4 and 8 weeks after the start of AB-yogurt supplementation. Results: Yogurt containing probiotics suppressed H. pylori infection.
When you purchase yogurt, makes sure the label says that it contains these organisms. Or, you may directly supplement with probiotics.
People who smoke or use high amounts of table salt on their food appear to be at increased risk for gastroesophageal reflux, a disease in which stomach juices flow back into the esophagus, European researchers report. In contrast, tea and alcohol, which have been identified as culprits in past studies, did not increase the risk.
Ulcer natural treatment questions
Q. I have read and appreciated your informative book about Pregnenolone! Is there any known link between the sublingual tablets (5 mg. daily) and increased stomach acid or ulcers?
A. I have not seen such studies regarding the relationship of pregnenolone and ulcer formation. It is known that cortisol use can increase ulcer formation, but I don't know if pregnenolone has any influence. In my opinion, it is best not to use pregnenolone often. See pregnenolone for cautions regarding the use of this hormone.
Is it true that the best herb for hyper acidity is filipendula ulmaria? What do u think is the best herb for hyperacidity?
I have not studied the benefits of filipendula ulmaria, known as the meadowsweet herb. You may consider some of the herbs or supplements listed above for ulcer prevention or treatment.
What is the treatment / nutrient for a stress related acid
The question is too broad and non-specific to answer accurately.
I'm a journalist working on an article about Vitamin U, methylmethionine sulfonium chloride as a treatment for ulcers. I'm looking for a doctor to comment.