Uridine by Ray Sahelian, M.D. (natural medicine information)
Cytidine and uridine can stimulate brain phosphatide synthesis. MIT brain researchers are working on a combination of dietary supplements that may be helpful in mind enhancement or the treatment of age related mental decline. The MIT research suggests that a cocktail treatment of omega-3 fatty acids, uridine and Choline are all needed by brain neurons to make phospholipids, the primary component of cell membranes. After adding those supplements to the diets of gerbils, the researchers observed a dramatic increase in the amount of membranes that form brain cell synapses, where messages between cells are relayed. Damage in brain synapses is believed to cause the dementia that characterizes Alzheimer's disease. For an excellent supplement comprised of several herbs and nutrients, consider Mind-Power-Rx.
Definition of Uridine - Uridine is a molecule known as a nucleoside formed when uracil is attached to a ribose ring. If uracil is attached to a deoxyribose ring, it is known as a deoxyuridine.
High Quality products formulated by a
medical doctor


Consider highly popular all natural products formulated by a world famous
medical doctor, Ray Sahelian, M.D. These include
Mind Power Rx for better
mental focus, concentration, and mood; Diet Rx which helps you eat less; Good Night
Rx for better sleep; Eyesight
Rx for better vision; MultiVit
Rx a daily comprehensive multivitamin for more energy and
vitality; Joint Power Rx
for healthy joints; Prostate Power Rx
for a healthy prostate gland; Passion Rx
for sexual enhancement in men and women; and
Veg Rx which supplies the missing nutrients in a vegetarian
diet.
Uridine Research Update
Cytidine and Uridine Increase Striatal CDP-Choline Levels Without Decreasing
Acetylcholine Synthesis or Release.
Cell Mol Neurobiol. 2006 Apr 25;Ulus IH, Watkins CJ, Cansev M, Wurtman RJ.
Department of Pharmacology and Clinical Pharmacology, Uludag University Medical
School, Bursa, Turkey.
Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels and release. These data show that cytidine and uridine can stimulate brain phosphatide synthesis without diminishing acetylcholine synthesis or release.
Synaptic
proteins and phospholipids are increased in gerbil brain by administering
uridine plus docosahexaenoic acid orally.
Brain Res. 2006 Apr 19; Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L,
Marzloff G.
Department of Brain and Cognitive Sciences, Massachusetts Institute of
Technology, MIT, Cambridge, MA
The synthesis of brain phosphatidylcholine may utilize three circulating
precursors: choline; a pyrimidine (e.g., uridine, converted via UTP to brain CTP);
and a PUFA (e.g., docosahexaenoic acid); phosphatidylethanolamine may utilize
two of these, a pyrimidine and a PUFA. We observe that consuming these
precursors can substantially increase membrane phosphatide and synaptic protein
levels in gerbil brains. Alzheimer's disease brains contain fewer and smaller
synapses and reduced levels of synaptic proteins, membrane phosphatides, choline
and DHA. The three phosphatide precursors might thus be useful in treating this
disease.
Effects of
uridine in models of epileptogenesis and seizures.
Epilepsy Res. 2006 Apr 16; Zhao Q, Marolewski A, Rusche JR, Holmes GL.
Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical
School, Lebanon, New Hampshire
Uridine, a possible endogenous antiepileptic modulator, has been demonstrated to
have anticonvulsant effects in some models of epilepsy. In this study, we
examined possible neuroprotective effects of uridine by administering the agent
following lithium-pilocarpine induced status epilepticus. There was a
trend for reduced EEG spike frequency, improved visual spatial memory and better
histology score in rats receiving uridine. The antiepileptogenic and
anticonvulsant effects of uridine were studied by administering uridine to rats
undergoing rapid kindling or following full kindling. In the rapid kindling
models, uridine had a moderate antiepileptogenic and anticonvulsant effect.
These results suggest uridine may have potential to aid in the prevention and
treatment of epilepsy.
Uridine emails
Q. I am looking for a daily rridine treatment for a patient (20 mo old female
with hereditary Orotic aciduria) , and having difficulties finding a supplier.
Your web site comes up as a source for information. I would appreciate if you
can let me know of a pharmaceutical grade supplier for Uridine.
A. Sorry, we have not looked into sales of uridine or suppliers.
Q. I'm just
wondering uridine is not found in Mind Power Rx formula.
A. There are dozens of effective mind boosting herbs and nutrients.
Mind Power Rx has about a dozen of them. Not every potential mind enhancer can
be included in a formula.