Xanthohumol health benefit by Ray Sahelian, M.D. Cancer protection and other health benefits

Xanthohumol is the main flavonoid found in hops, an herb used to make beer. Xanthohumol is lost in significant quantities in the conventional brewing process. Commercial beers contain less than 0.2 mg xanthohumol per liter. Xanthohumol is an antioxidant.

Nature's Way Hops Flowers, 310 mg
Hops Supplement Facts:
Hops (flower)
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Recommendations: Take 1 or 2 hops capsules in the evening. The hops capsules may be opened and placed in a cup with hot water for tea, and lightly sweetened with stevia.
* Hops daily value not established

Xanthohumol and cancer protection
Xanthohumol may have anti cancer potential, including anti leukemia and liver cancer potential. There are several ways that xanthohumol may be an anti cancer agent. Xanthohumol may cause apoptosis of cancer cells, and it may also prevent angiogenesis or blood vessel growth. Xanthohumol may also work by down-regulation of NFkappaB activation in BPH-1 (benign prostate hyperplasia) cells and in vitro studies show this compound to prevent prostate cancer cell proliferation.

Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines.
Phytother Res. 2008 Nov; Department of Bioengineering, Tatung University, Taipei, Taiwan.
Xanthohumol is one of the main flavonoids in hop extracts and in beer. Very few investigations of xanthohumol have studied hepatocellular carcinoma. In this study, the inhibitory effects of xanthohumol on human hepatocellular carcinoma cell lines were investigated. The IC(50) values of xanthohumol for two hepatocellular carcinoma cell lines and one normal hepatocyte cell line were 108, 166 and 211 microm, respectively. Normal murine hepatocyte cell line had more resistance to xanthohumol than hepatocellular carcinoma cell lines. Besides, the inhibitory effects of xanthohumol on human hepatocellular carcinoma cell lines were attributed to apoptosis. Hop xanthohumol was more efficient in the growth inhibition of hepatocellular carcinoma cell lines than the flavonoids silibinin and naringin from thistle and citrus. Xanthohumol from hops effectively inhibits proliferation of human hepatocellular carcinoma cells in vitro.

Xanthohumol and estrogen
Lager beer, alcohol-free beer, stout beer, and xanthohumol rich stout beer (200 microL/mL) decrease aromatase activity. This may lead to a decrease in estrogen synthesis although different individuals may metabolize xanthohumol in a different way.

Hops and beer
Hops, an essential beer ingredient, are a source of prenylflavonoids, including 8-prenylnaringenin, one of the most potent phytoestrogens. 8-prenylnaringenin concentrations in beers are generally low. However, human intestinal microbiota may activate up to 4 mg/L isoxanthohumol in beer into 8-prenylnaringenin. Depending on interindividual differences in the intestinal transformation potential, this conversion could easily increase the 8-prenylnaringenin exposure 10-fold upon beer consumption.

Xanthohumol and brain receptors
Xanthohumol may bind to GABA receptors and induce relaxation.

Xanthohumol suppliers - this is a press release
BioNovix Launches Dietary Supplement Containing Anti-Oxidant Xanthohumol
SCOTTSDALE, Ariz., Jan 02, 2007- BioNovix, Inc., a consumer health products company, is launching the first bioactive dietary supplement formulated with xanthohumol, a powerful anti-oxidant. The xanthohumol compound is derived from hops, and has been identified as an extremely potent anti-oxidant. BioNovix is the first company to develop a patented formula and process for enhancing and increasing the potency of xanthohumol so that it can be used in a soluble form, facilitating assimilation in the body. BioNovix has termed their formulation of xanthohumol, which will be marketed under the name MeridiumXN.

Xanthohumol emails
We have a water soluble form of xanthohumol that we call MeridiumXN. In addition to the MeridiumXN supplement, we are offering an in home test strip to measure isoprostane levels in a user's urine as a measure of the amount of oxidative stress in their system.
    Thanks for letting us know about your xanthohumol product MeridiumXN. We wish you success with your endeavor.