Zallouh root herb for sexual enhancement and natural aphrodisiac plant
Lebanese Viagra?
How well does it work and is it safe to use daily?
January 1 2017 by Ray Sahelian, M.D.

Zallouh is the dried root of the herb Ferula Hermonis which grows at a height of about 2000 meters above sea level on the side of Mount Hermoun between Lebanon and Syria. It has been used historically in the region as an aphrodisiac, but it has only been in the past few years that scientists have evaluated it's chemical properties. Zallouh contains a number of compounds, including sesquiterpenes. Years ago articles appeared in several magazines that called it the " Lebanese Viagra."

Research in rodents
An intriguing study in male rats showed that zallouh, when given one time, enhanced sexual activity, and also raised blood levels of testosterone. However, when zallouh was given daily for 10 days, it actually reduced sexual activity, and also reduced testosterone levels. This is difficult to explain but my guess would be that perhaps the dose of zallouh given to the rats was too high.

Human research
As of 2016, I am not aware of studies with this herb done in humans and that have been published in peer reviewed journals. If you would like to try a potent herbal formula that enhances sexual pleasure and performance, see below.

Passion Rx for men and women
This sexual formula provides results that are often noticed with 2 to 3 days and continue to improve over several days of use. Renowned physician and herbal expert Dr. Ray Sahelian, M.D, author of Natural Sex Boosters, has discovered a exotic aphrodisiac herbal extracts from the Amazon jungle, India, China, Malaysia, and Africa, that, when combined, improve sexual desire and performance, as well as to simply enhance sexual pleasure. The potent nutrients and herbal extracts in Passion Rx include acetylcarnitine, ashwagandha, catuaba, choline, cnidium monnieri, coleus forskohlii, dmae, epimedium, maca herb, mucuna pruriens, muira puama, passion flower, pfaffia paniculata, rehmannia, rhodiola, shilajit substance, tribulus terrestris, tongkat ali. Passion Rx does not have zallouh extract at this time. Another version is available with yohimbe, an herb from Africa.

Zallouh safety and side effects, risk, danger
The crude oil from zallouh can enhance erectile function in rodents, however it appears to be toxic if used for a long period of time in high doses. In mice, the ingestion of 3 mg/kg of aqueous extract of zallouh for six weeks inhibited social aggression. Body weight and other sexual accessory organ weights were significantly reduced. The ingestion of high doses of zallouh by male mice resulted in a reduction of their fertility.
   Sometimes herbs have different effects when given for brief periods as opposed to prolonged periods. Also, the dose of an herb makes a significant difference on how effective it is. Too much can be counterproductive and cause side effects.

Review and analysis
At this point it is difficult to make any firm recommendations regarding the use of zallouh to enhance libido or to treat erectile dysfunction. Occasional use appears to be safe, but long term use is discouraged until more is known as to the safety of chronic zallouh ingestion. It is quite possible that the dosages used in rodent studies were quite high compared to what humans would ingest for sexual enhancement purposes.
   In the meantime, if you are interested in a doctor formulated herbal sexual product, consider Passion Rx, which is quite popular. The version with yohimbe works quicker.

Compounds found in zallouh herb, plant
The extract has sesquiterpenes called ferutinin, teferin and teferdin.

Tests in rodents, mice and rats
Some of the studies with zallouh herb or extract in rodents have not shown encouraging results. This could be due the dosage used (too little or too much), or the different response rodents would have to this herb than humans.

BMC Complement Altern Med. 2015. Acute and subchronic in-vivo effects of Ferula hermonis and Sambucus nigra and their potential active isolates in a diabetic mouse model of neuropathic pain. Without the use-limiting-side-effects of existing therapies, Ferula, Elder and their active isolates have shown significant results in ameliorating dibetes mellitus and long standing diabetes-induced complications.

Exp Biol Med. 2011. Effect of Ferula hermonis root extract on rat skeletal muscle adaptation to exercise. Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Jordan. This study investigated the effects of F. hermonis extract alone or combined with exercise on rat skeletal muscle fibers. Adult male rats were divided into four groups: control-sedentary (CS) that had no treatment or exercise; ferula-sedentary (FS) that was orally treated with ferula extract at a dose of 60 mg/kg/rat every other day over a period of 20 d; control-exercised (CE) that was trained by swimming for 40 min every other day; and ferula-exercised (FE) that received ferula and performed exercise. At the end of experiments, the fiber diameter and number of muscle nuclei of tibialis anterior were measured by using immunofluorescent techniques and software analyses. The FE group showed significant increases in muscle weight, fiber size and nuclear number compared with the other groups. However, no significant changes in the aforementioned parameters were found among the CS, FS and CE groups. Ferula treatment and exercise were additive to each other. In conclusion, short-term exercise combined with administration of F. hermonis extract was more effective in enhancing the growth of skeletal muscle fibers than exercise alone.

Role of ferutinin in the impairment of female sexual function induced by Ferula hermonis.
Physiol Behav. 2006. Department of Biomedical Sciences, Section of Pharmacology, and National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and Reggio Emilia, Via Campi Modena, Italy.
In the present study, we evaluated the effects of single components of Ferula hermonis extract on female rat sexual behavior. Ovariectomized rats hormonally primed with estradiol benzoate and progesterone were acutely treated by oral gavage with ferutinin, teferin and teferdin. Thereafter they were tested for: a) partner preference, b) receptivity, c) proceptivity, d) paced mating behavior. In the partner preference test, the choice of the female for a sexually active male was not influenced by the different treatments. Similarly, during the paced mating test, the contact-return latencies as well as the percentage of exits from the male compartment were not different in control and treated rats. Therefore none of the three compounds showed the capacity to alter sexual motivation. On the other hand, ferutinin, but not teferin and teferdin, significantly inhibited female receptivity. These results suggest a primary role of ferutinin in the impairment of sexual behavior elicited by Ferula hermonis extract in hormone primed-female rats.

Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats.
Int J Impot Res. 2003.
Sexually potent and sluggish/impotent male rats were orally treated with an extract of zallouh (Ferula hermonis) (30 and 60 mg/kg). The acute zallouh administration stimulated sexual motivation in potent rats and improved copulatory performance in sluggish/impotent rats. This last effect was elicited only by the higher zallouh dose, which, in parallel, increased serum testosterone levels in rats. On the contrary, when the extract was subchronically administered (10 days) a marked reduction in the percentage of rats achieving ejaculation was detected, together with a general impairment of the copulatory pattern. Furthermore, the repeated administration of the zallouh extract resulted in a significant reduction of testosterone levels in comparison with controls. The present results discourage a repeated assumption of zallouh, while suggesting its acute administration to improve the performance in sexual dysfunctions.
     Comments: it appears that zallouh is more suited for short term use and not necessarily appropriate for long term sexual health. One option is to use a zallouh supplement for a few days and then take a couple of week or more off.

A comparative study of Ferula hermonis root extracts and sildenafil on copulatory behavior of male rats.
Fitoterapia. 2003.
The effect of 600 mg/kg given by oral route to rats of Ferula hermonis roots extracts was evaluated on sexual behavior of male rats. Petroleum ether and ethyl acetate extracts of zallouh produced a significant decrease in both the mount rate (MR) and the intromission rate (IR), significant prolongation of intromission latency (IL) was observed when these extracts were compared with both controls and sildenafil. Methanolic zallouh extract produced a significant increase in MR while no effect has been observed on IR or IL in comparison with control. The effect of zallouh water extract was not significantly different from controls for the MR and IR, but there was a significant prolongation in the IL.

Questions
Do you know where I can buy zalouh pills to enhance sex drive ?
   If you do a search on the internet, you can find some websites that sell the capsules. By the way, the correct spelling is zallouh, not zalouh.

Daru. 2013. Cytotoxic activities of phytochemicals from Ferula species. Ferula species are reputed in folk medicine for the treatment of a variety of disorders. The present study investigated the cytotoxic activity of 11 phytochemicals (conferone, farnesiferol A, acantrifoside E, mogoltadone, diversin, galbanic acid, herniarin, 7-isopentenyloxycoumarin, umbelliprenin, stylosin and tschimgine) from Ferula species together with a newly synthesized prenylated derivative of curcumin (gercumin II). Cytotoxic activity of phytochemicals was evaluated against ovarian carcinoma (CH1), lung cancer (A549) and melanoma (SK-MEL-28) cell lines using MTT assay. Overall, moderate cytotoxic activity was observed from the tested compounds with IC50 values in the micromolar range. The highest activity against CH1 and A549 lines was from conferone while stylosin and tschimgine were the most potent compounds against SK-MEL-28 line. In conclusion, the findings of the present investigation did not support a potent cytotoxic activity of the tested phytochemicals against CH1, A549 and SK-MEL-28 cell lines. With respect to previous reports, the beneficial impact of these phytochemicals in cancer therapy may be more attributable to their chemopreventive or chemosensitizing activity rather than direct cytotoxic effects.

Additional information of interest
List of herbs for health and medical conditions. A list of sexual enhancement herbs, lj100 is a potent tongkat ali extract. Clavo_huasca is an herb from the Amazon rainforest used as an aphrodisiac. Graviola is touted an anti tumor herb. Penis enlargement pills, do they work, are they effective? Xanthoparmelia lichen is sometimes found in sexual products. Mangosteen has xanthone compounds. Ahcc immune product sale serrapeptase proteolytic enzyme, saw palmetto herb. Better orgasm with Passion Rx which is a product that can be a solution in some people who have impotence. Many herbal sexual products are available on the market including VigRx pill and Zenerx capsule. Coq10 supplement for mitochondrial energy. 5-HTP can be used by people who have too much libido, 5-HTP can dampen sexual desire.

J Sex Med. 2010. Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women? Female sexual dysfunction (FSD) is a complex and multifactorial condition. An increased incidence of FSD is especially associated with the decline of estrogen. Thus, menopause is a critical phase for FSD complaints. In this context, medicinal plants may be a therapeutic option.AIM:To identify and describe the popular and clinical uses of medicinal plants for FSD treatment in climacteric women. We highlighted the majority of the plants commonly involved with the female reproductive system including: Angelica sinensis, Cimicifuga racemosa, Ferula hermonis, Ginkgo biloba, Humulus lupulus, Lepidium meyenii, Tribulus terrestris, Trifolium pratense, and Vitex agnus-castus.