Zyflamend is a combination of herbal extracts. Unlike many herbal products on the market, the makers of Zyflamend have actually gone through the trouble of conducting tests on this product. It is not easy to do such studies because they take a lot of time and planning, and they cost a lot.
  
Zyflamend studies
In vitro studies shows Zyflamend suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called apoptosis. Zyflamend has the ability, in culture at least, to reduce prostate cancer cell growth. But, will the same benefit occur in humans when Zyflamend is taken as a supplement? I don't know. Zyflamend also has some anti-inflammatory potential.
   Until actual human studies are done, we won't know what kind of an effect a Zyflamend supplement will have on human health and disease. A trial is underway to determine the role of Zyflamend in prostate cancer prevention by researchers at the Department of Urology, Columbia University, New York, New York.

Zyflamend 120, New Chapter

This product contains the following herbs: Basil, Turmeric, Ginger, Green tea, Rosemary, Hu Zhang, Barberry, Oregano, and Scullcap.
See below for a discussion of the herbs found in this Zyflamend product.



 

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Subscribe to a FREE Supplement Research Update newsletter. Twice a month you will receive an email with a review of several studies on various supplements and natural medicine topics, including Zyflamend for inflammation, and their practical interpretation by Ray Sahelian, M.D.

Zyflamend 120 has the following phytonutrient ingredients:
Basil (Ocimum sanctum) contains ursolic acid, which may enhances detoxification and support the inflammation response.

Turmeric is a unique curcumin phytonutrient complex that may have additional benefit when combined with green tea polyphenols.

Ginger extract offers numerous beneficial constituents.

Green tea has potent polyphenols and has been praised highly by scientists and the media.

Rosemary herb is starting to become more popular.

Hu Zhang: (Polygonum cuspidatum) is an herb that has one of the richest known content of resveratrol, a compound that has been found in rodents to have potential anti-aging properties.

Chinese Goldthread or Barberry has a unique berberine phytonutrient complex, naturally supports the inflammation response system.*

Oregano is a source of large number of compounds that promote a healthy inflammatory response.

Scutellaria: scullcap: Unique baicalin phytonutrient complex, naturally supports healthy inflammatory responses.

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Animal study, benefit for oral cancer
The herbs in Zyflamend have anti oral cancer potential. A rodent study done in 2008 shows possible benefits of this supplement against oral cancer.

Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model.
Carcinogenesis. 2008 Nov; Yang P, Sun Z, Chan D, Cartwright CA, Vijjeswarapu M, Ding J, Chen X, Newman RA. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Aberrant arachidonic acid metabolism, especially altered cyclooxygenase and 5-lipoxygenase (LOX) activities, has been associated with chronic inflammation as well as carcinogenesis in human oral cavity tissues. Here, we examined the effect of Zyflamend, a product containing 10 concentrated herbal extracts, on development of 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced inflammation and oral squamous cell carcinoma. A hamster cheek pouch model was used in which 0.5% DMBA was applied topically onto the left cheek pouch of male Syrian golden hamsters either three times per week for 3 weeks (short term) or 6 weeks (long term). Zyflamend was then applied topically at one of three different doses onto the left cheek pouch three times for 1 week (short-term study) or chronically for 18 weeks. Zyflamend significantly reduced infiltration of inflammatory cells, incidence of hyperplasia and dysplastic lesions in a concentration-dependent manner. Our study demonstrates that Zyflamend inhibited LTB(4) formation and modulated adverse histopathological changes in the DMBA-induced hamster cheek pouch model. The study suggests that Zyflamend might prevent oral carcinogenesis at the post-initiation stage.

In vitro study
In the laboratory, Zyflamend decreases COX-1 and COX-2 enzyme activity. Nutrition and Cancer, October 2005.
Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutr Cancer. 2007;57(1):78-87.

Zyflamend side effects
As of now, no significant Zyflamend side effects have been reported in the medical literature. It is possible that rare individuals may have an allergy to one or more of the components of this product. It is always a good idea, when taking a new product, to start with the lowest dose. Consult with your health care provider if you are considering the use of Zyflamend or other supplements.

Q. I had to stop taking Zyflamend because I determined that it causes diarrhea. Any ideas? It's not the turmeric, as I switched to your turmeric product without problems. My chiropractor and nutritional advisor and I have puzzled over this. Inflammation is a problem for me, and we hoped that Zyflamend would help. It took about two weeks for us to determine that among the supplements I was taking (for h. pylori infection), something in the Zyflamend was causing me to have loose stools within a few hours of taking it. After an 8 month hiatus I decided to try it again, taking one softgel, with food. I was on the toilet within an hour.
   A. This is the first report we have heard about Zyflamend side effects.

I was reviewing the information about Zyflamend on your website and wanted to write regarding the side effects I experienced. After about a month of taking it as directed, two times daily with food, I developed a severe case of diarrhea. For some time leading up to the most severe -- food in, food out w/i an hour -- I had increasingly soft stools and gurgling intestines. I didn't feel sick or anything else unusual, so I just thought it was a virus. Eventually, I went to the emergency room and none of the blood tests, urinalysis or fecal analysis indicated an infection of any sort. The ER doctor suggested I stop taking all supplements, which I did, and the diarrhea ceased in within a few days. It has been two months since then, and I decided to go ahead and try taking the Zyflamend again to see if it was the cause of the diarrhea. Unfortunately, after just a couple of days, I started experiencing loose stools and intestinal gurgling again, which will most likely lead to the diarrhea if I continue. I don't know which of the ingredients in the product cause the problem for me, but I am disappointed that I cannot take such a promising product for the inflammation in my joints.
   A. Interesting. This is the second report of Zyflamend side effects of diarrhea. November 2008.

I just read your page on Zyflamend and noticed two people got loose bowels from it. I have been taking it for about a month and have gotten loose bowels too. I am so disappointed because it was really helping my pain. I take it for thoracic outlet syndrome in both my arms. I could hardly get my coat on because of the pain. Some one said to take fish oil but that lowers blood pressure and I have very low blood pressure so I'm scared to take that.

i have had bouts of diarrhea with no known cause. i began to realize that it seemed to be associated with the zyflamend. i did several trials of not taking it and taking it. it became obvious that it was the zyflamend. i googled zyflamend side effects and came across your website. thought you might be interested. April 2009.

New Chapter Zyflamend research update
Zyflamend, a Polyherbal Preparation, Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis Through Down-Regulation of NF-kappa B Activation and NF-kappa B-Regulated Gene Products.
Nutr Cancer. 2007;57(1):78-87. Sandur SK, Ahn KS, Ichikawa H, Sethi G, Shishodia S, Newman RA, Aggarwal BB.
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.
Zyflamend, a polyherbal preparation, was designed based on constituents that exhibit antiproliferative, antiinflammatory, antioxidant, antiangiogenic, and apoptotic activities through a mechanism that is not well defined. Because the nuclear factor (NF)-kappaB has been shown to regulate proliferation, invasion, and metastasis of tumor cells, we postulated that Zyflamend modulates the activity of NF-kappa B. To test this hypothesis, we examined the effect of this preparation on NF-kappaB and NF-kappaB-regulated gene products. We found that Zyflamend inhibited receptor activator of NF-kappa B ligand-induced osteoclastogenesis, suppressed tumor necrosis factor (TNF)-induced invasion, and potentiated the cytotoxicity induced by TNF and chemotherapeutic agents, all of which are known to require NF-kappa B activation. Overall, our results indicate that Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.

Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression.
Nutr Cancer. 2005;52(2):202-12. Bemis DL, Capodice JL, Anastasiadis AG, Katz AE, Buttyan R. Department of Urology, Columbia University Medical Center, New York, NY 10032
Cyclooxygenase (COX) inhibitors have suppressive effects on several types of cancer cells including prostate cancer. In this study, we considered the potential COX-inhibitory activity of a unique anti-inflammatory herbal preparation Zyflamend; and analyzed its effects on the human prostate cancer cell line LNCaP. COX inhibitory activity of Zyflamend was determined by a spectrophotometric-based assay using purified ovine COX-1 and COX-2 enzymes. Zyflamend dramatically decreased COX-1 and COX-2 enzymatic activity. Elevated p21 expression coincided with attenuated cell growth following treatment of LNCaP cells with Zyflamend. PARP cleavage fragments were evident, and caspase-3 activity was upregulated over the control indicating the ability of Zyflamend to induce apoptosis of these cells. Androgen receptor expression levels declined by 40%, and decreases were observed in the active forms of Stat3 and PKC(alpha/beta) in Zyflamend-treated LNCaP cells. Zyflamend inhibited both COX-1 and COX-2 enzymatic activities, suppressed cell growth, and induced apoptosis in LNCaP cells. However, our data suggests that the effects are likely due to COX-independent mechanisms potentially involving enhanced expression of p21 and reduced expression of AR, pStat3, and pPKC(alpha/beta).

New Chapter Zyflamend 120 Questions:
Q. Can Zyflamend supplement be taken daily forever?
   A. It's difficult to know since long term human trials have not been done with Zyflamend. The herbs in Zyflamend appear to have health promoting potential, but to be cautious, we suggest taking breaks from use, although there are no accepted guidelines on how often and how long these breaks should be.

Q. Does Zyflamend have side effects?
   A. As of now, no Zyflamend side effects have been reported in the medical literature.

Q. Will taking Zyflamend reduce the risk for prostate cancer?
   A. The influence of Zyflamend on prostate cancer is not known in humans since in order to find out for sure, Zyflamend would need to be given for several years to a group of older men and compared to another group given placebo pills. Since no such Zyflamend prostate cancer study has been done, no one knows for sure.

Q. I read that Zyflamend is a Cox inhibitor. Is that true?
   A. One laboratory study has shown that the herbs in Zyflamend inhibited both COX-1 and COX-2 enzymatic activities, suppressed cell growth, and induced apoptosis in prostate cancer cells. Whether these same benefits would occur if humans ingested a Zyflamend supplement for prolonged periods is not known at this time.

Q. I read that Zyflamend is recommended for colitis as an natural antiinflamatory and restorative. Please comment.
     A. We have not seen any human studies with Zyflamend that can allow us to make an informed comment regarding colitis or natural antiinflammatory.

Q. Am considering taking either Serrapeptase or Zyflamend for inflammation reduction and prostate wellbeing. Do you have any comparative research analyzing these two herbal products? Serrapetase and Zyflamend both seem fairly similar in their performance.
   A. There is very little human research regarding either serrapeptase or Zyflamend, and we have not come across any evaluative studies comparing the two.

Q. I am currently breastfeeding and am wondering if any info is available on the safety of taking zyflamend 120 while nursing.
   A. Many of the herbs in Zyflamend are healthy herbs that are normally found in the kitchen, however we have not seen any specific research with the use of Zyflamend and breastfeeding. We have no reason to suspect any untoward reaction would occur but we can't be 100 percent sure.

Q. I understand Zyflamend for inflammation is being promoted, what inflammatory conditions would Zyflamend be useful for? I am a naturopathic doctor and would like to use New Chapter Zyflamend for certain patients who may benefit from this product.
   A. It is quite likely that Zyflamend may be of benefit in certain medical conditions due to a wonderful mix of natural herbs it contains, however such human research is not available for us to make any definitive statements at this time.

Q. Would Zyflamend be detrimental to someone with cirrhosis?
   A. We have not seen any studies with Zyflamend in regards to cirrhosis or liver enzymes.

Q. I am the medical director of an integrative healing center at a major university. I wanted to let you know about this study regarding Zyflamend. Here is the press release from 2005. "Data from the Columbia University Department of Urology demonstrates that Zyflamend, a unique herbal extract preparation, suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called “apoptosis.” The data, published in the October edition of Nutrition and Cancer, showed Zyflamend, a patented formulation from New Chapter, has the ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78 percent and to induce cancer cell death or apoptosis. The research confirms Zyflamend has COX-1 and COX-2 anti-inflammatory effects, although its anti-cancer effects against prostate cancer were independent of COX-2 inhibition, supporting the postulation that some prostate cancer cells are not affected by COX-2 inflammation. Based on this research, Zyflamend shows value in early therapy for prostate cancer patients. On the strength of this laboratory research, Columbia University’s Department of Urology has commenced a Phase 1 human clinical trial testing Zyflamend ability to prevent prostate cancer in patients with prostatic intraepithelial neoplasia (PIN)."

Q. While there are benefits to inhibiting cox enzymes, these same enzymes perform important functions in the body. In the kidneys they produce prostaglandins like pge 2 that maintain renal hemodynamcis. NSAIDS are toxic to kidneys because they interfere with these same prostaglandins. Is Zyflamend safe for the kidneys? It is interesting to note that people also suffer from ulcers
from NSAID use, but don't seem to with Zyflamend.
   A. Not enough human research has been done with Zyflamend to determine its long term benefits and side effects. There are many herbs in Zyflamend and each herb has many compounds which all work in different ways rather that strictly as COX-2 inhibiting enzymes. Therefore, the effects of the herbs in Zyflamend supplements are not the same as taking a medication that is purely a COX-2 inhibitor.

Q. My husband has costochondritis and his doctor recommended him to take glucosamine with chondroitin for 3 months then stop the treatment for a month and then start it for another 3 months until 1 year, he already took it for the first 3 months, the pain comes and goes several time per week. I read about Zyflamend in a magazine, do you think that it can work for my husband? I'm really stress about this thing because of the place of the pain, we been several times in the emergency room of the Hospital thinking that it my be his heart and after been with a cardiologist, a gastroenterologist, even a pediatrician! and after all the test and studies you can imagine, they all end in that conclusion.
   A. It is impossible for us to predict whether Zyflamend will help with your husband but we wish him well. We have not come across any human research with the use of Zyflamend for costochondritis (as of August 2008).

Q. How do I keep us with Zyflamend research?
   A. Consider subscribing to Supplement Research Update newsletter and new Zyflamend research will be discussed when studies are published.