Aripiprazole side effects and benefits
May 20 2016 by
Ray Sahelian, M.D.


Aripiprazole is an atypical antipsychotic agent that has been employed as a therapy for schizophrenia and schizoaffective disorders. Some neuroleptics have been used in therapy for patients with borderline personality disorder, which is associated with severe psychopathological symptoms. It is a pharmaceutical drug that appears to be an effective agent in the treatment of patients with borderline personality disorder but it does have side effects.


Abilify Aripiprazole side effects, adverse reactions
Aripiprazole has fewer side effects compared to other antipsychotic medications. Worrisome aripiprazole side effects include extrapyramidal symptoms and motoric activation similar to akathisia (muscle spasm or jerking of all extremities). Common adverse reactions include headache; nausea; constipation; anxiety; restlessness; weakness; nervousness; sleepiness or unusual drowsiness; insomnia; rash; vomiting; and weight gain. Additional aripiprazole side effects will likely be discovered as more patients use this drug for the treatment of schizophrenia and in the treatment of affective disorders.


Interactions with dietary supplements
Do you know any negative interactions there are taking it with St. John's Wort herb?
   I have not seen studies were individuals were given both, but I would be careful mixing them since they are both potent and have several effects on neurotransmitters.

Antipsychotic Medicine and Personality Disorder Treatment
The anti-psychotic drug Abilify (aripiprazole) appears to be effective for patients with borderline personality disorder, often leading to improvements in health-related quality of life and interpersonal problems. Personality disorder is a type of mental illness in which people have trouble functioning with others. It can be associated with depression and psychopathological symptoms. A few antipsychotic agents have been used in therapy for patients with borderline personality disorder. The most common side effects reported with aripiprazole were headache, insomnia, nausea, numbness, constipation and anxiety. American Journal of Psychiatry, 2006.


Role of aripiprazole in treating mood disorders.
Expert Rev Neurother. 2006. Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Atypical antipsychotics have been used to treat patients with schizophrenia for many years, but now there is increasing evidence of their utility in the treatment of mood disorders. In the past few years, several atypical agents have received regulatory approval for use in mania. Some atypical antipsychotics are helpful in the treatment of manic symptoms, either alone or in combination with traditional mood stabilizers, such as lithium and divalproex. Although emerging data indicate that atypical antipsychotics will be a promising addition to those therapies that are currently available for managing patients during the maintenance phase of bipolar illness, their potential in the long-term management of bipolar disorder, and potential long term side effects, remains to be fully explored. Aripiprazole is an antipsychotic medication that differs from other atypical antipsychotic agents by its mode of action as a dopamine D2 partial agonist. It is administered orally and has a long half-life. Randomized studies have demonstrated the efficacy of aripiprazole compared with placebo in the treatment of acute relapse of schizophrenia and schizoaffective disorder, maintenance treatment of schizophrenia, treatment of acute mania, and prevention of manic relapse in patients who responded to the drug during a manic episode. Further studies are ongoing in bipolar and unipolar depression.
   Comments: For natural options to bipolar disorder treatment.


Treatment for delirium
Palliat Support Care. 2014. Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects. Haloperidol, risperidone, aripiprazole, and olanzapine were equally effective in the management of delirium; however, they differed in terms of their side-effect profile. Extrapyramidal symptoms were most frequently recorded with haloperidol, and sedation occurred most frequently with olanzapine.