Bromelain is an enzyme found in all parts of the pineapple plant but the highest concentration is found in the stem. Bromelain is a combination of several protein-digesting enzymes along with peroxidase, acid phosphatase, protease inhibitors, and calcium. Bromelain is most often used to help digestion and help reduce inflammation. It may also have anti-viral and immune influencing properties.
Bromelain side effects, safety,
toxicity, extended use, allergy
Bromelain supplements do not seem to have any obvious side effects. The use of a
bromelain supplement at 800 mg a day was used on a group of patients for a
period of 12 weeks without any significant side effects reported.
I was wondering what if any information / opinions you
have on the safety / effectiveness of bromelain mainly for digestive purposes. I
have read it is supposedly helpful also for the heart, but that it should be
taken along with vitamin E.
Thus far it appears to a be a safe natural product.
Long term use
I am taking a bromelain supplement for chronic inflammation, and would like to
to take it long term, but am unfamiliar with it's profile. I've seen some
websites say you should take it no longer than 10 days.
The use of a bromelain supplement at 800 mg was used on a group
of patients for a period of 12 weeks without any significant side effects. As
with any supplement, we suggest taking breaks from use unless the supplement is
necessary in the treatment of a condition and your doctor does not advise taking
breaks.
Allergy
I have been on bromelain 3000 mg a day and
quercetin 1500 mg a day. I have started itching after a month. Is this an
allergy to bromelain or quercetin?
It is not possible for us to tell whether your itching is an
allergy to these nutraceuticals, or some other ingredient in the capsule or
something else that it causing the problem in your diet or environmental
exposure. If the itching goes away and returns after using the supplement, then
it is more likely that the bromelain, quercetin or some ingredient in the
formula is causing the allergy.
Benefit
Bromelain, derived from the pineapple plant, is one of a group of
proteolytic enzymes (enzymes capable of digesting protein). It is widely
believed that most orally ingested enzymes are destroyed by the digestive juices
prior to being absorbed. However, there is evidence that some amounts can be absorbed intact. Proteolytic enzymes other than bromelain are
often used with people who suffer from malabsorption. It may contribute
to the digestion of protein, and may therefore be used as a digestive aid.
The medicinal qualities of pineapple are attributed to bromelain, a 95%-mixture of proteases.
These medicinal qualities include
anti-inflammatory, anti-thrombotic, fibrinolytic and anti-cancer functions.
Anti inflammatory
I read about bromelain that it has healing and antiinflammatory properties.
Can I give it for better wound healing after orthopedic surgery ?
We are not familiar with its use after surgery.
It does appear to have anti-inflammatory and antiviral activity.
Anti cancer agent?
Bromelain acts systemically, affecting multiple cellular and molecular targets.
The anti-cancer activity of bromelain consists
in the direct impact on cancer cells and their micro-environment, as well as in
the modulation of immune, inflammatory and haemostatic systems.
Blood thinning
Are bromelain and quercetin blood thinners?
They may have a slight blood thinning effect but I have not
seen conclusive studies yet. If they do thin the blood, it is likely to be
minimal. I can't be fully certain, this is my best guess.
Bursitis
So, after all the research on bromelain supplements,
would you say it's worth a try for bursitis of the hips, assuming there are no
extenuating circumstances?
There's very little research regarding the use of bromelain
supplements in joint disorders, therefore no statements can be made with
confidence.
Dental surgery
J Oral Maxillofac Surg. 2014. Perioperative bromelain reduces pain and swelling
and improves quality of life measures after mandibular third molar surgery: a
randomized, double-blind, placebo-controlled clinical trial.Majid OW1, Al-Mashhadani
BA2.Author information. The purpose of the present study was to compare the
effect of oral bromelain (4 × 250 mg) versus oral diclofenac sodium (4 × 25 mg)
on pain, swelling, trismus, and quality of life after surgical removal of
impacted lower third molars.
Muscle pain and ache
Preliminary comparison of bromelain and Ibuprofen for delayed onset
muscle soreness management.
Clin J Sport Med. 2002.
The purpose of this study was to determine whether a common bromelain regimen or
common ibuprofen regimen are effective in resolving pain and muscle dysfunction
associated with delayed onset muscle soreness of the elbow flexors. Forty
subjects who had not participated in an upper body resistance-training program 3
months prior to the study, suffered pain or injury in the nondominant arm, or
experienced an adverse response to nonsteroidal anti-inflammatory drugs or
pineapple (bromelain source) were recruited. Subjects were assigned to one of
four treatment groups (bromelain 300 mg three times a day, ibuprofen 400 mg t.i.d., placebo
t.i.d., and control) and began treatment immediately following the exercise
protocol. No differences among treatments were observed for any of the dependent
variables at any time. ROM deficits and pain peaked between 48 and 72 hours.
Peak torque deficiencies were observed between 24 and 72 hours. Ingestion of
bromelain and ibuprofen had no effect on elbow flexor pain, loss of ROM, or loss
of concentric peak torque as a result of an eccentric exercise regimen.
Osteoarthritis
and arthritis
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of
the knee: a randomized placebo-controlled pilot study.
QJM. 2006. Department of Primary Care, University of
Southampton, Southampton, Southampton, UK.
Previous studies suggest that bromelain, a pineapple extract, may be a safer
alternative or adjunctive treatment for knee osteoarthrits than current
conventional treatment. Subjects with a confirmed diagnosis of moderate
to severe knee osteoarthritis were randomized to 12 weeks of bromelain 800
mg a day or placebo, with a 4-week follow-up. Knee (pain, stiffness and function)
and quality-of-life symptoms were reported monthly in the WOMAC and SF36
questionnaires, respectively. No statistically significant differences were
observed between groups for the primary outcome. Both treatment groups showed
clinically relevant improvement in the WOMAC disability subscale only. Adverse
events were generally mild in nature. This study suggests that bromelain is not
efficacious as an adjunctive treatment of moderate to severe osteoarthritis.
Skin disease
Role of bromelain in the treatment of patients with pityriasis lichenoides
chronica.
J Dermatolog Treat. 2007. Department of Clinical Medicine and
Immunological Sciences - Section of Dermatology, University of Siena, Italy.
Pityriasis lichenoides is a rash of unknown cause. The rash can range from a
relatively mild chronic form to a more severe acute eruption. This skin
condition affects adolescents and young adults, usually before the age of 30.
Eight patients (3 males and 5 females) with
pityriasis lichenoides chronica were treated
for three months with oral bromelain (40 mg 3 times a day for 1 month, 40 mg
twice a day for 1 month and 40 mg/day for 1 month). All patients showed complete
clinical recovery after treatment. After one year of follow up, two patients
experienced relapse 6 months after suspension of therapy but responded to
another brief cycle of therapy. No side effects were encountered during therapy.
Sinusitis
Therapeutic use, efficiency and safety of the
proteolytic pineapple enzyme Bromelain -POS in children with acute sinusitis in
Germany. In Vivo. 2005.
The therapeutic efficiency and safety of the proteolytic enzyme bromelaine
obtained from pineapple (Bromelain -POS, Ursapharm GmbH, Saarbrucken, Germany)
was evaluated in children under the age of 11 years diagnosed with acute
sinusitis. Data from 116 patients in Germany were analysed in a study. Patient cohorts were either
treated with Bromelain -POS, in combination with Bromelain -POS and
standard therapies, or with standard therapies. The primary
parameter measuring effectiveness of the different treatment groups was the
duration of symptoms. The shortest mean period of symptoms was observed in
patients treated with Bromelain -POS alone (6.6 days), followed by the standard
therapy (7.95 days) and those treated with a combination of Bromelain-POS and
the standard therapy (9 days). Patients of the Bromelain -POS monotherapy
group showed a statistically significant faster recovery from symptoms compared to the other treatment groups. One 10-year-old male patient,
with a known pineapple allergy, showed a self-limiting mild allergic reaction.
No other unwanted side-effects were reported. This trial documents that the proteolytic pineapple enzyme Bromelain -POS is widely used in the treatment of
young children diagnosed with acute sinusitis in Germany and that the use of
proteolytic enzymes can benefit such patients.
Testimonial
I take bromelain and quercetin for my sinus
condition, and they have helped the condition for years.
Measuring the potency
What is the difference between Bromelain 45 Mg (225 I.U) and
5,000 M.C.U (Milk Clot Units Per Mg)?
MCU stands for milk clotting units and refers to the
proteolytic enzyme potency. Vitamins and minerals are measured in a variety of
ways including milligrams (mg), micrograms (mcg), or International Units (IU). A
measure of the potency of bromelain, which is an enzyme, is how quickly it can
dissolve a protein, in this case milk protein, is expressed as milk clotting
units (mcu). Bromelain is also measured as GDU, gelatin dissolving units. This
is a good question, I am not sure how these different measures compare.
Interactions with dietary
supplements
I am considering purchasing serrapeptase enzyme and
combining it with bromelain. Are you aware of any adverse effects of combining
the two?
We are not aware of any contraindications combining serrapeptase enzyme and
bromelain supplements, but we have not seen any studies combining the two and it
is possible that one person may find it compatible why another person could get
untoward side effects.
Questions
I came across bromelain in an email claiming it to
be a wonder drug. So I did some looking into it and it does sound pretty
amazing. It comes from pineapples, is drinking the juice or eating ready made
pineapple chunks do just as well as taking the supplement.
Taking a bromelain supplement is different than eating pineapple or
drinking pineapple juice since the fruit has many other compounds. There are countless beneficial substances in the foods and herbs we
consume, and bromelain is one of these, not necessarily a wonder drug.
Testimonial, lung health
I have taken a supplement of quercetin and bromelain
for about two years for lung health. It has been very good for me. The daily
dose of bromelain is a half of a gram, with seemingly no ill effect. A few weeks
ago I fell and hurt myself. I had supplemental bromelain and was probably taking
no more than two grams for a few days, and again I saw no problems like stomach
upset or the like. I later cut myself and the bleeding was minimal.
Source Naturals buy Bromelain
2000 GDU each pill
Buy Bromelain supplement
Supplement Facts buy bromelain capsules or tablets | ||
Serving Size: 1 Capsule | ||
Amount per Serving | % Daily Value | |
Bromelain (2,000 G.D.U.* per gram) | 500 mg | † |
†Daily Value not established. *G.D.U. (Gelatin Digesting Units) is a standard measure of activity for bromelain. |
Bromelain is a pineapple digestive enzyme (breaks down proteins)
with a wide pH range, which can function within the acidic environment of
the stomach.
Supplement Facts:
Bromelain (2,000 G.D.U.* per gram) 500 mg
* Gelatin Digesting Units
Other products sold online
Now Foods, Quercetin with Bromelain, 240 Veg Capsules
Suggested Use and dosage: 1or 2 bromelain tablets daily or
as suggested by your health care provider. If you have a delicate, easily irritated stomach, take with
meals.
GDU is a standard measure of activity.