Calcium D Glucarate supplement research and health benefit, using the right dosage and review of published trials
April 1 2018 by
Ray Sahelian, M.D.

D-glucarate is the anionic form of D-glucaric acid. It is naturally found in some vegetables and fruits, including cruciferous vegetables, bean sprouts and apples. D-glucarate in the form of its calcium salt, is marketed as a nutritional supplement.
   D-glucono-1,4-lactone, sodium D-gluconate and calcium D-glucarate are non-toxic glucose derivatives occurring naturally in fruits and vegetables. Calcium D-glucarate is promoted as an orally bioavailability dietary supplement with potential health benefits without major side effects. Despite many commercial applications in pharmaceutical and food industries the potential health benefits of glucarate and gluconate are still not well understood.

Food source, in the diet
Calcium Glucarate is a naturally occurring non-toxic compound present in fruits, vegetables and seeds of some plants. Dietary calcium glucarate, a sustained-release from of glucarate, elevates the blood level of D-glucaro-1,4-lactone which suppresses blood and tissue beta-glucuronidase activity.

Benefit as a supplement
Oral supplementation inhibits beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated wire an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers.

Gilbert's disease, liver health
Q. I was recently diagnosed with Gilbert's Syndrome. It's a hereditary defect where my liver lacks the enzyme to properly detoxify bilirubin, so it is left in my bloodstream and leaves a yellow tint in my eyes. Would you recommend Calcium-D Glucarate to help the detoxification process? I have researched it heavily, but wanted the opinion of a M.D.
   A. I am not aware of such research so, at this time, I don't know whether it would help, hurt, or have no effect.

Lung cancer
Oncology Letters. 2011. Dietary D-glucarate effects on the biomarkers of inflammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Dietary D-glucarate decreases the level of proinflammatory cytokines, increases the level of the anti-inflammatory cytokine IL-10 during early post-initiation stages of B[a]P-induced lung tumorigenesis in A/J mice and affects apoptotic induction.

As of 2017 I could not find any human studies with calcium d glucarate to determine the effectiveness of this natural supplement in terms of prevention or treatment of cancer. Until such studies are done, we can only guess at the effectiveness of this supplement, and even if it works, a lot of research needs to be done to determine what the ideal dosage would be and how long this nutrient needs to be used.

Testosterone influence
Do you know or has there been any studies on what effect calcium d glucarate has on testosterone levels in men? Does it help or hurt the free testosterone. I would think that by removing estrogens and toxins it would help the testosterone level, but then again testosterone is also removed by glucuronidation? I personally have been taking it for a few weeks for detox and it seems my sex drive is increasing as well.
    We searched Medline in 2013 and did not find any studies regarding the influence of calcium d glucarate on testosterone levels.

I am a medical doctor. If I have someone taking a male supplement to boost testosterone, will the d-Glucarate boost the effect of the supplement or also pull the extra testosterone out of the system the supplement is producing along with estrogen? If the latter, I would gather they should be taken far apart in the day, correct?
    These are questions that are difficult to answer since hardly any studies have been done with the use of calcium d glucarate supplements.

Source Naturals, purchase Calcium D-Glucarate, 500 mg each pill
Source Naturals Calcium D-Glucarate has been shown to enhance the major detoxification pathways in the body. This nutrient is found naturally in the human body and in a variety of fruits and vegetables. Animal studies have shown that it inhibits B-glucuronidase, thereby enhancing the process of glucuronidase, in which foreign organic compounds, fat-soluble toxins and excess steroid hormones such as estrogen are detoxified and excreted from our bodies.

Purchase Calcium d-glucarate product