Ciwujia extract by Ray Sahelian, M.D.
April 8 2015

Arthritis and inflammation
Phytother Res. 2014. Prophylactic and therapeutic effects of Acanthopanax senticosus Harms extract on murine collagen-induced arthritis.

Blood sugar and diabetes
Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats.
Clin Exp Pharmacol Physiol. 2005.
1. In an attempt to develop new substances for handling insulin resistance, an aqueous extract of the root of Acanthopanax senticosus ( ciwujia ) was used to screen the effect on insulin resistance induced by fructose-rich chow in rats. 2. Insulin action on glucose disposal rate was measured using the glucose-insulin index, the product from areas under the curve of glucose and insulin during the intraperitoneal glucose tolerance test. In addition to the modification of feeding behaviour and a marked decrease in bodyweight, oral administration (three times daily for 3 days) of the aqueous extract of ciwujia root to rats that had received fructose-rich chow for 4 weeks reversed the elevated value of the glucose--insulin index, indicating that this herb has the ability to improve insulin sensitivity. 3. Time for the loss of the plasma glucose-lowering response to tolbutamide (10.0 mg/kg, i.p.) in fructose-rich chow-fed rats was markedly delayed by repeated treatment with the aqueous extract of A. senticosus root compared with the vehicle (saline) -treated group. Thus, an improving effect of A. senticosus root on insulin resistance can be considered. 4. An increase in insulin sensitivity following the administration of this herb was further identified using the plasma glucose-lowering action of exogenous insulin in streptozotocin (STZ)-diabetic rats. Oral administration of the aqueous extract of ciwujia root at a dose of 150.0 mg/kg three times daily to STZ-diabetic rats increased the responses to exogenous insulin 10 days later. 5. The results obtained suggest that oral administration of the aqueous extract from ciwujia root has the ability to improve insulin sensitivity and delay the development of insulin resistance in rats and, thus, may be used as an adjuvant therapy for patients with insulin resistance.

Chemical Composition of ciwujia herb
Monoterpenes and sesquiterpenes, hyperin are contained within the herb.

A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects.
Phytomedicine. 2005. Mkrtchyan A, Panosyan V, Panossian A.
Republican Medical Scientific Centre of Dermatology and Diseases Disseminated by Sexual Contacts, Yerevan, Armenia.
The safety of different doses of Kan Jang--a fixed combination of Andrographis paniculata special extract (SHA-10) and Acanthopanax senticosus -- compared to two extensively used medicinal plants, Valeriana officinalis and Panax ginseng in the form of standardized extracts, has been examined. A phase I clinical study was designed to evaluate the effect on semen quality of healthy males in terms of spermatogenesis and quality of semen. The results of the study revealed no significant negative effect of Kan Jang on male semen quality and fertility, but rather a positive trend with respect to the number of spermatozoids in the whole ejaculate, the percentage of active (normokinetic) forms of spermatozoids, and fertility indexes, together with a decrease in the percentage of inactive (diskinetic) forms of spermatozoids. In the group receiving ginseng, no significant negative effects on the fertility parameters were revealed and there was a clear decrease in the percentage of diskinetic forms of spermatozoids. Subjects receiving valerian showed a temporary increase in the percentage of normokinetic spermatozoids and a decrease in diskinetic forms, but these changes had no effect on fertility indices. The results indicate that Kan Jang, ginseng and valerian are safe with respect to effects on human male sterility when administered at dose levels corresponding to approximately 3 times the human daily dose.

Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer]
Zhongguo Zhong Yao Za Zhi. 2005.
Department of Pharmacology, Hubei Institute for Nationalities, Enshi 445000, China.
To study the effect of Acanthopanax senticosus injection (ASI) on the activities of human tumor necrosis factor (TNF) and natural killer cell (NKC) in the patients with lung cancer and the underlying mechanism. 73 cases with lung cancer were randomly divided into two groups, namely, the treatment group and observation group; 61 cases with or without other diseases were respectively divided into control A and B groups. The patients in treatment group were injected with ASI for 21 days. The activities of human TNF and NKC and the levels of IgG, IgA and IgM were detected respectively. After injection with ASI the activity of TNF-alpha in treatment group was comparable with that in the two control groups and was significant lower that that in observation group. The activity of TNF-beta and the levels of IgA, IgG and IgM were significantly higher than those in observation group and two control groups. The activity of NKC was also remarkably higher than observation and two control groups. Ciwujia can regulate the cellular immunity and factor, indicating that ciwujia can be used as an assistant drug to regulate the function of cellular immunity in the patients with lung cancer.

Acanthopanax senticosus extract - ciwujia - prepared from cultured cells decreases adiposity and obesity indices in C57BL/6J mice fed a high fat diet.
J Med Food. 2004.
Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University, Chonju, Republic of Korea.
The herb Acanthopanax senticosus was cultured from a cell suspension by a proprietary process, and evaluated for protective effects against obesity in C57BL/6J mice fed high fat diets. Forty 4-week-old male C57BL/6J mice were fed either a normal diet (10 kcal fat%) or high fat diet (60 kcal fat%) given with or without oral administration of A. senticosus extract for 12 weeks. Feed consumption was not different among the groups, but energy intake was higher in the groups fed high fat diets than in the groups fed normal diets. Body weight gain, abdominal fat accumulation, and serum leptin concentrations were significantly higher in the high fat-fed groups than the other groups. Animals fed the high fat diet had significantly higher low-density lipoprotein (LDL)-cholesterol in serum and higher triglyceride accumulation in liver, but the ASE supplement restored both to the same levels as in the animals fed low fat diets. Total carnitine concentration were not significantly different between the two diet groups; also the oral administration of ASE did not alter carnitine status. Accordingly, the current results suggest the oral administration of ASE seemed to lower the weight gain, serum LDL-cholesterol concentration, and liver triglycerides accumulation in mice with obesity induced by high fat diets. These results seemed to suggest that supplementation with ASE might have a role in the prevention of obesity in high fat-fed mice.

Email received 2009
Thank you for making so much helpful information available on your website. Are you aware that Ciwujia (Chinese Ci Wu Jia) and Siberian ginseng are one and the same? Your Ginseng page mentions Siberian ginseng among the other ginsengs. As you know, Siberian ginseng is not really considered a Ginseng. As I understand it, that is why the US authorities do not permit the sale of Ciwujia under the name Siberian Ginseng. It might be helpful to acknowledge on your Ciwujia page that this supplement (Eleutherococcus senticosus) is sold under the name Siberian ginseng in many countries, and also sometimes as Eleuthero. The research data on Siberian ginseng should equally apply to what is sold in the US as Ciwujia, or under the trade name Endurox.
    Thanks for your email, we will look into this.