CMO supplement for arthritis benefit, dosage and side effects - does it help with arthritis pain?
December 1 2017 by Ray Sahelian, M.D. Review of research studies, 400 mg capsules

Cetyl myristoleate is the common name for cis-9-cetyl myristoleate, a compound made in the body of humans and certain animals by the combination of cetyl alcohol and mysristoleic acid. The rational for the use of CMO is that it may inhibit the production of inflammatory prostaglandins and leukotrienes. CMO is a natural medium chain fatty acid found in certain animals, including cows, whales, beavers, and mice. As a nutritional supplement it is extracted in a highly purified from beef tallow and then placed in capsules and tablets. CMO is also available in creams and lotions for topical application.
   CMO was discovered in 1972 by Harry W. Diehl, Ph.D., a researcher at the National Institutes of Health. At the time, Dr. Diehl was responsible for testing anti-inflammatory drugs on lab animals. In order for him to test the drugs, he first had to artificially induce arthritis in the animals by injecting a heat-killed bacterium called Freund’s adjuvant. Dr. Diehl discovered that Swiss albino mice did not get arthritis after injection of Freund’s adjuvant. Eventually, he was able to determine that cetyl myristoleate CMO was the factor present naturally in mice that was responsible for this protection. When CMO was injected into various strains of rats, it offered the same protection against arthritis. It has been proposed that it acts as a joint “lubricant” and anti-inflammatory agent.

Advance Physician Formulas, Inc., CMO, 550 mg, 60 Capsules
Buy CMO 550 mg each pill, 60 Capsules

Cetyl Myristoleate Fatty Acid Complex for Joints, from beef tallow

CMO contains concentrated extract of the fatty acid cerasomal-cis-9-acetyl-myristoleate from natural bovine source. It is not found in any vegetable oils or other common foods but is found in low amounts in animal connective tissue.

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Supplement Facts Physician Formulas, Inc., CMO
Serving Size: 1 Capsule
Servings Per Bottle: 60 Capsules
  Amount Per Capsule % DV
Cetyl Myristoleate Complex (20% Cetyl myristoleate, Yielding 110 mg) 550 mg
† Daily Value or Recommended Daily Intake not established.

Usage, dosage: Take 1 CMO capsule daily in the morning, or as directed by your qualified health consultant.
Supplement Facts: Cetyl Myristoleate Extract 550 mg per pill, Fatty Acid Complex
Buy CMO supplement, Joint Power Rx with msm, chondroitin, glucosamine and turmeric extract, or to sign up to a FREE newsletter

Joint Power Rx has several herbal extracts and nutrients that play a role in joint health:
Glucosamine sulfate (from shellfish)
Chondroitin sulfate
CMO complex
Boswellia serrata extract
Cat's claw extract
Devil's claw extract
Grape seed extract
Sea Cucumber

CMO side effects, safety, toxicity, is it safe?
I could not find adverse events reported in medical journals as of 2016, if you have experienced any adverse reactions or any type of unpleasant side effects, let me know.

I have suffered and managed lower back pain for 21 years now, first with a bulging disc that herniated after 10 years, and a diagnosis of arthritis at 35. Physical therapy exercises, traction, and recently acupuncture have all been helpful. I eat very healthfully, consuming raw greens daily, raw nuts in moderation daily, plain Greek yogurt with cinnamon, moderate amounts of fruit, fish and chicken, and lots of green tea and water. I read an article about CMO elsewhere and started taking it with almost immediate positive results, however, my body reacted by becoming stopped up. I went to Urgent Care with intense pain within 24 hours of taking it and X-ray confirmed the problem. I stopped the CMO and got a cream instead, which also has been very effective and now I am trying to reintroduce the CMO at a slower pace, hoping I can take it for at least 30 days to get the long-term effects I have read about. I found your comments about CMO with no negative effects reported, so I thought I would pass it along to others. I take many supplements, and I have never had this kind of reaction before. I phoned poison control out of curiosity, but they had never heard of CMO. Hopefully, I can manage the oral pills; time will tell. Thank you for all of your helpful information!

Dosage, how to take
I have been using CMO products for the past few months now with great success. Is it better to take it with or without food?
    A. Most of the time supplements are better absorbed on an empty stomach, but they are well absorbed with food, too, so it may not make much of a difference, however, studies have not been done comparing the two approaches, hence it is difficult to predict which option is better. For the time being a good compromise is to take it a few minutes before food.

CMO arthritis research study
As of 2017, I have not come across any new human research in the past several years.

People with the wear-and-tear kind of arthritis of the knee may benefit from a proprietary cream containing a blend of cetylated fatty acids. Pain relief and improved functional performance may be experienced as early as half an hour after the cream is applied to the affected joint.

Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.
Pharmacol Res. 2003. University of Nevada School of Medicine, Reno, NV
Cetyl myristoleate was reported by Diehl and May to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CMO and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. CMO administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties.

Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats.
J Pharm Sci 1994. Diehl HW, May EL. Department of Pharmacology, Medical College of Virginia, Richmond.
CMO was isolated from Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. In limited comparisons, cetyl oleate, also found in Swiss albino mice, gave lesser protection, whereas cetyl myristate and cetyl elaidate, the trans-isomer of cetyl oleate, appeared to be virtually ineffective. Dosage of the protective compound as well as the site of injection of Freund's adjuvant was important.

Thyroid gland
Q. I have been reading a book highly recommended to me "Arthritis Beaten Today!" by Dr. Len Sands, and have found it the scientific explanation very interesting of the mechanism of how the cells go on to attack healthy cartilage. I have arthritis in my spine (and there is a history of it in my family) and was impressed by the high recommendation of the supplement CMO. The book mentions that it would address many autoimmune diseases. So, I was wondering if it might also address hypothyroidism which I have had for many years, in which I take Levothyroxin.
   A. Since there are hardly any human studies with CMO supplements, let alone in cases of arthritis, autoimmune diseases, or thyroid disease, it is very difficult to predict what kind of effect supplementation would have, if any, on these conditions.

Use in pets, cats, dogs, horses
Is CMO 400 mg safe to give to a dog?
   I have not found any major studies evaluating this substance in a dog or other animals, however it seems most animals tolerate supplements as humans but usually at a smaller dose.

I am a registered massage therapist in British Columbia, Canada. I have recently tried your CMO product for my own chronic lumbar degenerative disc disease. I am certainly impressed with the results! I tried going without it after my 1st bottle was finished, and the symptoms returned over a week. I then re-ordered, and am now back on the product, feeling great again. I want to try the Joint Power Rx compound next. If it is as successful as the CMO, I seriously want to look at providing this product to my patients.

I just wanted to let you know that CMO has completely removed my arthritis pain. I had been taking cat's claw and cucurmin, with little result. After only one week of taking CMO 1,1000mg a day the pain had gone. I took it for a couple of months, then read a study which said to only take for a month - but at a higher dose. I have stopped it now, several weeks ago, and no return of the pain. Before that it was difficult to reverse the car, as I could hardly turn my neck, it was so painful. I still continue with the cucurmin and cat's claw and take fish oil. The study also said to eliminate several things, including alcohol and fruit juice. I hadn't read it, so still had my two glasses of wine at night and occasional juice. It worked anyway. This is the first time ever that I can say I definitely felt an improvement with ANY supplement. Most of them I take in the hope that they will keep me healthy as I grow older!

I have been taking 550 mg of CMO every day for at least 7 years. The vitamin shop did not tell me there was limit. I have severe bloating. Could this be causing it? It does help my arthritis.
   A. I am not sure.

I wrote to you some time ago saying how much success I had with CMO relieving arthritis pain. I recently had a very stiff, swollen, painful finger, which I haven't had for years. Time for another course of CMO - it's been 10 months since I last took it. As last time, the pain and swelling was relieved in 3-4 days.

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