May 1 2015
Effects of a high molecular mass Convolvulus arvensis extract on tumor growth and angiogenesis.
P R Health Sci J. 2002. Meng XL, Riordan NH, Casciari JJ, Zhu Y, Zhong J, González MJ. Bio-Communications Research Institute, Center for the Improvement of Human Functioning, 3100 North Hillside Avenue, Wichita, KS, USA.
Plant materials represent promising sources of anti-cancer agents. We developed and tested a novel extract from the ubiquitous plant Convolvulus arvensis. Convolvulus arvensis components were extracted in boiling water, and small molecules were removed by high-pressure filtration. The extract's biological activity was assessed by measuring its effects on S-180 fibrosarcoma growth in Kun Ming mice and on heparin-induced angiogenesis in chick embryos. We also examined the extract's effects on lymphocytes ex vivo and tumor cell growth in vitro. The extract (primarily proteins and polysaccharides) inhibited tumor growth in a dose-dependent fashion when administered orally. At the highest dose tested, 200 mg/kg/day, tumor growth was inhibited by roughly seventy percent. Subcutaneous or intraperitoneal administration at 50 mg/kg/day also inhibited tumor growth by over seventy percent. The extract's acute LD50 in Kun Ming mice was 500 mg/kg/day when injected, indicating that tumor growth inhibition occurred at non-toxic doses. It inhibited angiogenesis in chick embryos, improved lymphocyte survival ex vivo, and enhanced yeast phagocytosis, but did not kill tumor cells in culture. High molecular mass extract deserves further study as an anti-cancer agent.
J Complement Integr Med. 2014. A study to investigate the biological activity of proteoglycan mixture extract from Convolvulus arvensis. Convolvulus arvensis, bindweeds, is inhabitant to Iran and its proteoglycan mixture (PGM) has been reported to possess different biological activities. In the present study, we aimed to investigate different properties of PGM including anti-tumor, anti-angiogenesis and immunostimulatory activities. The present study provides some new evidence on remarkable leishmanicidal and anti-angiogenic activities of PGM. These findings also afford the scientific basis for the use of C. arvensis as a candidate medicinal plant for further thoroughly phytochemical investigations toward discovering leishmanicidal and anti-angiogenic compounds.
I'm an herbalist in Israel and like to research about plants for helping people. i wonder what you think about the botanical herb Convolvulus Arvensis.
I have not studied this herb in any detail.