Some flavones include:
Acacetin, a natural flavone, selectively inhibits human atrial
repolarization potassium currents and prevents atrial fibrillation in
dogs.
Chrysin is a natural, biologically active
flavone extracted from many
plants, honey and propolis.
Hyperoside is a
flavone found in many herbs including cuscuta herb.
Luteolin is an important flavone, which is found in several plant
products, including broccoli, pepper, thyme, and celery. Numerous
studies have shown that luteolin possesses beneficial neuroprotective
effects both in vitro and in vivo.
Liver protection formula
J Young Pharm. 2013. Design and evaluation of herbal hepatoprotective formulation against paracetamol induced liver toxicity.
To isolate and identify the quercetin from polyherbal hepatoprotective
formulation. Polyherbal formulations were developed by using five
bioactive fractionated extracts of Butea monosperma, Bauhinia variegata
and Ocimum gratissimum for treatment of liver disorders by exploiting
the knowledge of traditional system of medicine and evaluated for
hepatoprotective activity using acute liver toxicity model of
paracetamol induced liver damage in rats. Biochemical marker showed
improved results for polyherbal tablet formulation at 100 mg/kg.
Polyherbal tablet formulation contains a potent hepatoprotective agent
suggested to be a flavone concentrated in polyherbal formulation which
may find clinical application in amelioration of paracetamol induced
liver damage.
Vitamin C 15
mg (Ascorbic acid)
Citrus bioflavonoids (eriocitrin,
hesperidin,
flavonols,
flavones,
flavonoids, naringenin, and
quercetin)
Mixed carotenoids (alpha carotene,
astaxanthin,
beta carotene, cryptoxanthin,
Lutein,
Lycopene,
Zeaxanthin)
Bilberry
extract (Vaccinium myrtillus)
Eyebright
extract (Euphrasia officianales)
Ginkgo biloba
(Ginkgo biloba)
Mucuna pruriens
extract (Cowhage)
Cinnamon (Cinnamomum zeylanicum)
Lycium berry extract (Lycium Barbarum) - also known as
Goji Berry
Sarsaparila (Sarsaparilla Smilax)
Alpha Lipoic acid
antioxidant
Flavones in Sytrinol supplement
Sytrinol is
patented formula that has polymethoxylated flavones found in oranges,
tangerines and palm fruit extracts. Sytrinol is marketed as promoting
healthy cholesterol and triglyceride levels.
Erectile dysfunction, impotence
Eating foods that are rich in certain
flavonoids may reduced the risk of erectile dysfunction in men, especially those
under 70, according to research from Harvard University and the University of
East Anglia published in The American Journal of Clinical Nutrition, 2016. Of
the different flavonoids, anthocyanins (found in blueberries, cherries,
blackberries, radishes and blackcurrant), and flavanones and flavones (found in
citrus fruits) were found to offer the greatest benefits in preventing the
condition.
Research
Vascular and anti-oxidant actions of flavonols and flavones.
Clinical Exp Pharmacol Physiology. 2004.
Flavonols and flavones are plant-derived polyphenolic compounds that are
commonly consumed in the diet. Epidemiological studies indicating that high
dietary intake of flavonols reduces the risk of mortality due to coronary heart
disease have provoked interest in the mechanism of this cardioprotective effect.
We have investigated the structure-activity relationships of a range of flavonols and flavones with regard to their vascular relaxant and anti-oxidant
activity. In rat isolated thoracic aorta, the synthetic flavonol
3',4'-dihydroxyflavonol (DiOHF) was found to be a significantly more potent
vasorelaxant than the naturally occurring compounds chrysin, apigenin, luteolin,
quercetin and fisetin. Similarly, DiOHF was significantly more potent than those
compounds in the inhibition of calcium-induced contraction of the rat aorta. 3.
3',4'-Dihydroxyflavonol was also found to significantly inhibit superoxide
radical generation in a cell-free system in the presence of xanthine/xanthine
oxidase or by rat isolated aorta in the presence of NADPH. In the presence of
oxidant stress generated by pyrogallol or xanthine/xanthine oxidase,
endothelium-dependent relaxation of rat aortic rings was impaired.
3',4'-Dihydroxyflavonol was able to significantly improve endothelium-dependent
relaxation in the presence of those oxygen radical generators. 4. In addition,
DiOHF was found to significantly improve dilatation in the rat hindquarters
vasculature after exposure to ischaemia and reperfusion. 3',4'-Dihydroxyflavonol
was found to be equally effective whether applied before ischaemia or during
ischaemia just before reperfusion. 5. In conclusion, DiOHF is an effective
vasodilator and anti-oxidant that is able to prevent vascular reperfusion
injury. We suggest that DiOHF may be useful as an adjunct to thrombolytic
therapy in the management of reperfusion injury.
Vasorelaxing effects of flavonoids: investigation on the possible
involvement of potassium channels.
Naunyn Schmiedebergs Arch Pharmacol. 2004.
A flavonoid-rich diet has been associated with a lower incidence of
cardiovascular diseases, probably because of the antioxidant and vasoactive
properties of flavonoids. Indeed, many flavonoids show vasorelaxing properties,
due to different and often not yet completely clarified mechanisms of action.
Among them, the activation of vascular potassium channels has been indicated as
a possible pathway, accounting, at least in part, for the vasodilatory action of
some flavonoid derivatives, such as apigenin and dioclein. Therefore, this work
aims at evaluating, on in vitro isolated rat aortic rings, the
endothelium-independent vasorelaxing effects of a number of flavonoid
derivatives, to identify a possible activation of calcium-activated and/or
ATP-sensitive potassium channels and to indicate some possible
structure-activity relationships. Among the several flavonoids submitted to the
pharmacological assay, only baicalein and quercetagetin were almost completely
ineffective, while quercetin, hesperidin, quercitrin and rhoifolin exhibited
only a partial vasorelaxing effect. On the contrary, acacetin, apigenin, chrysin,
hesperetin, luteolin, pinocembrin, 4'-hydroxyflavanone, 5-hydroxyflavone,
5-methoxyflavone, 6-hydroxyflavanone and 7-hydroxyflavone, belonging to the
chemical classes of flavones and flavanones, showed full vasorelaxing effects.
The vasodilatory activity of hesperetin, luteolin, 5-hydroxyflavone and
7-hydroxyflavone were antagonised by tetraethylammonium chloride, indicating the
possible involvement of calcium-activated potassium channels. Moreover,
iberiotoxin clearly antagonised the effects of 5-hydroxyflavone, indicating the
probable importance of a structural requirement (the hydroxy group in position
5) for a possible interaction with large-conductance, calcium-activated
potassium channels. Finally, glibenclamide inhibited the vasorelaxing action of
luteolin and 5-hydroxyflavone, suggesting that ATP-sensitive potassium channels
may also be involved in their mechanism of action.
Flavoxine is a blend of two plant extracts, a proprietary extract of Phellodendron amurense and a patented extract of orange peel containing polymethoxylated flavones.