Gamma Oryzanol is found in rice bran oil and other plants. It is a unique mixture of triterpene alcohol and sterol ferulates.
Summary and review
Gamma-oryzanol is extracted from rice bran oil and has a wide spectrum of
biological activities; in particular, it has antioxidant properties and
is often used in cosmetic formulations as a sunscreen. It may have beneficial effects on
cholesterol.
Antioxidant benefit
Antioxidant activity of gamma-oryzanol: mechanism
of action and its effect on oxidative stability of pharmaceutical oils.
Int J Pharm. 2005.
The first objective of the present investigation was to elucidate the
molecular mechanism(s) of the antioxidant activity of gamma-oryzanol by
utilising different in vitro model systems, such as scavenging of stable
DPPH radical, OH and O2- radicals scavenging, and azocompound AMVN-initiated
lipid peroxidation. The effect of gamma-oryzanol on the oxidative
stability of vegetable oils of pharmaceutical and cosmetic interest was
then evaluated in a oxidation accelerate test and compared with the effect
of the well-known antioxidants BHA and BHT. Our results demonstrate that
gamma-oryzanol is an organic radical scavenger able to prevent AMVN-triggered
lipoperoxidation. Moreover, when added to oils at concentrations ranging
between 2.5 and 10 mmol/kg, gamma-oryzanol shows a dose-dependent increase
of the induction times; in particular, it improved the oxidative stability
of oils very prone to lipoperoxidation because of their high content of
polyunsaturated fatty acids. On the ground of our results, we can conclude
that gamma-oryzanol may have a potential application for the stabilization
of lipidic raw materials.
Prevention of brain protein and lipid oxidation
elicited by a water-soluble oryzanol enzymatic extract derived from rice
bran.
Eur J Nutr. 2003.
The antioxidant capacity of rice bran (due mainly to its gamma-oryzanol
content) is very well known. We have recently developed a water-soluble
gamma oryzanol enzymatic extract, which shows a greatly increased
functionality. The aim of our study is the evaluation of
the antioxidant potential of gamma oryzanol enzymatic extract in an ex
vivo model to compare its protective capacity against oxidative damage by
active-oxygen substances and free radicals (mainly the peroxyl radical) to
biomolecules (such as proteins and lipids) with that of antioxidants, such
as Trolox (a water-soluble derivative of vitamin E), melatonin, and folic
acid. Gamma oryzanol enzymatic extract is a new potential
antioxidant agent from rice bran that shows a high free-radical-scavenging
capacity and prevents protein oxidation and lipid peroxidation when cells
ex vivo are exposed to free radicals.
Cholesterol and blood lipids
Eur Rev Med Pharmacol Sci. 2012. Effect of gamma-oryzanol on the
bioaccessibility and synthesis of cholesterol. The cholesterol lowering activity
of gamma-OR is due in part to impaired apical uptake of cholesterol into
enterocytes and perhaps a decrease in HMG-CoA reductase activity.
Similar cholesterol-lowering properties of rice
bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men.
Eur J Nutr. 2005.
The cholesterol lowering properties of rice bran oil containing
differing amounts of non-saponifiable components have not been studied in
humans, to our knowledge. To evaluate cholesterol lowering effects of rice
bran oil, with low and high amounts of gamma-oryzanol (ferulated plant
sterols) in mildly hypercholesterolemic men. Rice bran oil
supplementation at ca. 50% total fat intake improved lipoprotein pattern
in mildly hypercholesterolemic men. Methylated sterols in gamma-oryzanol
are thought to be largely ineffective at inhibiting dietary cholesterol
absorption, but could enhance cholesterol-lowering ability of
4-desmethylsterols. Assuming all ferulated sterols become de-ferulated in
the gut, low and high gamma-oryzanol containing rice bran oil provided
intestinal loads of 453 and 740 mg/d free 4-desmethylsterols,
respectively. This intestinal load of 453-740 mg/d of efficacious free
plant sterol equivalents had identical effects on lipoproteins.
Rice bran oil and gamma-oryzanol in the treatment
of hyperlipoproteinaemias and other conditions.
Phytother Res. 2001.
Diet is the first (and sometimes the only) therapeutic approach to
hyperlipoproteinaemias. Rice bran oil and its main components (unsaturated
fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol)
have demonstrated an ability to improve the plasma lipid pattern of
rodents, rabbits, non-human primates and humans, reducing total plasma
cholesterol and triglyceride concentration and increasing the high density
lipoprotein cholesterol level. Other potential properties of rice bran oil
and gamma-oryzanol, studied both in vitro and in animal models, include
modulation of pituitary secretion, inhibition of gastric acid secretion,
antioxidant action and inhibition of platelet aggregation. This paper
reviews the available data on the pharmacology and toxicology of rice bran
oil and its main components with particular attention to those studies
relating to plasma lipid altering effects.
Hair growth
Biol Pharm Bull. 2014. In vivo hair growth-promoting effect of rice bran
extract prepared by supercritical carbon dioxide fluid. The potential hair
growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and
major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol,
were evaluated with the histological morphology and mRNA expression levels of
cell growth factors using real-time reverse transcriptase-polymerase chain
reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to
a similar extent as 3% minoxidil, showing that the hair follicles were induced
to be in the anagen stage. The numbers of the hair follicles were significantly
increased. In addition, mRNA expression levels of vascular endothelial growth
factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth
factor (KGF) were also significantly increased and that of transforming growth
factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components
of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles
according to examination of histological morphology and mRNA expression levels
of cell growth factors. In conclusion, our results demonstrate that RB-SCE,
particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests
RB-SCE can be applied as hair loss treatment.
Immunity
Increased immune response in mice consuming rice
bran oil.
Eur J Nutr. 2005.
Polyunsaturated fatty acids play a key role in a number of biological
functions. Rice bran oil is rich in linoleic acid, an essential n-6 fatty
acid. n-6 fatty acids are said to have proinflammatory effects as a result
of an increase in n-6 fatty acidderived eicosanoids. Rice bran oil is also
rich in gamma-oryzanol, a compound from the unsaponifiable fraction, with
antioxidant properties. Our results suggest that although gamma-oryzanol
may modulate the immune system, it is not responsible for the overall
immunostimulation effect. Rice bran
oil -enriched diets could be useful in situations where a potentiation of
the immune response was required. The fatty acids composition, more than
the unsaponifiable fraction, might be responsible for this effect.
Physical endurance, muscle strength
The effects of gamma-oryzanol supplementation
during resistance exercise training.
Int J Sport Nutr. 1997
To determine the effectiveness of gamma-oryzanol supplementation,
weight-trained males were randomly divided into supplemented (G-O) and
control placebo (Con) groups. The G-O group ingested 500 mg.day-1 of
gamma-oryzanol according to manufacturer's instructions. Test batteries
were administered before (T1), after 4 weeks (T2), and after 9 weeks (T3)
of a periodized resistance exercise program. Both groups demonstrated
significant increases in 1 repetition maximum muscular strength (bench
press and squat) and vertical jump power, with no differences between the
groups. No differences between groups were observed for measures of
circulating concentrations of hormones (testosterone, cortisol, estradiol,
growth hormone, insulin, beta-endorphin), minerals (calcium, magnesium),
binding protein (albumin), or blood lipids (total cholesterol,
triglycerides, HDL-cholesterol). Resting cardiovascular variables
decreased similarly for both groups. These data suggest that 9 weeks of
500 mg.day-1 of gamma-oryzanol supplementation does not influence
performance or related physiological parameters in moderately
weight-trained males.
Indian J Med Res. 2014. Effects of gamma oryzanol supplementation on anthropometric measurements & muscular strength in healthy males following chronic resistance training. Enhanced muscle strength is seen when resistance exercise is combined with the consumption of nutritional supplements. Although there is a limited number of studies available about the efficacy of gamma oryzanol supplementation with resistance exercise in humans, but its usage as a nutritional supplement for strength is common in athletes. The aim of this study was to determine the effects of gamma oryzanol supplementation during 9-week resistance training on muscular strength and anthropometric measurements of young healthy males. Our findings indicated that 600 mg/day gamma oryzanol supplementation during the 9-week resistance training did not change anthropometric and body measurements, but it increased muscular strength in young healthy males. Further, studies need to be done in trained athletes, women, and in patients who suffer from muscular fatigue.
Emails
Can I take a gammaoryzanol supplement the same day as
serrapeptase or
mangosteen?
You can probably take it with mangosteen, but there
is not enough known about serrapeptase to know for sure.
Source Naturals - buy Gamma Oryzanol,
60 mg, 100 Tablets
Supplement Facts:
Calcium 23 mg 2 %
Gamma-oryzanol 60 mg
Buy Gamma Oryzanol
Supplement Facts for Source Naturals Gamma Oryzanol | ||
Serving Size: 1 Tablet | ||
Amount Per Serving | %DV | |
Calcium | 23 mg | 2% |
gamma-Oryzanol | 60 mg | † |
†Daily Value not established |
Buy Gamma-Oryzanol
pills
Suggested Use: Men - 1 to 3 tablets; Women - 1 or 2 tablets. Take once daily,
preferably on an empty stomach (3 or more hours after a meal).