Gamma Oryzanol supplement benefit and side effects, medical uses, dosage
September 26 2016
by Ray Sahelian, M.D.

Gamma Oryzanol is found in rice bran oil and other plants. It is a unique mixture of triterpene alcohol and sterol ferulates.

Summary and review
Gamma-oryzanol is extracted from rice bran oil and has a wide spectrum of biological activities; in particular, it has antioxidant properties and is often used in cosmetic formulations as a sunscreen. It may have beneficial effects on cholesterol.

Antioxidant benefit
Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils.
Int J Pharm. 2005.
The first objective of the present investigation was to elucidate the molecular mechanism(s) of the antioxidant activity of gamma-oryzanol by utilising different in vitro model systems, such as scavenging of stable DPPH radical, OH and O2- radicals scavenging, and azocompound AMVN-initiated lipid peroxidation. The effect of gamma-oryzanol on the oxidative stability of vegetable oils of pharmaceutical and cosmetic interest was then evaluated in a oxidation accelerate test and compared with the effect of the well-known antioxidants BHA and BHT. Our results demonstrate that gamma-oryzanol is an organic radical scavenger able to prevent AMVN-triggered lipoperoxidation. Moreover, when added to oils at concentrations ranging between 2.5 and 10 mmol/kg, gamma-oryzanol shows a dose-dependent increase of the induction times; in particular, it improved the oxidative stability of oils very prone to lipoperoxidation because of their high content of polyunsaturated fatty acids. On the ground of our results, we can conclude that gamma-oryzanol may have a potential application for the stabilization of lipidic raw materials.

Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran.
Eur J Nutr. 2003.
The antioxidant capacity of rice bran (due mainly to its gamma-oryzanol content) is very well known. We have recently developed a water-soluble gamma oryzanol enzymatic extract, which shows a greatly increased functionality. The aim of our study is the evaluation of the antioxidant potential of gamma oryzanol enzymatic extract in an ex vivo model to compare its protective capacity against oxidative damage by active-oxygen substances and free radicals (mainly the peroxyl radical) to biomolecules (such as proteins and lipids) with that of antioxidants, such as Trolox (a water-soluble derivative of vitamin E), melatonin, and folic acid. Gamma oryzanol enzymatic extract is a new potential antioxidant agent from rice bran that shows a high free-radical-scavenging capacity and prevents protein oxidation and lipid peroxidation when cells ex vivo are exposed to free radicals.

Cholesterol and blood lipids
Eur Rev Med Pharmacol Sci. 2012. Effect of gamma-oryzanol on the bioaccessibility and synthesis of cholesterol. The cholesterol lowering activity of gamma-OR is due in part to impaired apical uptake of cholesterol into enterocytes and perhaps a decrease in HMG-CoA reductase activity.

Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men.
Eur J Nutr. 2005.
The cholesterol lowering properties of rice bran oil containing differing amounts of non-saponifiable components have not been studied in humans, to our knowledge. To evaluate cholesterol lowering effects of rice bran oil, with low and high amounts of gamma-oryzanol (ferulated plant sterols) in mildly hypercholesterolemic men. Rice bran oil supplementation at ca. 50% total fat intake improved lipoprotein pattern in mildly hypercholesterolemic men. Methylated sterols in gamma-oryzanol are thought to be largely ineffective at inhibiting dietary cholesterol absorption, but could enhance cholesterol-lowering ability of 4-desmethylsterols. Assuming all ferulated sterols become de-ferulated in the gut, low and high gamma-oryzanol containing rice bran oil provided intestinal loads of 453 and 740 mg/d free 4-desmethylsterols, respectively. This intestinal load of 453-740 mg/d of efficacious free plant sterol equivalents had identical effects on lipoproteins.

Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions.
Phytother Res. 2001.
Diet is the first (and sometimes the only) therapeutic approach to hyperlipoproteinaemias. Rice bran oil and its main components (unsaturated fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol) have demonstrated an ability to improve the plasma lipid pattern of rodents, rabbits, non-human primates and humans, reducing total plasma cholesterol and triglyceride concentration and increasing the high density lipoprotein cholesterol level. Other potential properties of rice bran oil and gamma-oryzanol, studied both in vitro and in animal models, include modulation of pituitary secretion, inhibition of gastric acid secretion, antioxidant action and inhibition of platelet aggregation. This paper reviews the available data on the pharmacology and toxicology of rice bran oil and its main components with particular attention to those studies relating to plasma lipid altering effects.

Hair growth
Biol Pharm Bull. 2014. In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment.

Increased immune response in mice consuming rice bran oil.
Eur J Nutr. 2005.
Polyunsaturated fatty acids play a key role in a number of biological functions. Rice bran oil is rich in linoleic acid, an essential n-6 fatty acid. n-6 fatty acids are said to have proinflammatory effects as a result of an increase in n-6 fatty acidderived eicosanoids. Rice bran oil is also rich in gamma-oryzanol, a compound from the unsaponifiable fraction, with antioxidant properties. Our results suggest that although gamma-oryzanol may modulate the immune system, it is not responsible for the overall immunostimulation effect. Rice bran oil -enriched diets could be useful in situations where a potentiation of the immune response was required. The fatty acids composition, more than the unsaponifiable fraction, might be responsible for this effect.

Physical endurance, muscle strength
The effects of gamma-oryzanol supplementation during resistance exercise training.
Int J Sport Nutr. 1997
To determine the effectiveness of gamma-oryzanol supplementation, weight-trained males were randomly divided into supplemented (G-O) and control placebo (Con) groups. The G-O group ingested 500 of gamma-oryzanol according to manufacturer's instructions. Test batteries were administered before (T1), after 4 weeks (T2), and after 9 weeks (T3) of a periodized resistance exercise program. Both groups demonstrated significant increases in 1 repetition maximum muscular strength (bench press and squat) and vertical jump power, with no differences between the groups. No differences between groups were observed for measures of circulating concentrations of hormones (testosterone, cortisol, estradiol, growth hormone, insulin, beta-endorphin), minerals (calcium, magnesium), binding protein (albumin), or blood lipids (total cholesterol, triglycerides, HDL-cholesterol). Resting cardiovascular variables decreased similarly for both groups. These data suggest that 9 weeks of 500 of gamma-oryzanol supplementation does not influence performance or related physiological parameters in moderately weight-trained males.

Indian J Med Res. 2014. Effects of gamma oryzanol supplementation on anthropometric measurements & muscular strength in healthy males following chronic resistance training. Enhanced muscle strength is seen when resistance exercise is combined with the consumption of nutritional supplements. Although there is a limited number of studies available about the efficacy of gamma oryzanol supplementation with resistance exercise in humans, but its usage as a nutritional supplement for strength is common in athletes. The aim of this study was to determine the effects of gamma oryzanol supplementation during 9-week resistance training on muscular strength and anthropometric measurements of young healthy males. Our findings indicated that 600 mg/day gamma oryzanol supplementation during the 9-week resistance training did not change anthropometric and body measurements, but it increased muscular strength in young healthy males. Further, studies need to be done in trained athletes, women, and in patients who suffer from muscular fatigue.

Can I take a gammaoryzanol supplement the same day as serrapeptase or mangosteen?
   You can probably take it with mangosteen, but there is not enough known about serrapeptase to know for sure.

Source Naturals - buy Gamma Oryzanol, 60 mg, 100 Tablets

Supplement Facts:
Calcium 23 mg 2 %
Gamma-oryzanol 60 mg

Buy Gamma Oryzanol

Supplement Facts for Source Naturals Gamma Oryzanol
Serving Size: 1 Tablet
  Amount Per Serving %DV
Calcium 23 mg 2%
gamma-Oryzanol 60 mg
†Daily Value not established

Buy Gamma-Oryzanol pills
Suggested Use: Men - 1 to 3 tablets; Women - 1 or 2 tablets. Take once daily, preferably on an empty stomach (3 or more hours after a meal).