The cause of inflammatory bowel disease IBD is not fully known, but it probably involves an autoimmune disease reaction of the body to its own intestinal tract. Rates of depression, and possibly some types of anxiety disorder, are high among people with inflammatory bowel disease or IBD. Stress can trigger this condition in some patients. People taking the acne drug isotretinoin appear to run an increased risk of developing inflammatory bowel disease. Living in a sunny climate appears to reduce one's risk.
Types of IBD
The 2 major types of inflammatory
bowel disease are
ulcerative colitis and Crohn's disease. As the name
suggests, ulcerative colitis is limited to the colon;
Crohn's disease can
involve any segment of the gastrointestinal tract from the mouth to the
anus.
Natural treatment for Inflammatory Bowel Disease
The nutritional treatment of this condition is underused by many
doctors and we hope that additional research will provide more concrete
answers. Before you make any changes to your prescription medication
treatment, talk to your doctor.
Curcumin has
been found to potentially be of benefit
Curcumin therapy in inflammatory bowel disease: a pilot study.
Dig Disease Sci. 2005.
St. Luke's Roosevelt Hospital Center, Columbia University and Strang Cancer
Center Research Laboratory, New York, New York.
Curcumin, a natural compound used as a food additive, has been shown to have
anti-inflammatory and antioxidant properties in cell culture and animal studies.
A pure curcumin preparation was administered in an open label study to five
patients with ulcerative proctitis and five with Crohn's disease. All proctitis
patients improved, with reductions in concomitant medications in four, and four
of five Crohn's disease patients had lowered CDAI ( Crohn's disease activity
index ) scores and sedimentation rates.
Garlic.
Mol Nutr Food Research. 2014. Orally-administered allyl sulfides from garlic
ameliorate murine colitis. Inflammatory bowel disease (IBD) is an incurable
disease which affects millions of people. Garlic (Allium sativum) preparations
have been traditionally employed for the treatment of diseases affecting the
digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS)
and diallyl disulfide (DADS), two garlic-derived sulfur compounds, on intestinal
inflammation in vivo as well as in intestinal isolated cells.
Aloe Vera
has been tested in ulcerative colitis. See study below.
Polyphenol plant
substances could be helpful
Probiotics have
been shown at times to be helpful when given as a supplement.
Acta Gastroenterol Belg. 2013. The pathophysiology of inflammatory
bowel disease is still incompletely understood. While the development of
the immune system and the establishment of the microflora take place
during infancy young patients often have a more severe and extensive
disease. The differences in composition and concentration of intestinal
microbiota and aberrant immune responses towards the luminal bacteria
prompted the concept of an 'ecological' approach to control the disease
course. Probiotics, living, non pathogenic micro organisms with a
beneficial effect on the host, and prebiotics, oligosaccharides
promoting the growth of the beneficial microflora, have been studied to
this effect. Results have so far been disappointing for Crohn's disease
but encouraging for ulcerative colitis.
Pycnogenol is a
marina pine bark extract
Vitamin D deficiency may be possible
A
vitamin D deficiency can make the condition more severe and
worsen the quality of life for affected individuals.
Vitamin D status in children and young adults with
inflammatory bowel disease.
Pediatrics. 2006. Center for Inflammatory Bowel Disease,
Division of Gastroenterology and Nutrition, Children's Hospital Boston, Boston, MA, USA.
Previous studies of vitamin D status in pediatric patients with inflammatory
bowel disease have revealed conflicting results. We sought to report the
prevalence of vitamin D deficiency (serum 25-hydroxy-vitamin D concentration <
or = 15 ng/mL) in a large population with inflammatory bowel disease, factors predisposing to this problem, and its relationship to bone health
and serum parathyroid hormone concentration. Vitamin D deficiency
is highly prevalent among pediatric patients with inflammatory bowel disease.
Factors predisposing to the problem include having a dark-skin complexion,
winter season, lack of vitamin D supplementation, early stage of disease, more
severe disease, and upper gastrointestinal tract involvement in patients with Crohn's disease. The long-term significance of hypovitaminosis D for this
population is unknown at present and merits additional study.
Polyphenols and
Inflammatory bowel disease
Polyphenols in the treatment of inflammatory bowel disease and
acute pancreatitis: the missing ingredient in enteral and parenteral
nutrition formulas?
Gut. 2006; Tel Aviv Sourasky Medical Center, Israel.
Polyphenols are phytochemicals that are abundant in food and beverages
derived from plants. Although no deficiency- state has been described for
them, increased intake of polyphenols appears to protect against disease
in virtue of their anti-inflammatory and vasculo-protective properties.
This article focuses on four polyphenols with established
anti-inflammatory properties: resveratrol, epigallocatechin gallate,
curcumin and quercetin. In rodents, ingestion or systemic administration
of these agents inhibits Nuclear Factor Kappa B-dependent gene expression
and induces Phase II anti-oxidant and detoxifying proteins. Conditions
prevented and/or ameliorated by these polyphenols include inflammatory
colitis and acute pancreatitis. Enteral nutrition plays an important role
in the management of inflammatory bowel disease - mainly of Crohn's
Disease, and of acute pancreatitis. Parenteral nutrition is reserved for
refractory cases and disease-associated complications. Artificial
nutrition attempts to safely administer the essential and otherwise
beneficial constituents of food to patients with an impaired ability to
ingest or digest food, yet polyphenols are not included in the formulas.
We suggest that the addition of polyphenols to artificial nutritional
formulas would improve the outcome of patients with inflammatory bowel
disease and acute pancreatitis in need of enteral or parenteral nutrition.
A nutritional approach
Ulcerative colitis is a severe
inflammatory bowel disease of the colon that produces bloody diarrhea. Taking a mixture of
several probiotic
bacteria reduces symptoms in patients with ulcerative colitis that doesn't
respond to conventional medications. The probiotic mixture contained four strains of Lactobacillus, three strains of Bifidobacterium
and one strain of Streptococcus salivarius -- all well-known species of
good bacteria. Researchers from the University of Alberta in Edmonton,
Canada enrolled 34 patients with
active ulcerative colitis who were treated with the probiotic mixture twice daily for 6
weeks. A variety of standard treatments had been tried on the patients
first, with no help. Remission occurred in 53 percent of the
patients and an additional 24 percent experienced some degree of
improvement in symptoms. A few patients experienced no improvement or
worsening of their symptoms. The only apparent side effect from the
probiotic mixture was increased bloating. Testing of sampled colonic tissue provided
direct evidence that the probiotic bacteria had, in fact, reached the
diseased sites of the colon. American Journal
of Gastroenterology, 2005.
Diet and food
Eating lots of animal protein appears to increase women's risk of developing IBD.
Dr. Franck Carbonnel of the Centre Hospitalier Universitaire de Bicetre in Paris
followed more than 67,000 women participating in a long-term study of risk
factors for cancer and other common illnesses. The women were 40 to 65 years old
when they enrolled in the study. During follow-up, which averaged about 10
years, women who consumed the most protein were at more than triple the risk of
being diagnosed with IBD; animal protein accounted for most of the risk. Risk
was specifically associated with high intake of meat and fish, but not with
dairy products or eggs. While experts have long suspected that diet might play a
role in inflammatory bowel disease, Dr. Franck Carbonnel says the only links
identified previously were with eating a lot of fats and certain kinds of
sugars. Another recent prospective study found that a diet high in omega-3 fatty
acids decreased inflammatory bowel disease risk, while eating lots of omega-6
fatty acids increased it. Omega-3s are found in fish oil, flax seed oil, and a
few other sources. Meat could contribute to inflammatory bowel disease risk
because digestion of animal protein produces many potentially toxic "end
products," such as hydrogen sulfide and ammonia. A high-protein diet could alter
the mix of bacteria that live in the colon. American Journal of
Gastroenterology, online, 2010.
Reduce your consumption of concentrated milk fats which are used widely in processed and confectionary foods. Concentrated milk fats alter the composition of bacteria in the intestines. These changes can alter the fragile truce between the immune system and the complex but largely beneficial mix of bacteria in the intestines. Harmful bacteria can trigger an unregulated tissue-damaging immune-system response that can be difficult to turn off.
Physical activity, exercise
BMJ. 2013. Physical activity and risk of inflammatory bowel
disease: prospective study from the Nurses' Health Study cohorts. In two large
prospective cohorts of US women, physical activity was inversely associated with
risk of Crohn's disease but not of ulcerative colitis.
Symptom
An inflammatory bowel disease symptom may be mild or severe. The most typical
Inflammatory bowel disease symptom, particularly ulcerative colitis, is bloody diarrhea.
Pain is uncommon but may occur. A common Inflammatory bowel disease symptom is fatigue, which is often related to the inflammation and
anemia that accompany disease activity. Other Inflammatory bowel disease
symptoms that are often reported include fever, loss of appetite, and weight
loss.
The most common Inflammatory bowel disease symptom of Crohn's disease
is
fatigue, followed by abdominal pain and diarrhea.
Because this condition has periods of flare-ups and
remissions, there may be times when there is no Inflammatory bowel disease
symptom. Not uncommonly, patients have been diagnosed with irritable bowel
syndrome before being diagnosed with inflammatory bowel disease.
Women and pregnancy
Women with inflammatory bowel disease have an increased risk of delivering
premature and low-birth-weight infants.
Cause, why it happens
Acute stomach infections may increase the risk of developing inflammatory bowel
disease such as ulcerative colitis or Crohn's disease. A previous episode of
infectious gastroenteritis is associated with a 40 percent greater risk of
inflammatory bowel disease. Gastroenterology, 2008.
Babies treated with antibiotics for middle-ear and other infections may have an increased odds of developing this condition later in childhood. American Journal of Gastroenterology, 2010.
Adults who were physically or sexually abused as children may be at increased risk for the inflammatory bowel disease ulcerative colitis.
Risks of IBD
People with active forms of a group of conditions known as inflammatory bowel
disease, or IBD, seem to be at far greater risk of developing potentially
life-threatening blood clots than previously recognized. The Lancet, February 8,
2010.
In children, pediatric patients
The prevalence of chronic narcotic use among pediatric patients with
inflammatory bowel disease is abnormally high and should be curbed to prevent
further adverse effects from taking hold.
Research study
Lyprinol ( stabilised lipid extract of New Zealand
green-lipped mussel ): a potential preventative treatment modality for
inflammatory bowel disease.
J Gastroenterol. 2005. Child Health Research Institute, Women's and Children's Hospital,
North Adelaide, South Australia, Australia.
Lyprinol (Pharmalink International), the stabilised lipid extract of the New
Zealand green-lipped mussel,
is currently used to relieve symptoms of arthritis. We investigated the effect
of pretreatment with Lyprinol on experimentally induced inflammatory bowel
disease in mice. Conclusions: These findings provide preliminary evidence that
Lyprinol may be potentially useful in ameliorating symptoms of inflammatory
bowel disease. The benefit, however, is unlikely to be due to the omega-3 fatty
acid content. Dose-response evaluation of Lyprinol in experimental inflammatory
bowel disease is warranted.
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate
sodium-induced experimental colitis in mice: attenuation of pro-inflammatory
gene expression.
Biochem Pharmacol. 2005.
Oxidative stress has been shown to play a pivotal role in the onset of
inflammatory bowel disease and carcinogenesis. We evaluated the effects of two
dietary anti-oxidants, rutin and its aglycone quercetin, on dextran sulfate
sodium (DSS)-induced experimental colitis in mice. Female ICR mice were fed a
diet containing 0.1% rutin or 0.1% quercetin for 2 weeks, and given 5% DSS in
drinking water during the second week to induce colitis. Our results
suggest that rutin may be useful for the prevention and treatment of
inflammatory bowel disease and colorectal carcinogenesis via attenuation of
pro-inflammatory cytokine production.
People with inflammatory bowel disease are more likely to have asthma as individuals in the general population. Patients with ulcerative colitis and Crohn's disease, collectively designated inflammatory bowel disease or IBD, were also more likely to have arthritis, bronchitis, or psoriasis than people without IBD
Randomized, double-blind, placebo-controlled
trial of oral aloe vera gel for active ulcerative colitis.
Aliment Pharmacol Ther. 2004.
The herbal preparation, aloe vera, has been claimed to have
anti-inflammatory effects and, despite a lack of evidence of its
therapeutic efficacy, is widely used by patients with inflammatory bowel
disease. AIM: To perform a double-blind, randomized, placebo-controlled
trial of the efficacy and safety of aloe vera gel for the treatment of
mildly to moderately active ulcerative colitis. Forty-four evaluable hospital out-patients were randomly given oral aloe vera gel or
placebo, 100 mL twice daily for 4 weeks, in a 2 : 1 ratio. Oral aloe vera taken for 4 weeks produced
a clinical response more often than placebo; it also reduced the
histological disease activity and appeared to be safe. Further evaluation
of the therapeutic potential of aloe vera gel in inflammatory bowel
disease is needed.
Therapeutic efficacy of pycnogenol in experimental inflammatory bowel
diseases.
Phytother Res. 2004.
Pycnogenol was administered for 10 days by gavage to Sprague-Dawley rats fed
an elemental diet, then inflammatory bowel disease (IBD) was induced by
intrarectal administration of ethanol trinitrobenzene sulfonic acid (TNBS).
Twelve hours after TNBS treatment, the rats were killed, the colon was assessed
by a macroscopic damage score and mucosa homogenate was assayed for
myeloperoxidase (MPO) activity. The supplementation of pycnogenol significantly
inhibited the macroscopic damage score and MPO activity in a dose-dependent
manner. These results suggested that pycnogenol ameliorates TNBS-induced
inflammation by radical scavenging activity, and may have beneficial effects as
a supplement in enteral nutrition for inflammatory bowel diseases.
Lyprinol has been tested in mice.
Questions
Has there been any research done on turmeric
and inflammatory bowel disease? I have been taking about a teaspoon a day
for 3-4 weeks and it
seems to help my colitis symptoms. Of course it is too early to tell if it
is responsible for the decrease in symptoms.
There have been few small studies with curcumin, the extract from
turmeric. More research is needed.