Kidney disease alternative treatment
October 13 2019

The two common causes of chronic kidney disease are diabetes and high blood pressure which are responsible for up to two-thirds of all cases. Diabetes happens when your blood sugar is too high causing damage to many organs in your body, including the kidneys and heart, as well as blood vessels, nerves and eyes. High blood pressure, or hypertension, develops when the pressure of your blood against the walls of your blood vessels increases. In healthy men of normal weight, small increases in weight increase the risk of chronic kidney disease.

Diet, fish and kidney disease
A Western-type diet that's high in red and processed meats, saturated fats and sweets is associated with an increased risk of kidney function decline. Eating fish twice a week may help prevent kidney disease in adults with diabetes. Eating more fruits and vegetables is of great benefit.
   Carbonated beverages, which contain phosphoric acid, have been linked with diabetes, hypertension, and kidney stones, all risk factors for chronic kidney disease.

Kidney disease patients who eat three to four more servings of fruits and vegetables every day could lower their blood pressure and lower their need for medications.

A major role of the kidneys is to maintain phosphorus homeostasis. High serum phosphorus has been linked to all-cause and cardiovascular mortality in chronic kidney disease (CKD) both before and after initiation of renal replacement therapy. Reducing phosphorus intake from foods, especially processed foods, is a good idea.

The types of food that many Southerners seem to prefer -- fried foods, sweet drinks and processed meals -- increased the risk for KD.

A diet high in sodium and potassium can make chronic kidney disease worse.

Supplements helpful for kidney disease, natural products that could help
See the links provided above for diabetes and high blood pressure in order to naturally reduce your blood sugar and blood pressure. Following those suggestions could help improve your kidney function.

Acacia gum may be helpful in chronic kidney disease. So could gum arabic which has been tested in humans.
Alpha lipoic acid helps with blood sugar regulation and is a potent antioxidant, perhaps it can be helpful in limiting damage to the kidneys.
Fish oils could be helpful since they improve microcirculation.

Carnitine supplementation
Saudi J Kidney Dis Transpl. 2017. Carnitine reduced erythropoietin dose required and improved cardiac function of patients on maintenance hemodialysis. Intravenous administration of 2 g carnitine in every hemodialysis (3 times/week), for 8-10 months, reduced doses of darbepoetin alfa required to maintain adequate hemoglobin levels (10-11 g/dL) into 10% of the initial doses. There was also a significant increase in plasma transferrin saturation, increase in left ventricular ejection fraction, and decrease in plasma brain natriuretic peptides.

Carnosine supplementation
Exp Clin Endocrinol Diabetes. 2017. Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the Kidneys of High-Fat Diet / Streptozotocin-Induced Diabetic Rats. Our results indicate that carnosine treatment alleviated renal function and decreased accumulation of oxidation and glycation products in kidneys in high fat diet + STZ-rats.

Flaxseed oil
Iran J Kidney Dis. 2016. Effects of Flaxseed Oil on Serum Lipids and Lipoproteins in Hemodialysis Patients: a Randomized Controlled Trial. Mirfatahi M. Daily consumption of 6 g of flaxseed oil reduces serum triglyceride concentration, which is a risk factor for cardiovascular disease in hemodialysis patients, whereas it has no effects on other lipid parameters, especially lipoprotein(a).

Green tea extract
Recent evidence hints that EGCG is promising therapeutic or protective agent in various kidney diseases.

J Ren Nutr. 2016. Protective Effect of Myo-Inositol Hexaphosphate Phytate on Abdominal Aortic Calcification in Patients With Chronic Kidney Disease. The aim of this study was to evaluate the relationship between physiological levels of myo-inositol hexaphosphate -- phytate -- and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD). Our results suggest that adequate consumption of phytate can prevent AAC in patients with chronic kidney disease. Further prospective studies must be performed to elucidate the benefits of a phytate-rich diet and the associated risk of phosphorus bioavailability in these patients.

Pomegranate intake - Free Radic Biol Med. 2012. One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial. Pomegranate juice intake resulted in a significantly lower incidence rate of the second hospitalization due to infections. Furthermore, 25% of the patients in the pomegranate juice group had improvement and only 5% progression in the atherosclerotic process, while more than 50% of patients in the placebo group showed progression and none showed any improvement.

J Cardiovasc Pharmacol Ther. 2010. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study. This study evaluated the effects of Pycnogenol as an adjunct to angiotensin-converting enzyme (ACE)-inhibitor ramipril treatment of hypertensive patients presenting with early signs of renal function problems. One group of 26 patients was medicated with 10 mg ramipril per day only; a second group of 29 patients took Pycnogenol in addition to the ACE inhibitor over a period of 6 months. At trial end, a lowered systolic and diastolic blood pressure was found in both groups, with a significant further reduction of diastolic pressure in the group given Pycnogenol in addition to ramipril. The protective effects of Pycnogenol for initial kidney damage found in this study warrant further research with a larger number of patients and over a longer period of time.

Resveratrol: Why Is It a Promising Therapy for Chronic Kidney Disease Patients? Oxid Med Cell Longevity. 2013.
Spirulina supplements have been studied in rodents and have provided benefits against gentamicin induced renal toxicity.
Thiamine may be helpful for kidney disease due to type 2 diabetes.

The effects of omega 3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial.
J Hypertension 2009.
Hypertension is a major determinant of progression of chronic kidney disease. Omega-3 fatty acids (omger3FA) protect against CVD via improvements in blood pressure, heart rate, vascular reactivity and serum lipids. Coenzyme Q10 (CoQ) may improve blood pressure and vascular function. This study determined whether omega-3 fatty acids and CoQ have independent or additive effects in improving the cardiovascular profile, particularly blood pressure and heart rate, in nondiabetic patients with CKD stages 3-4. In a double-blind, placebo-controlled intervention, patients were randomized to either omega3 FA (4 g), CoQ (200 mg), both supplements or control (4 g), daily for 8 weeks. Results show that omega-3 fatty acids reduce blood pressure, heart rate and triglycerides in patients with CKD. CoQ had no independent effect on blood pressure but increased heart rate.

I have kidney disease (earlier stage). On a 24 hour urine creatine test my reading was 500 (should be under 150). My last test was over 800 so I am improving. My creatine is in the high range (over 2). I lift weights (powerlifting). Unfortunately taking creatine supplements seems to be out for me because of my naturally high creatine levels. Will those naturally high levels (without creatine supplimentation) still help me gain muscle mass? I also have to watch my protein intake because of my kidney disease. I just started weight lifting a few months ago because my boy has started doing it and it is something we can do together. I am 60 years old and weigh 150 lbs. My legally (raw) performed lifts are 320 Ibs for Deadlift, 200 lbs bench press. This is not much weight in the powerlifting scene, but I noticed that it is not a bad starting point for the "skinny old men division". I have made definite early on gains. I would like to continue this with my boy, however the kidney disease makes it a real challenge even though I am a driven type person. I would appreciate any suggestions on diet or supplements to make gains from my workouts that I can safely incorporate taking my kidney disease into consideration.
   You probably mean creatinine rather than creatine when referring to the urine creatinine test and blood creatinine levels. Unfortunately those with kidney disease are advised to keep their intake of protein and creatine low. Therefore protein or creatine supplements are not advised and they work best for muscle tissue increase. Taking a creatine supplement increases the levels of creatinine in the blood and urine. I have not studied natural ways to increase muscle tissue or strength in those with kidney disease so I don't know which supplements are safe and effective.

What do you recommend for kidney failure? Is there anything that can reverse it? Currently at 15% kidney function. Polycystic Kidney disease was the diagnosis but not confirmed. Only that the kidneys are surrounded with many cysts but a biopsy cannot be accomplished.
   I have not studied the role of nutrition and supplements in the treatment of polycystic kidney disease. Keeping blood pressure under control can slow the effects of polycystic kidney disease.

My mother is 84. A recent routine battery of bloodwork shows that her kidney function is a bit low and her sodium level is low. Her doctor is not concerned about the levels, but she asked me to write and ask if there is a supplement she can take that improve these levels. She is in very good health. She takes 10 mg of Norvasc for blood pressure control, but no other prescription medications.
   Weak kidney function has many causes and it is impossible for me to know the cause, or if in her case it is a normal part of aging, without a full evaluation.

Q. I am a stage 4 kidney patient. While I know CKD (from injury, not insulin) is non-reversible. I have bought a supplement that contains, according to the label, "Raw Kidney Glandular" plus some standard supplements that several kidney health sites endorse. Assuming that this 'glandular' will not regenerate kidney cells, the big question is, "Will it hurt my remaining good cells?
   A. I have no idea what is actually in the product, how it is made, the quality, etc., different companies have different substances within their glandular products so it is difficult to know.

Medications that can cause harm
Use of high potency statins is associated with an increased rate of diagnosis for acute kidney injury in hospital admissions compared with low potency statins. The effect seems to be strongest in the first 120 days after initiation of statin treatment.

People who take popular heartburn pills known as proton pump inhibitors (PPIs) may be more likely to develop chronic kidney disease than individuals who donít use these drugs. The association is worrisome because tens of millions of people a year take these pills, sold by prescription and over-the-counter in some countries, with brand names including Prilosec, Prevacid and Zegerid.

Prescrire Int. 2015. Atypical neuroleptics in elderly patients: acute kidney injury. Using data from health insurance databases, a Canadian team showed that patients aged 65 years or older had a statistically significant increased risk of hospitalisation with acute kidney injury within the 90 days after they were newly prescribed the oral "atypical" neuroleptics risperidone, quetiapine or olanzapine. Adverse effects that can lead to kidney injury were identified: hypotension, acute urinary retention, pneumonia, myocardial infarction and ventricular arrhythmia. All-cause mortality also increased.

The Food and Drug Administration revised warnings on certain medications for type 2 diabetes mellitus based on recent reports of kidney injury. The warning labels on canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR) now include recommendations on ways to minimize the risk and more information on kidney injury.

Air pollution
A study from the University of Michigan found the prevalence of kidney disease was greater in areas of the United States that have worse air quality. American Society of Nephrology, news release, Nov. 15, 2014.

Kidney cancer prevention and natural alternatives

Fiber intake
2013 American Society for Nutrition. Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma in a large US cohort.

Exp Mol Pathol. 2015. Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways.

Maitake mushroom extract
Integr Cancer Ther. 2013. Induction of cell death in renal cell carcinoma with combination of maitake D-fraction and vitamin C.

Meat consumption
Cooking meats at high temperatures, as in barbecuing or pan-frying, increases the risk for kidney cancer.

Tea drinking
Coffee and tea drinkers appear to have a slightly reduced risk. The findings, based on an analysis of 13 previous studies, suggest that coffee and tea may be protective against kidney cancer, while milk, soda and juice seem to have no effect one way or the other. International Journal of Cancer, 2007.

Long-term, regular use of non-aspirin anti-inflammatory painkillers raises the likelihood of developing kidney cancer.

Those who were born at a low weight have an increased risk of eventually developing kidney disease. Perhaps low-birth-weight infants -- those weighing less than 5.5 pounds at birth -- may become susceptible to kidney disease as adults because they have fewer and smaller nephrons. Normally, each kidney has roughly one million nephrons, which are the basic filtering units of the kidneys, extracting waste from the blood and producing urine. American Journal of Kidney Diseases, 2009.