The liver is one of the largest organs in the body -- the skin is
larger -- filling the upper right side of the abdomen inside the rib cage.
It has two parts, a right lobe and a smaller left lobe. The liver has many
important functions, including: Filtering harmful substances from the
blood so they can be passed from the body in stools and urine; making bile
to help digest fats from food; storing
glycogen (sugar), which the body
uses for energy.
There are two ways in which cancer can involve the
liver. The cancer can arise from the liver itself (primary liver cancer)
or it can spread to the liver from a primary tumor at another site
(secondary, or metastatic, cancer).
Natural liver cancer treatment or prevention
Many herbs and nutrients have an influence on liver cancer prevention and
treatment. I will mention a few that I have come across and this article will be updated as more information becomes available. Please note that
research in this area is minimal and should not be used to forego
traditional medical treatment for liver cancer unless your doctor reads
this information and concurs with trying some of these supplements. We
will need significantly more research in this area of herbal medicine
before we can make any statements with confidence regarding the role of
herbs in liver support.
Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma. I3C is available as a dietary supplement.
IP-6 has been reported to have in vivo and in vitro anti- cancer activity.
Broccoli sprouts and their extract could be considered.
Curcumin and turmeric
Naunyn Schmiedebergs Arch Pharmacol. 2018. Synergistic antiproliferative effects
of curcumin and celecoxib in hepatocellular carcinoma HepG2 cells.
Fish oil benefit
Gastroenterology. 2012. Consumption of n-3 fatty acids and fish reduces risk of
hepatocellular carcinoma. Japan Public Health Center-Based Prospective Study
Group. Epidemiology and Prevention Division, Research Center for Cancer
Prevention and Screening, National Cancer Center, Tsukiji, Chuo-ku Tokyo, Japan.
Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as
eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic
acid (DHA). Although consumption of fish and n-3 PUFA has been reported to
protect against the development of some types of cancer, little is known about
its association with hepatocellular carcinoma (HCC). We investigated the
association between fish and n-3 PUFA consumption and HCC incidence in
a population-based prospective cohort study of 90,296 Japanese subjects. We also conducted subanalyses of subjects with known
hepatitis B virus (HBV) or hepatitis C virus (HCV) status, and of subjects who
were anti-HCV and/or hepatitis B surface antigen positive. Among all subjects, consumption of n-3 PUFA-rich fish and individual n-3 PUFAs was associated inversely with HCC, in a
dose-dependent manner. These inverse associations were similar irrespective of
HCV or HBV status. Consumption of n-3 PUFA-rich fish or n-3 PUFAs, particularly
EPA, DPA, and DHA, appears to protect against the development of liver cancer, even among
subjects with HBV and/or HCV infection.
Maitake mushroom
Exp Biol Med (Maywood). 2016. Cold-water extracts of Grifola
frondosa and its purified active fraction inhibit hepatocellular carcinoma in
vitro and in vivo.
Mangosteen is a fruit whose extract has potent substances called xanthones.
Lycium or wolfberry also known as goji berry.
AHCC -- Active Hexose-correlated Compound - is a mushroom extract that has been tested as an immune enhancing, liver protective anti-cancer supplement.
BCAA - Branched chained amino acids.
Cornus officinalis herb
Diet and liver cancer, foods that help
Certain foods, among them milk and fruit, appear to reduce the likelihood of
developing liver cancer. Dr. Renato Talamini, at the National Tumor Institute in
Aviano, and colleagues studied 185 patients with liver cancer and a comparison
group of 412 "controls" without cancer. As intake of various foods went up, the
risk of liver cancer went down. High intakes of milk and yoghurt reduced the
chances of developing liver cancer. High consumption of white meat lowered the
risk by 56 percent, and with high intake of fruit, it went down by 52 percent.
Vegetables, too, apparently had a protective effect, but this didn't reach
significance from a statistical standpoint. The researchers saw that the
findings held good for patients with hepatitis B and hepatitis C virus (HCV)
infection. Dr/. RenatoTalamini advised that, to ward off liver cancer, one
should "adopt a correct diet, rich in fruits and vegetables." Also important, he
added, "is limiting consumption of alcohol beverages and avoiding HCV infection
by practicing safe sex and eliminating needle sharing." International Journal of
Cancer, 2006.
In a population-based prospective study of Japanese individuals, consumption of vegetables, green-yellow and green leafy vegetables was inversely associated with the risk of liver cancer. British Journal Cancer. 2009. Vegetable, fruit and antioxidant nutrient consumption and subsequent risk of hepatocellular carcinoma: a prospective cohort study in Japan.
The amount of fat accumulated around internal abdominal organs influences the likelihood of a recurrence of liver cancer following treatment.
Having a large waistline, a high body mass index (BMI) and type 2 diabetes, raises your risk for liver cancer.
Alcohol use
Drinking more than three drinks a day increases the risk for liver cancer.
In my opinion it is safe for most people to have one drink a day. After all,
many French people drink a little bit of wine daily without major harm to their
health.
Liver cancer symptom
Abdominal pain is generally the initial and most frequent symptom of
liver cancer. While the pain my be severe in some instances, the pain is more
likely to be a persistent dull ache, which intensifies in later stages. Weakness
and weight loss are also common symptoms of liver cancer. Liver cancer is
sometimes called a "silent disease" because in its early stages it often does
not cause symptoms. But, as the tumor grows, liver cancer symptoms may include:
Pain in the upper abdomen on the right side; nausea and vomiting; swollen
abdomen (bloating); weight loss; loss of appetite and feelings of fullness;
fatigue and weakness; yellow skin and eyes, and dark urine from jaundice; and
lastly fever. Please note that a number of medical conditions can cause these
symptoms, they are not exclusive to liver cancer.
Liver cancer treatment
Primary liver cancer is difficult to treat. Surgical removal is the best
option but these tumors are often too large and too extensive for surgery.
Chemotherapy is occasionally used for inoperable tumors but any benefit is
usually short lived. Unfortunately liver cancer cure is difficult.
Several different types of treatment may be offered for
secondary liver cancer, most frequently chemotherapy. Surgeons may also resect
one or two isolated, metastatic liver tumors.
Liver cancer usually does not respond well to conventional
chemotherapy and is often diagnosed too late for surgery to be an option. Many
patients die within a year of diagnosis.
Metastatic liver cancer
Metastatic cancers are tumors that spread from the organ or origin.
Because of its blood supply, the liver is a common site for some cancers to
spread. Some of the most common cancers that spread to the liver are those
originating in the colon, pancreas, lung and breast. Lymphomas and leukemias can
also invade the liver. So can others.
Liver cancer survival rate - liver cancer prognosis
Unfortunately, survival rates for primary liver cancer are low. Survival
rate depends on the stage of the liver cancer. Liver cancer prognosis depends on
many things, including how early the tumor has been detected. Surgery may be an
option if the tumor is small enough and caught early. The success rate of this
surgery, however, is low; only ten to twenty percent of all hepatocellular
carcinoma surgeries succeed in entirely removing cancerous tissue. If the
surgery is not successful, the disease is often fatal within three to six
months; the prognosis for liver metastases is equally poor.
Liver Cancer statistics
Primary liver cancer (cancer that starts in the liver) is one of the most
common cancers in the world, with approximately one million cases reported every
year. This ranges from about 15,000 cases in the United States to more than a
250,000 in China. About 80% of people with primary liver cancer are male.
Liver cancer is diagnosed in about 19,000 Americans
annually but is much more common elsewhere and is the fifth most common cancer
globally. Risk factors include chronic liver infections and some forms of
hepatitis. The disease is common in China and countries without widespread use
of the hepatitis B vaccine, which is routinely given to U.S. infants.
Liver cancer cause
In the western world, most people who develop liver cancer usually also
have a condition called cirrhosis of the liver. This is a fine scarring
throughout the liver which is due to a variety of causes including infection and
heavy alcohol drinking over a long period of time. However, only a small
proportion of people who have cirrhosis of the liver develop primary liver
cancer.
Infection with either the hepatitis B or hepatitis C
virus can lead to liver cancer, and can also be the cause of cirrhosis.
Steroid abuse, smoking, and exposure to toxins are
additional causes of liver cancer.
People who have a rare condition called
haemochromatosis, which causes excess deposits of iron in the body, have a
higher chance of developing liver cancer.
In Africa and Asia a poison called aflatoxin, found in
moldy peanuts and grain, is an important cause of liver cancer.
High blood levels of the
pesticide DDT are
associated with an elevated risk of liver cancer.
Hypothyroidism
Women with long-standing hypothyroidism, commonly referred to as an "underactive
thyroid," are at increased risk of liver cancer. By contrast, hypothyroidism is
not significantly associated with this malignancy in men. Hepatology, May, 2009.
The role of Coffee
It is possible that those who drink coffee could lower their risk.
Liver Cancer Research
Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells:
inhibition of proliferation and induction of apoptosis.
Life Sci. 2005.
Lycium barbarum polysaccharide, extracted from Lycium barbarum that is a kind
of traditional Chinese herb, is found to have anticancer activity. In this
study, the effect of lycium on the proliferation rate, cell cycle distribution
and apoptosis in the human hepatoma QGY7703 cell line were investigated. The
study suggests that the induction of cell cycle arrest and the increase of
intracellular calcium in apoptotic system may participate in the
antiproliferative activity of lycium in human liver cancer QGY7703 cells.
Chemical aspects of
coumarin compounds for the prevention of
hepatocellular carcinomas.
Curr Med Chem Anti-Canc Agents. 2005.
The normalization of plasma alanine aminotransferase (ALT) has been
proved to be a strategy for preventing the development of liver cancer in hepatitis C virus (HCV)-infection. Glycyrrhizin, a
plant medicine, normalizes plasma ALT and prevents liver cancer. However,
glycyrrhizin is administered intravenously and thereby chemical which is
effective on oral administration is required. Coumarin compounds are
active components of herbs used for the treatment of various diseases. The
ability of coumarin compounds to lower plasma ALT were examined. Furocoumarin effectively lowers plasma ALT, but the safety range between
the effective and toxic dosages is narrow. In contrast,
osthole, a simple
coumarin, causes strong reduction of plasma ALT and also inhibits
caspase-3 activation. Furthermore, this chemical is quite safe upon large
dose administration. In the structure of osthole, the methoxy group at
position-7 and the 3-methyl-2-butenyl group at position-8 were elucidated
to be essential for the beneficial effect of this chemical. We conclude
that osthole will become a leading chemical for synthesizing a compound
which prevents liver cancer on oral administration.
Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro.
Am J Chin Med. 2004.
The water extracts of Cornus officinalis Sieb. et Zuce against hepatocellular
carcinoma (HCC) was studied for its chemopreventive potential. Three HCC cell
lines and three leukemic cell lines were tested with XTT assay. Extracts of C. officinalis inhibited all
these HCC cells and leukemic cells at a concentration of 100 microg/ml and was dose-dependent. P53 and Ras significantly
affected its activity against HCC. Extracts of C. officinalis also possessed the
anti-oxidant activity through free radicals scavenging activity at a
concentration of 50 microg/ml. In summary, our experiment implied that C.
officinalis might be a candidate for chemopreventive agent against
hepatocellular carcinoma through the antioxidant and anti-neoplastic effects.
Garcinone E, a xanthone derivative, has potent
cytotoxic effect against hepatocellular carcinoma cell lines.
Planta Med. 2002.
Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has
generally been disappointing and it is most desirable to have more
effective new drugs. We extracted and purified 6 xanthone compounds from
the rinds (peel) of the fruits of Garcinia mangostana L. ( mangosteen ), and then tested the cytotoxic effects of these
compounds on a panel of 14 different human cancer cell lines including 6
hepatoma cell lines. Our results have shown that
one of the xanthone derivatives from mangosteen which could be identified as garcinone E
has potent cytotoxic effect on all HCC cell lines as well as on the other
gastric and lung cancer cell lines included in the screen. We suggest that
garcinone E extract from mangosteen may be potentially useful for the treatment of certain types
of cancer. Liver cancer symptom.
Additional herbs for liver cancer
Celery seed extract
Questions
Would lipoic acid be helpful in liver cancer?
I have not seen any research regarding the use of lipoic acid supplement for liver cancer.
My wife of 61 years of age has been told by the
hospital, after taking some tests such as blood tests and ultrasound, that she
has got liver cancer. It was a big shock for us. She has no symptoms. She takes
yearly abdominal ultrasound and mammogram as well as a chest x-ray and up to
last year these tests were all negative. My wife had breast cancer in 2001 and
she was all right after an operation, chemo, radiotherapy and spent five years
on tamoxefen. She even had liver function tests last August and they were
perfect. Last May’s various blood tests were mainly good except the liver
function tests. The bilirubin was normal, but her ESR was 38. She has an
appetite all right The CBC was good. The doctors want now to give her
chemotherapy. Deep down inside she does not want to have it. She is quite
prepared to try alternative ways. She is very fond of homeopathy. In fact she
goes to one regularly. . Is it possible for Dr. Sahelian to prescribe some
herbs, vitamins, or supplements, to see how she goes for a month and then I take
another ultrasound or blood test for the liver. My wife is light weight ne ver
smoked and does not drink alcohol. She is on a vegetarian diet and takes at
least five servings of fruit a day. I read so much about the goodness of
curcumin, isoflavones, genestein, quercetin, resveratrol and ellagic acid, beta
glucan, etc and of course green tea. Perhaps, such supplements can find a way to
destroy these cancerous cells. On the other hand I would greatly appreciate Dr.
Sahelian’s advice without any liability.
I cannot offer specific advice but hopefully some of the
information on this page will be helpful.