Lupeol cancer benefit and review
January 2 2016

Lupeol type saponin derivatives include lupane, betulinic acid, and betulin.

Where is lupeol found?
Pentacyclic lupane-type triterpenes exemplified by lupeol  are principally found in common fruit plants such as olive, mango fruit, fig, etc.

Lupeol health benefit
Lupeol has many biological activities like anti-inflammatory, anti-arthritic, anti-mutagenic and anti-malarial activity both in in vitro and in vivo systems.

Lupeol for liver cancer
Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells.
Cancer Invest. 2009: Department of Surgery, Lanzhou University Second Hospital, Gansu Province, China.
Here, we investigated its growth-inhibitory effect and associated mechanisms in hepatocellular carcinoma SMMC7721 cells. Lupeol treatment resulted in significant inhibition of cell viability in a dose-dependent manner and caused apoptotic death of this cell line with activation of caspase3 expression. Our results suggested that Lupeol treatment induced growth inhibition and apoptosis in SMMC7721 cells, the mechanism is due to down-regulation of Death receptor 3 expression. We demonstrated that Lupeol appears to be a promising chemopreventive agent for treating hepatocellular carcinoma, and DR3 may be an important target for liver cancer therapy.

Chemical constituents of Periploca forrestii and their cytotoxicity activity.
Zhongguo Zhong Yao Za Zhi. 2009. The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities. Silica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62). Four compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin. Compound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.

Lupeol health benefit and study review

PLoS One. 2013. Lupeol is one of active components in the extract of Chrysanthemum indicum that inhibits LMP1-induced NF-κB activation. We have previously reported that seventy percent ethanol extract of Chrysanthemum indicum Linne (CIE) strongly reduces Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) survival by inhibiting virus-encoded latent infection membrane protein 1 (LMP1)-induced NF-κB activation. To identify an active compound(s) in CIE that inhibits LMP1-induced NF-κB activation, activity-guided fractionation was employed. The CH2Cl2 fraction of CIE strongly reduced LMP1-induced NF-κB activation and LCL viability with relatively low cytotoxic effects on primary human foreskin fibroblast (HFF), HeLa or Burkitt's lymphoma (BL41) cells. Furthermore, lupeol, a pentacyclic triterpene, was identified in the CH2Cl2 fraction of CIE to attenuate LMP1-induced NF-κB activation and LCL viability. This study demonstrates that lupeol is one of active compounds in the CH2Cl2 fraction of CIE that inhibits LMP1-induced NF-κB activation and reduces NF-κB-dependent LCL viability.

Lupeol is a compound in fruits like mangoes, grapes and strawberries, appears to be effective in killing and curbing the spread of cancer cells in the head and neck. An experiment with mice showed lupeol worked most effectively with chemotherapy drugs and had almost no side effects, scientists at the University of Hong Kong said in a report published in the September issue of the journal Cancer Research. "It can suppress the movement of cancer cells and suppress their growth and it is found to be even more effective than conventional drugs (e.g., cisplatin)," said Anthony Yuen, a professor at the University of Hong Kong's surgery department. "It's even more effective if we combine it with chemotherapy drugs, and has very little side effects," he said. The team plans another round of animal test and hopes to proceed eventually to human clinical trials, though it would not commit itself to a timeframe. Head and neck cancers involve cancers of the nose, oral cavity, throat, voice box, thyroid and salivary glands and they more commonly afflict Asians than Westerners. Some of the risk factors include smoking, excessive alcohol consumption, chewing betel nut and diets rich in preserved foods, like salted fish. Such cancers are difficult to treat. Fifty percent of victims are typically diagnosed in advanced stages, when cure rates would be so low they would be considered inoperable. Surgeries on the head and neck are always difficult because they involve the removal of large areas of diseased skin and soft tissues and surgeons need to first figure out how to cover up these open wounds before they can try to excise the tumors. Lupeol - also found in vegetables, olive seed, figs and saw palmetto - appeared to block a natural protein NFkB, which helps cells repair and grow, even cancer cells. In the experiment, lupeol was given to mice infected with malignant head and neck cancer cells. "From the animal models, not only did it suppress the spread, the tumor got smaller. Compared to conventional drugs, lupeol reduced the size of the tumor far faster," said Terence Lee, another member of the research team. Conventional drugs made the mice a lot thinner, but lupeol mice retained their bulk. Emaciation is usually viewed as a bad sign in the fight against cancer.