MAO-B Inhibitor supplements or herbs, natural ways to influence the enzyme
January 9 2016

Brain Res. 2014. Rasagiline prevents neurodegeneration in thiamine deficient rats- a longitudinal MRI study. Neuroprotection is a therapeutic approach for the management of neurodegenerative diseases. Experimental thiamine deficiency (TD) in rats provides a model for selective neurodegeneration accompanied by chronic oxidative deficits. Rats exhibit neurological and cognitive impairments, which can be partially reversed by thiamine administration, enabling the study of mechanisms of neurodegeneration as well as neuroprotection. In this magnetic resonance (MR) study we used various techniques to characterize the neuroprotective effects of rasagiline, a selective MAO-B inhibitor.

Phytother Res. 2014. In Vitro Evaluation of Bacopa monniera Extract and Individual Constituents on Human Recombinant Monoamine Oxidase Enzymes. Considering the nootropic action of B. monniera, we evaluated the effect of clinically available B. monniera extract and six of B. monniera constituents (bacoside A3, bacopaside I, bacopaside II, bacosaponin C, bacosine, and bacoside A mixture) on recombinant human monoamine oxidase (MAO) enzymes. The effect of B. monniera extract and individual constituents on human recombinant MAO-A and MAO-B enzymes was evaluated using MAO-GloTM assay kit (Promega Corporation, USA), following the instruction manual. IC50 and mode of inhibition were measured for MAO enzymes. Bacopaside I and bacoside A mixture inhibited the MAO-A and MAO-B enzymes.

Use with SAM-e antidepressant
I have unfortunately been unable to obtain this information from my doctor or pharmacist because they are unfamiliar with SAM-e, so I am hoping you may be able to help. I am supposed to participate in three native religious ceremonies later this week, which would consist of ingesting a sacred brew containing a vine which has naturally occurring MAOI inhibitors. I unfortunately only just realized today that SAM-e may present a danger in combination with the MAOIs in the brew. I have been taking SAM-e for a few months now for joint issues and mood elevation. I have been somewhat inconsistent in the past month, but have definitely been taking it on a regular basis, ranging from 400-1600mg per day, 5-6 days per week. The last time I took it was this past Saturday. If I cease taking it now, I'm wondering if I would be in any danger of serotonin syndrome if I begin ceremonies on Thursday or Friday night (5-6 days after ceasing SAM-e)?
  A. It's difficult to know for sure but generally a few days of stoppage should be enough to have it out of the body's system.

Hi, I am interested in finding information about herbs that inhibit MAO-B. I understand the herb fo-ti, has ability to inhibit MAO-B, but am concerned about its estrogenic profile. Do you know of any other herbs that inhibit MAO-B.

I was wondering if there are any natural or non prescription MAO-B inhibitors. It is my understanding that deprenyl is reasonably safe with low dosages even though it is a prescription, but I would still prefer something even less harsh that still has an effect if there is anything like that.
    Higher dosages of deprenyl may cause heart rhythm disturbances. Since herbs have a number of active compounds, compared to drugs that have one active substance, it is difficult to find an herb that has a high level of MAO-B inhibition. I am not aware of such yet.

Can I take any natural supplement products as I am taking Nardil? I have read that Inositol can really help with anxiety and depression.
    This is a decision for you and your doctor to make since there are many factors that need to be considered when supplementing with herbs or vitamins besides a medication that a person is taking. As a general rule, it is best to begin any supplement in a very low dosage even if it means taking a portion of a tablet or capsule.

I read on a website that rhodiola herb is described as a MAOI. Is this true?
   We have not seen research in humans that rhodiola herb has this function.

Monoamine oxidases (MAOs) are mitochondrial enzymes, with 2 isoforms, A and B that convert biogenic amines to their corresponding aldehydes via a reaction that produces hydrogen peroxide. Since MAO-A is the predominant form at vascular level we hypothesized that MAO-A-dependent H2O2 production may contribute to the development of endothelial dysfunction and, MAOs inhibition could improve the vascular function, respectively. To this aim aortic rings were isolated from female adult spontaneously hypertensive rats (SHR) and their corresponding (Wistar-Kyoto) controls. The effect of MAO-A inhibitor, clorgyline (10 micromol/l) on endothelium-dependent relaxation (EDR) in response to acetylcholine and endothelium-independent relaxation in response to sodium nitroprusside, was studied in isolated phenylephrine-preconstricted aortic segments in the presence of indometacine.  Inhibition of the MAO-A isoform might be useful in restoring endothelium-dependent relaxation in this experimental model of hypertension in rat.